Aminosaccharides
Medchemexpress LLC 2-azidoethyl β-D-lactoside | 230286-11-0 | MFCD19981033 | 95.0% | 411.36 g/mol | C14H25N3O11 | 10 MG
2-Azidoethyl β-D-lactoside is an azide-functionalized β-D-lactoside reagent designed for click-chemistry conjugation. It reacts with alkyne-containing molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC), enabling efficient bioconjugation in glycochemistry and chemical biology workflows.
BIOHIPPO O-GlcNAc Rabbit mAb
U-Blot Pan-O-GlcNAc Rabbit mAb (Monoclonal) is a Rabbit-derived monoclonal antibody that specifically recognizes O-GlcNAc a o-glcnacylation modification at Ser(S)/Thr(T) O-GlcNAc (short for O-linked -N-acetylglucosamine) is a reversible enzymatic post-translational modification found on serine and threonine residues of nucleocytoplasmic proteins The modification is characterized by a -glycosidic bond between the hydroxyl group of serine or threonine side chains and N-acetylglucosamine (GlcNAc) It is widely involved in the regulation of diverse cellular processes including transcription cell cycle signal transduction and stress response Dysregulation of O-GlcNAcylation has been closely linked to cancer neurodegeneration diabetes and inflammatory diseases Notably elevated O-GlcNAc levels in many cancers have been reported to suppress apoptosis by inhibiting caspase activation Supplied as 100 uL
Medchemexpress LLC D(+)-Galactosamine hydrochloride | 1772-03-8 | 99.9% | 215.63 | 25 MG
D(+)-Galactosamine hydrochloride is an established experimental toxin that primarily causes liver injury through the generation of free radicals and depletion of UTP nucleotides. Intoxication with D(+)-Galactosamine hydrochloride also induces renal dysfunction, with renal failure often associated with the end-stage of liver damage. The combination of Lipopolysaccharide/D(+)-Galactosamine is a known animal model for inducing acute liver injury, leading to fulminant hepatic failure.
- Causes liver injury through generation of free radicals.
- Leads to depletion of UTP nucleotides.
- Induces renal dysfunction.
- Useful in animal models for acute liver injury.
Medchemexpress LLC O-Linked GlcNAc transferase substrate | 954381-93-2 | 98.25% | 1783.08 | 10 MG
O-Linked GlcNAc transferase substrate is a biologically active peptide that functions as a substrate for O-linked GlcNAc transferase (OGT), a eukaryotic glycosyltransferase that utilizes UDP-GlcNAc as a glycosyl donor.
- Biological active peptide
- Substrate of O-linked GlcNAc transferase (OGT)
- White to off-white solid appearance
- High purity of 98.25%
- Soluble in DMSO and H2O at 100 mg/mL
- Sequence: Lys-Lys-Lys-Tyr-Pro-Gly-Gly-Ser-Thr-Pro-Val-Ser-Ser-Ala-Asn-Met-Met
Medchemexpress LLC D(+)-Galactosamine hydrochloride | 1772-03-8 | 99.9% | 215.63 | 1 G
D(+)-Galactosamine hydrochloride is an established experimental toxin known to primarily cause liver injury by generating free radicals and depleting UTP nucleotides. It also induces renal dysfunction, often leading to renal failure associated with end-stage liver damage. This compound can be used to induce hepatitis models, mimicking viral hepatitis by causing lipid peroxidation and cell membrane deterioration.
- Induces apoptosis and necrosis in primary cultures of rat hepatocytes.
- Causes caspase-3 activation and DNA fragmentation.
- Used as an animal model for fulminant hepatic failure.
- Induces acute liver failure in mice when co-administered with Lipopolysaccharide.
Medchemexpress LLC D(+)-Galactosamine (hydrochloride) | 1772-03-8 | 99.9% | 215.63 | 200 MG
D(+)-Galactosamine hydrochloride is an established experimental toxin that primarily causes liver injury by generating free radicals and depleting UTP nucleotides. It also induces renal dysfunction, with renal failure often associated with the end-stage of liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure.
- Induces apoptosis and necrosis in primary cultures of rat hepatocytes.
- Induces caspase-3 activation and DNA fragmentation.
- Used to induce hepatitis models similar to viral hepatitis.
- Induces lipid peroxidation and deterioration of cell membranes.
- Can be used in rat models (Wistar) to study liver damage.
- Can be used in mouse models (C57BL/6J) for acute liver failure induction.
Medchemexpress LLC D(+)-Galactosamine hydrochloride | 1772-03-8 | 99.9% | 215.63 | 500 MG
D(+)-Galactosamine hydrochloride is an established experimental toxin that primarily causes liver injury by generating free radicals and depleting UTP nucleotides. It also induces renal dysfunction, with renal failure often associated with the end-stage of liver damage. Lipopolysaccharide/D(+)-Galactosamine-induced acute liver injury is a known animal model of fulminant hepatic failure.
- Induces apoptosis and necrosis in primary rat hepatocyte cultures.
- Causes caspase-3 activation and DNA fragmentation.
- Induces hepatotoxicity similar to viral hepatitis.
- Suitable for research use only.
Medchemexpress LLC HY-B1125 100mg Medchemexpress, Glucosamine CAS:3416-24-8 Purity:>98%
Medchemexpress, HY-B1125 100mg Glucosamine CAS:3416-24-8 Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical UDP-GalNAcsodIum salt 1mg
A nucleotide sugar; used by glycosyltransferases to glycosylate various substrates
Medchemexpress LLC 4-(2-azidoethyl)phenol | 74447-34-0 | MFCD24452536 | 99.8% | 163.18 g/mol | C8H9N3O | 10 MG
4-(2-Azidoethyl)phenol is an azide-containing phenol reagent used as a clickable probe for APEX2-mediated proximity labeling and downstream biotinylation. It supports reliable protein labeling for proteomic workflows and can be processed via multiple biotinylation strategies for analysis.
- Clickable APEX2 probe for proximity labeling.
- Enables two biotinylation routes for downstream analysis.
- High purity suitable for biochemical and proteomic assays.
- Available in multiple small pack sizes for experimental flexibility.
- Stable when stored under recommended conditions.
Medchemexpress LLC Azidoethyl-SS-PEG2-Boc | 2144777-83-1 | 351.49 | 1 G
Azidoethyl-SS-PEG2-Boc is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Azide group. This allows it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules containing Alkyne groups, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- Peg-based PROTAC linker
- Click chemistry reagent
- Contains an Azide group for CuAAc and SPAAC reactions
- For research use only
Medchemexpress LLC Azidoethyl-SS-PEG2-Boc | 2144777-83-1 | 351.49 | 250 MG
Azidoethyl-SS-PEG2-Boc is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Azide group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing Alkyne groups. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules possessing DBCO or BCN groups.
- Utilized in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
- PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins