Glycosyl compounds
Medchemexpress LLC Galactose 1-phosphate-13C potassium | 478518-78-4 | 98.8% | 337.31 | 10 MG
Galactose 1-phosphate-13C (potassium) is the 13C labeled Galactose 1-phosphate Potassium salt, an intermediate in galactose metabolism and nucleotide sugar. It is intended for research use only.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes have been incorporated into drug molecules as tracers for quantitation.
- Deuteration can affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC D-(-)-Pantolactone | 599-04-2 | 99.96% | 130.14 | 100 G
D-(-)-Pantolactone is an important intermediate used in the synthesis of other active compounds, such as the molluscicide Cyanolide A. It also functions as a calibrant for circular dichroism (CD). Derivatives of D-(-)-Pantolactone have shown good inhibitory activities against FAS and lipid accumulation, making them useful in the research of anti-obesity drugs.
- High purity: 99.96%
- White to off-white solid appearance
- Store powder at -20°C for 3 years, 4°C for 2 years
- Store in solvent at -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO (100 mg/mL)
Medchemexpress LLC D-64131 | 74588-78-6 | C16H13NO2 | 5 MG
D-64131 is an orally active tubulin inhibitor with an IC50 of 0.53 μM for tubulin polymerization. It has antimitotic activity and can be used for cancer research. It is antimitotic by binding to β-tubulin, which destabilizes microtubules and arrests mitotic cells in the M-phase. It inhibits the proliferation of tumor cells from 12 of 14 different organs and tissues with mean IC50s of 62 nM. It is also cytotoxic towards MDR/MRP tumor cell lines. In vivo studies have shown that D-64131 significantly inhibits tumor growth in human amelanoic melanoma MEXF 989 tumor xenograft mice models and exhibits oral bioavailability, being well tolerated at efficacious doses.
- Orally active tubulin inhibitor
- Potent antimitotic activity
- Broad-spectrum anti-tumor activity
- Cytotoxic to drug-resistant cell lines
- Well-tolerated in vivo
- Research use only
- High purity
Medchemexpress LLC α-Lactose | 14641-93-1 | 1 ML
α-Lactose is the major sugar found in milk, existing in two anomeric forms, α and β. The α form typically crystallizes as a monohydrate. As an essential sugar abundant in human and animal milk, it serves as a basic nutrient and a primary substrate for fermentative processes in dairy products like yogurt and kefir. This product is provided with a purity of 98.0% and has a molecular weight of 342.30.
- Major sugar found in milk
- Essential nutrient
- Primary substrate for fermentative processes in dairy products
- Exists in two anomeric forms (α and β)
- α form typically crystallizes as a monohydrate
- Purity: 98.0%
- Molecular weight: 342.30
Medchemexpress LLC [D-Trp34]-Neuropeptide Y | 153549-84-9 | 99.7% | 4311.72 | 5 MG
[D-Trp34]-Neuropeptide Y is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist, showing significantly less potency at NPY Y1, Y2, Y4, and y6 receptors. This compound is known to markedly increase food intake in rats.
- Potent and selective NPY Y5 receptor agonist
- Significantly less potent at NPY Y1, Y2, Y4, and y6 receptors
- Increases food intake in rats
- Soluble in water at 100 mg/mL (23.19 mM)
- Appears as a white to off-white solid
Medchemexpress LLC Capsaicin β-D-glucopyranoside | 153409-16-6 | 90.55% | 467.55 | 10 MG
Capsaicin β-D-glucopyranoside is a glucoside converted by Capsaicin. Capsaicin is the active ingredient of chili peppers and gives them the characteristic pungent flavor.
- Solid appearance
- White to off-white color
- Molecular formula: C24H37NO8
- Derived from plants, solanaceae, capsicum annuum L.
