Monosaccharides
Medchemexpress LLC Dazostinag disodium | 2553413-93-5 | 98.7% | 754.48 | 500 UG
Dazostinag disodium (TAK-676) is a STING agonist that activates the STING signaling pathway and type I interferons. It acts as a modulator of the immune system, leading to complete regressions and durable memory T-cell immunity, and promotes durable IFN-dependent antitumor immunity.
- Activates the STING-TBK1-IRF3 pathway
- Exerts in vitro immune cell activation in mouse BM-derived dendritic cells
- Promotes activation of dendritic cells, natural killer cells, and T cells
- Well tolerated and shows dose-proportional pharmacokinetics in plasma
- Exhibits anti-tumor function in syngeneic tumors in mice
- Induces dose-dependent cytokine responses, increasing activation and proliferation of immune cells
Medchemexpress LLC Fludarabine (phosphate) | 75607-67-9 | 99.8% | C10H13FN5O7P | 50 MG
Fludarabine phosphate is an analogue of adenosine and deoxyadenosine. It competes with dATP for incorporation into DNA and inhibits DNA synthesis. This compound significantly reduces cell viability in a dose-dependent manner.
- Competes with dATP for incorporation into DNA
- Inhibits DNA synthesis
- Significantly reduces cell viability in a dose-dependent manner
- Causes complete regression of D54 tumors in mice
- For research use only
Medchemexpress LLC Olsalazine Disodium | 6054-98-4 | 99.8% | 1 ML
Olsalazine Disodium is an orally active prodrug of 5-ASA. It can inhibit cell proliferation, induce apoptosis, reduce DAI and MPO activity, and inhibit inflammatory cytokine levels. This product is used in research for cancer, inflammation, and metabolic diseases, including colorectal cancer, inflammatory bowel disease (IBD), and hyperuricemia.
- Orally active prodrug of 5-ASA
- Inhibits cell proliferation
- Induces apoptosis
- Reduces DAI and MPO activity
- Inhibits inflammatory cytokine levels
- Used in research for cancer, inflammation, and metabolic diseases
Apexbio Technology LLC Balsalazide-disodium-diH2O
Balsalazide disodium dihydrate (CAS No 150399-21-6) is a prodrug commonly used in biomedical research focused on gastrointestinal conditions like ulcerative colitis Originating from efforts to reduce inflammation its mechanism involves releasing the active 5-aminosalicylic acid (5-ASA) in the colon which inhibits the production of inflammatory mediators such as leukotrienes and prostaglandins In vitro it shows activity in the nanomolar to low micromolar range indicating its efficacy in modulating inflammatory pathways Typical applications include studies using cell models like colon epithelial cells and animal studies aimed at understanding its therapeutic potential It is also explored in drug screening for new anti-inflammatory agents Experimental concentrations typically depend on the specific research design allowing flexibility in dosage depending on the experimental setup and objective