Glycosyl compounds
Selleck Chemical LLC D 4476
D 4476 is a potent selective and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1 respectively Also acts as an ALK5 inhibitor with IC50 of 500 nM
Apexbio Technology LLC ISRIB (trans-isomer) 1597403-47-8 10mM (in 1mL DMSO)
ISRIB (trans-isomer) (CAS 1597403-47-8) is a small molecule inhibitor of the integrated stress response (ISR) ISR activation involves the phosphorylation of eukaryotic initiation factor 2 (eIF2 ) by stress-sensitive kinases leading to reduced global protein synthesis and enhanced translation of select mRNAs ISRIB counteracts ISR signaling by reversing the translational suppression induced by phosphorylated eIF2 inhibiting production of ATF4 protein decreasing stress granule assembly and promoting polyribosome formation during endoplasmic reticulum (ER) stress ISRIB stabilizes and activates eIF2B by facilitating its dimerization Rodent studies demonstrate ISRIB s capacity to enhance hippocampal-dependent spatial and fear-related learning and memory highlighting its utility in neuroscience research
Apexbio Technology LLC Amygdalin 29883-15-6 10mM (in 1mL DMSO)
Amygdalin is a cyanogenic glycoside naturally obtained from bitter almond seeds (semen armeniacae amarae) Chemically it consists of two sugar molecules (glucose) benzaldehyde and a nitrile group forming a stable glycosidic compound that releases hydrogen cyanide (HCN) upon enzymatic hydrolysis The compound s biological action is mediated through enzymatic cleavage by cellular -glucosidase primarily resulting in cyanide liberation and subsequent cytotoxicity In biomedical research amygdalin is extensively applied in studies focused on tumor cell viability apoptosis induction mechanisms and cyanide toxicity effects in various cellular and animal models Additionally it serves as an experimental substrate for enzyme kinetics studies investigating -glucosidase or glycoside hydrolase activity and as a reference compound in analytical assay development within biochemical and toxicological methodologies
Apexbio Technology LLC 3-DEAZAADENOSINE 5MG
3-Deazaadenosine (CAS 6736-58-9) is an inhibitor of S-adenosylhomocysteine (SAH) hydrolase an enzyme responsible for the reversible hydrolysis of SAH into adenosine and homocysteine Inhibition of SAH hydrolase by 3-Deazaadenosine (Ki 3 9 M) elevates intracellular SAH concentrations altering the SAH-to-SAM (S-adenosylmethionine) ratio and consequently suppressing SAM-dependent methyltransferase activities In vitro studies demonstrate its antiviral activity against Ebola and Marburg viruses in various primate and mouse cell lines Animal studies indicate protective efficacy against lethal Ebola infection in BALB/c mice Currently 3-Deazaadenosine remains in preclinical research
Apexbio Technology LLC CYANIDIN-3-O-GLUCOSIDE CL 20MG
Cyanidin-3-O-glucoside chloride (CAS 7084-24-4) is an anthocyanin compound isolated from the pericarp of Glycine max (L ) Merr Structurally it belongs to flavonoid derivatives exhibiting antioxidative and anti-inflammatory properties through modulation of cellular signaling pathways such as NF- B and MAPK Research demonstrates its bioactivity in vitro and in vivo including the attenuation of oxidative stress suppression of inflammatory cytokines and beneficial effects on metabolic regulation It is utilized extensively in biomedical research to investigate oxidative and inflammatory mechanisms underlying chronic diseases Store in tightly sealed cool and dry conditions to maintain stability
Sigma Organic Chemistry Sucrose benzoate | 500G | 12738-64-6 | MFCD00047542
Sucrose benzoate, 500G
About This Item:
Storage: room temp
EINECS Number: 235-795-5
Sigma Organic Chemistry (R)-alpha-Acryloyloxy-beta,beta-dimethyl-gamma-butyrolactone | 5G | 102096-60-6 | MFCD00043403 | 0.95
(R)-alpha-Acryloyloxy-beta,beta-dimethyl-gamma-butyrolactone | 5G | 102096-60-6 | MFCD00043403 | 0.95
Selleck Chemical LLC D 4476
D 4476 is a potent selective and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1 respectively Also acts as an ALK5 inhibitor with IC50 of 500 nM
Selleck Chemical LLC Licochalcone D
Licochalcone D (Lico D LCD LD) a flavonoid isolated from a Chinese medicinal plant Glycyrrhiza inflata has antioxidant anti-inflammatory and anti-cancer properties Licochalcone D inhibit phosphorylation of NF- B p65 in LPS signaling pathway Licochalcone D inhibits JAK2 EGFR and Met (c-Met) activities and induces ROS-dependent apoptosis Licochalcone D also induces caspases activation and poly (ADP-ribose) polymerase (PARP) cleavage
Selleck Chemical LLC IPTG
IPTG (Isopropyl -D-thiogalactoside Isopropyl thiogalactoside Isopropyl -D-1-thiogalactopyranoside lad-y) is a galactose and a molecular mimic of allolactose that triggers transcription of the lac operon stimulating protein expression
