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Organometallic compounds contain direct bonds between carbon atoms and metal atoms/ions and play roles as homogeneous catalysts and stoichiometric reagents in reactions; available in various chemical compositions, quantities, purities, and reagent grades.
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NVR 3-778 (CAS 1445790-55-5) is a small-molecule modulator targeting the hepatitis B virus (HBV) core protein It is designed to interfere with HBV capsid assembly thereby inhibiting viral genome encapsidation and replication NVR 3-778 exerts its biological activity primarily by disrupting capsid formation and reducing viral replication In in vitro studies NVR 3-778 demonstrates antiviral inhibition with a half-maximal inhibitory concentration (IC50) reported in the low micromolar range Based on these pharmacological properties NVR 3-778 holds research potential in the investigation of HBV biology and the development of alternative therapeutic approaches for chronic hepatitis B infection
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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NVR 3-778 belonging to the SBA (sulfamoylbenzamide) class is a first-in-Class and oral bioavailable HBV CAM (capsid assembly modulator) NVR 3-778 exhibits anti-HBV activity
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
NVR 3-778 (CAS 1445790-55-5) is a small-molecule modulator targeting the hepatitis B virus (HBV) core protein It is designed to interfere with HBV capsid assembly thereby inhibiting viral genome encapsidation and replication NVR 3-778 exerts its biological activity primarily by disrupting capsid formation and reducing viral replication In in vitro studies NVR 3-778 demonstrates antiviral inhibition with a half-maximal inhibitory concentration (IC50) reported in the low micromolar range Based on these pharmacological properties NVR 3-778 holds research potential in the investigation of HBV biology and the development of alternative therapeutic approaches for chronic hepatitis B infection
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PS-1145 (CAS 431898-65-6) is a selective inhibitor of I B kinase (IKK) with an IC50 of 88 nM IKK is a critical component of the upstream NF- B signaling pathway regulating cellular responses to inflammation In vitro studies have demonstrated that PS-1145 blocks TNF -induced NF- B activation in multiple myeloma (MM) cells in a dose- and time-dependent manner increases I B protein levels suppresses IL-6-mediated anti-apoptotic effects and inhibits expression of ICAM-1 Additionally PS-1145 reduces IL-6 secretion from bone marrow stromal cells (BMSCs) and partially limits MM cell proliferation In vivo PS-1145 has been shown to induce apoptosis in DMBA-induced skin tumors in rats by inhibiting NF- B and VEGF activity The compound remains in the preclinical research stage
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Trimethyl[3-(trimethoxysilyl)propyl]ammonium (chloride) (50% in methanol) is a biochemical reagent. It can be used as a biological material or organic compound for various life science related research applications. This product is for research use only.
Used as a biochemical reagent
Applicable as a biological material
Applicable as an organic compound
Suitable for life science research
Appearance as a liquid
Color from colorless to light yellow
Store as a solution at -20°C
Protect from light
Stable for 2 years when stored correctly
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3-(2-iodoethoxy)prop-1-yne is an alkyne-containing crosslinker used for copper-catalyzed azide-alkyne click chemistry and synthetic conjugation. The iodoether group serves as an effective leaving group for nucleophilic substitution, enabling downstream modification and bioconjugation in organic synthesis workflows.
Reactive terminal alkyne for efficient click chemistry conjugation.
Iodoether leaving group enables nucleophilic substitution.
Liquid physical state for easy handling and accurate dosing.
Suitable for bioconjugation and small-molecule synthesis applications.
Store protected from light at 4°C; in solvent, store at -80°C for long-term stability.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More