- Storage as solid at -20°C, sealed, away from moisture and light
- Storage in solvent at -80°C for 6 months or -20°C for 1 month, sealed, away from moisture and light
- Soluble in DMSO at 100 mg/mL
Medchemexpress LLC Sapintoxin D | 80998-07-8 | 99.9% | 1 MG
Sapintoxin D is a fluorescent phorbol ester used for studying the activation of protein kinase C (PKC). It acts as a calcium-dependent PKC activator and exhibits antiviral activity against HIV2 ROD, HIV1 3B in MT4 cells, and chikungunya virus in Vero cells. Its molecular weight is 539.62, and its formula is C30H37NO8. It appears as a white to off-white solid and is derived from Plants Euphorbiaceae Shirakiopsis indica (Willd.) Esser. It is intended for research use only.
- Fluorescent phorbol ester
- Utilized for studying the activation of protein kinase C (PKC)
- Calcium-dependent PKC activator
- Demonstrated antiviral activity against HIV2 ROD and HIV1 3B in MT4 cells
- Demonstrated antiviral activity against chikungunya virus in Vero cells
- White to off-white solid appearance
- Derived from Plants Euphorbiaceae Shirakiopsis indica
- For research use only
Medchemexpress LLC Alpha Sarcoglycan Antibody (YA2068) | 10 UL
The alpha Sarcoglycan Antibody (YA2068) is a Rabbit-derived, non-conjugated IgG monoclonal antibody designed to target alpha Sarcoglycan. Alpha Sarcoglycan is a component of the sarcoglycan complex, which forms a structural link between the F-actin cytoskeleton and the extracellular matrix.
- Applications include WB, IHC-P, and IP
- Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
- Store at -20°C for 1 year
- Avoid repeated freeze/thaw cycles
- Liquid appearance
- Rabbit host
- Reactivity with human, mouse, and rat samples
- Non-conjugated
- Affinity purified
Medchemexpress LLC Fluorescein Di-β-D-Glucuronide | 134869-04-8 | HY-D1460 | 96.6% | 684.55 | 5 MG
Fluorescein Di-β-D-Glucuronide is a fluorescent probe used for non-invasive imaging of intestinal bacterial β-glucuronidase activity in nude mice. It reveals the in vitro and in vivo activity of intestinal bacterial β-glucuronidase, facilitating pharmacodynamic studies of specific bacterial β-glucuronidase inhibitors in animal studies.
- Fluorescent probe
- Utilized for non-invasive imaging of intestinal bacterial β-glucuronidase activity
- Reveals in vitro and in vivo activity of intestinal bacterial β-glucuronidase
- Facilitates pharmacodynamic studies of specific bacterial β-glucuronidase inhibitors
- Classified as Fluorescent Dye, Enzyme Labeling, Protease Substrate
- Relevant to Disease Areas: Infection, β-glucuronidase, Bacterial
Medchemexpress LLC Galactose 1-phosphate Potassium salt | 19046-60-7 | 99.0% | 336.32 | 25 MG
Galactose 1-phosphate Potassium salt is an intermediate involved in galactose metabolism and nucleotide sugars. It acts as an inhibitor for several enzymatic activities, including phosphoglucomutase, glucose-6-phosphate phosphatase, glucose-6-phosphate dehydrogenase, glycogen phosphorylase, UDP-glucose pyrophosphorylase, and inositol monophosphatase. It is intended for research use only.
- Intermediate in galactose metabolism and nucleotide sugars.
- Inhibitor of various enzymatic activities (phosphoglucomutase, glucose-6-phosphate phosphatase, glucose-6-phosphate dehydrogenase, glycogen phosphorylase, UDP-glucose pyrophosphorylase, and inositol monophosphatase).
- Available in solid and solution forms.
- High purity (99.0%).
Medchemexpress LLC Prostaglandin D Synthase Antibody (YA1739) | 100 UL
Prostaglandin D Synthase Antibody (YA1739) is a rabbit-derived, non-conjugated IgG monoclonal antibody that targets Prostaglandin D Synthase. This protein acts as a glutathione-independent prostaglandin D synthase, converting prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2). PGD2 plays various roles as a neuromodulator, a trophic factor in the central nervous system, and is involved in smooth muscle contraction/relaxation, as well as being a potent inhibitor of platelet aggregation. The related gene is primarily expressed in the brain, with studies suggesting its involvement in regulating non-rapid eye movement sleep.
- Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
- Stored at -20°C for 1 year, avoid repeated freeze/thaw cycles
- Liquid appearance
- Reactivity with human, mouse, and rat
- Applications: WB, IHC-P, IHC-F, ICC/IF
Medchemexpress LLC D-α-Hydroxyglutaric acid | 13095-47-1 | 98.0% | 148.11 | 1 ML
D-α-Hydroxyglutaric acid is the primary metabolite that accumulates in the neurometabolic disorder D-2-hydroxyglutaric aciduria. It acts as a weak competitive antagonist of α-ketoglutarate (α-KG), inhibiting multiple α-KG-dependent dioxygenases with a Ki of 10.87 mM. This compound increases reactive oxygen species (ROS) production, binds to and inhibits ATP synthase, and suppresses mTOR signaling. It also accumulates in human cancers with neomorphic mutations in IDH1 and IDH2 genes.
- Weak competitive antagonist of α-ketoglutarate (α-KG).
- Inhibits multiple α-KG-dependent dioxygenases.
- Increases reactive oxygen species (ROS) production.
- Binds to and inhibits ATP synthase.
- Suppresses mTOR signaling.
- Accumulates in human cancers with IDH1 and IDH2 gene mutations.
![Alkali Scientific Tris Base Ultra Pure [Tris (Hydroxymethyl) Aminomethane], 500 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000659706.jpg-250.jpg)
Alkali Scientific Tris Base Ultra Pure [Tris (Hydroxymethyl) Aminomethane], 500 G
Tris Base Ultra Pure [Tris (Hydroxymethyl) Aminomethane], 500g, is a high-quality reagent used extensively in molecular biology and biochemistry laboratories. This ultra-pure formulation ensures minimal contaminants, making it ideal for experiments that require precise pH control and minimal interference from impurities. Tris Base is commonly used to prepare Tris-buffered solutions for protein purification, enzyme assays, and nucleic acid research. The 500g size is perfect for mid-sized laboratories or for researchers requiring consistent buffer preparation for electrophoresis, PCR, and other biochemical assays. Its ability to maintain pH stability in a wide range of conditions makes it a versatile reagent in the lab.
![Alkali Scientific Tris Base Ultra Pure [Tris (Hydroxymethyl) Aminomethane], 5 Kg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000659707.jpg-250.jpg)
Alkali Scientific Tris Base Ultra Pure [Tris (Hydroxymethyl) Aminomethane], 5 Kg
Tris Base Ultra Pure [Tris (Hydroxymethyl) Aminomethane], 5kg, is a high-purity reagent used in a variety of biochemical and molecular applications, particularly for preparing buffer solutions. Tris Base is essential for maintaining a stable pH in biological and chemical experiments, which makes it indispensable in protein analysis, electrophoresis, and enzyme activity studies. The 5kg size is ideal for larger laboratories or those involved in frequent buffer preparation. Its ultra-pure quality ensures minimal interference with sensitive experiments, making it suitable for protein purification, DNA analysis, and other molecular biology techniques where precise pH control is necessary.
![Alkali Scientific 1 O Methyl α D mannopyranoside [Methyl α D Mannopyranoside], 100 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000659627.jpg-250.jpg)
Alkali Scientific 1 O Methyl α D mannopyranoside [Methyl α D Mannopyranoside], 100 G
Methyl α-D-Mannopyranoside (100g) is a high-quality carbohydrate reagent used in laboratory experiments that require a stable and reliable source of this sugar derivative. Methyl α-D-Mannopyranoside is used in biochemical research for the study of glycosidic bonds, carbohydrate-protein interactions, and in the synthesis of oligosaccharides and glycoproteins. This reagent is commonly employed in research on carbohydrate chemistry, enzymology, and cell biology. The 100g bottle is ideal for medium to large-scale experiments, offering an essential carbohydrate derivative for researchers studying molecular interactions, glycosylation, and other sugar-related biochemical processes.