Solvents
Medchemexpress LLC D-Fructose-4-13C | 84270-09-7 | 5 MG
D-Fructose-4-13C is the 13C labeled D-Fructose, a naturally occurring monosaccharide found in many plants.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Cambridge Isotope Laboratories WHO Coplanar Mono-Ortho PCB PCB-170 PCB-180 (13C12 99%) 200 ng/mL in nonane 1 2 mL
WHO Coplanar Mono-Ortho PCB PCB-170 PCB-180 (13C12 99%) 200 ng/mL in nonane 1 2 mL
Apexbio Technology LLC TWS119 601514-19-6 10mM (in 1mL DMSO)
TWS119 (CAS 601514-19-6) is a selective inhibitor of glycogen synthase kinase-3 (GSK-3 ) exhibiting an IC50 of approximately 30 nM Originally identified from a library of pyrrolopyrimidine-based compounds TWS119 binds GSK-3 with a Kd value around 126 nM By inhibiting GSK-3 activity TWS119 modulates downstream transcriptional events promoting neuronal differentiation in murine embryonic carcinoma (P19) and mouse embryonic stem cells through mechanisms distinct from classical Wnt signaling Due to this property TWS119 serves as a useful tool for research in neural differentiation and regenerative medicine
Apexbio Technology LLC AM1241(Synonyms: AM-1241, CB2 receptor agonist AM1241, Cannabinoid receptor CB2 agonist AM1241, AM 1241), 10mM (in 1mL DMSO), CAS: 444912-48-5.
AM1241 (CAS number 444912-48-5) is a selective agonist of the cannabinoid receptor type 2 (CB2) a G protein-coupled receptor encoded by the CNR2 gene CB2 receptors modulate inflammation and neuropathic pain pathways outside the central nervous system In vitro studies suggest stereoisomer-dependent activities specifically the S-enantiomer demonstrates higher functional potency toward human and rodent CB2 receptors compared to the R-enantiomer In animal models AM1241 administration reduces neuropathic pain phenotypes including hyperalgesia and allodynia and shows potential for delaying disease progression in an ALS (amyotrophic lateral sclerosis) mouse model Currently AM1241 remains a valuable investigational tool in preclinical pain and neurodegeneration research
Apexbio Technology LLC PF-477736 952021-60-2 10mM (in 1mL DMSO)
PF-477736 is an ATP-competitive small-molecule inhibitor of checkpoint kinase 1 (Chk1) It selectively inhibits Chk1 kinase activity demonstrating nanomolar inhibitory potency in kinase assays and exhibits lower affinity toward related kinases such as CDK1 and Chk2 In vitro studies utilizing human cancer cell lines show PF-477736 disrupts Chk1-dependent G2-phase cell-cycle arrest induced by DNA-damaging agents preferentially targeting tumor cells with compromised p53 function while minimizing cytotoxicity to normal cells PF-477736 is widely utilized experimentally to study DNA damage response mechanisms potential chemosensitizing effects and therapeutic implications for cancers harboring p53 mutations
Apexbio Technology LLC K02288 1431985-92-0 10mM (in 1mL DMSO)
K02288 (CAS 1431985-92-0) is a highly selective small molecule inhibitor targeting activin receptor-like kinase 2 (ALK2) a type I receptor involved in BMP signaling Structurally classified as a 2-aminopyridine derivative K02288 demonstrates strong potency against ALK2 (IC50 1 1 nM) It exhibits selectivity across the ALK receptor family showing lower activity on ALK3 ALK6 and minimal inhibition against ALK4-5 In cell-based assays using C2C12 cells treated with BMP ligands K02288 dose-dependently reduces Smad phosphorylation It has utility in research elucidating ALK2-mediated signaling pathways and developmental processes exemplified by inducing dorsalized phenotypes in zebrafish embryos
Apexbio Technology LLC BV6 1001600-56-1 10mM (in 1mL DMSO)
BV6 (CAS 1001600-56-1) is a selective inhibitor targeting the inhibitor of apoptosis protein (IAP) family The IAP family includes proteins such as XIAP c-IAP1 and c-IAP2 that regulate programmed cell death pathways BV6 induces apoptosis and sensitizes cancer cells to chemotherapeutic agents and radiation by decreasing expression levels of IAPs including XIAP and c-IAP1 In vitro treatment with BV6 exhibited an IC50 of 7 2 M in H460 non-small cell lung carcinoma cells and enhanced their response to radiation BV6 is employed in research exploring cancer cell apoptosis modulation and therapeutic resistance
Apexbio Technology LLC Fludarabine(Synonyms: Fludarabine Phosphate, Fludara, Fludarabinum, 2-Fluoro-ara-AMP, 9H-Purin-6-amine), 10mM (in 1mL DMSO), CAS: 21679-14-1.
Fludarabine (CAS 21679-14-1) is a purine analog prodrug that inhibits DNA synthesis Upon cellular uptake it undergoes phosphorylation to its active triphosphate form (F-ara-ATP) disrupting DNA replication through inhibition of critical enzymes such as DNA primase DNA ligase I ribonucleotide reductase and DNA polymerases and In human myeloma RPMI8226 cell assays fludarabine suppressed cell growth reduced Akt phosphorylation and lowered anti-apoptotic proteins XIAP and Survivin In vivo studies demonstrated marked tumor growth inhibition in RPMI8226 xenograft models Fludarabine serves as a tool in oncology research particularly leukemia and multiple myeloma-related studies
Cell Signaling Technology DMSO (Dimethyl Sulfoxide), Sterile 10 ml
DMSO (Dimethyl Sulfoxide), Sterile 10 ml
Apexbio Technology LLC STF-62247 315702-99-9 10mM (in 1mL DMSO)
STF-62247 (CAS 315702-99-9) is a small molecule that selectively targets renal cell carcinoma (RCC) cells carrying von Hippel-Lindau (VHL) gene deletions It exhibits cytotoxicity in both wild-type and VHL-deficient RCC cells via a mechanism independent of hypoxia-inducible factor (HIF) with reported IC50 values of 16 M and 0 625 M respectively In VHL-deficient RCC cells STF-62247 induces acidification autophagy and subsequent apoptotic cell death In mouse xenograft models bearing VHL-deficient SN12C tumors STF-62247 significantly reduced tumor growth This compound is useful for studying therapeutic strategies targeting VHL-deficient tumors
Apexbio Technology LLC Salubrinal 405060-95-9 10mM (in 1mL DMSO)
Salubrinal is a cell-permeable inhibitor of eukaryotic translation initiation factor 2 alpha (eIF2 ) dephosphorylation exhibiting an IC50 of approximately 15 M It prevents phosphatase complexes from removing phosphate groups from eIF2 thus maintaining its phosphorylated state and modulating protein synthesis during cellular stress responses Salubrinal is utilized experimentally in vitro to investigate apoptotic mechanisms related to endoplasmic reticulum (ER) stress For instance it provides cytoprotection against ER stress-induced apoptosis triggered by protein glycosylation inhibitors or ER-Golgi trafficking inhibitors In vivo murine models employ salubrinal to explore cellular processes underlying oxidative stress and nephrotoxicity induced by chemotherapeutic treatments through modulation of ER stress-associated apoptosis signaling pathways Currently no clinical trials involving salubrinal have been reported
Apexbio Technology LLC JNJ-26481585 875320-29-9 10mM (in 1mL DMSO)
JNJ-26481585 (CAS 875320-29-9) is a small-molecule inhibitor targeting class I histone deacetylases (HDACs) specifically HDAC1 HDAC2 and HDAC3 with reported IC50 values of 0 11 0 33 and 4 8 nM respectively It exhibits potent anti-proliferative activity across various human cancer cell lines including lung breast colon prostate ovarian and brain cancers (IC50 range 3 1 246 nM) Mechanistically JNJ-26481585 induces histone H3 acetylation alleviates HDAC-mediated repression of the p21waf1 cip1 promoter and promotes apoptosis in colorectal cancer cell models Consequently this compound serves as a research tool for cancer epigenetics and therapeutic assessment
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide, 67-68-5, MFCD00002089, 100mL
Linear Formula (CH3)2SO, ≥99.5% (GC), Molecular Weight 78.13, plant cell culture tested, Synonym: DMSO
Apexbio Technology LLC Alendronate sodium(Synonyms: Alendronate sodium hydrate, Sodium alendronate, Alendronic acid monosodium salt, Fosamax), 10mM (in 1mL DMSO), CAS: 129318-43-0.
Alendronate sodium (CAS 129318-43-0) is a small molecule inhibitor of osteoclast-driven bone resorption It acts by selectively inhibiting farnesyl diphosphate synthase (FPPS) an essential enzyme within the mevalonate (HMG-CoA reductase) pathway exhibiting an IC50 of approximately 460 nM against recombinant human FPPS Inhibition of FPPS prevents protein prenylation and sterol biosynthesis within osteoclasts subsequently inducing apoptosis in macrophage-lineage cells Alendronate sodium is commonly utilized in biomedical research focused on bone metabolism disorders osteoclast biology and evaluation of therapeutic strategies targeting bone density loss
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide anhydro1L
Dimethyl Sulfoxide is an apolar protic solvent that is generally used as a reaction medium and reagent in organic reactions.