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Monosacharides with a carboxyl group at one or both ends of their chain; includes aldonic, ulosonic, uronic, and aldaric acids; may act as sequestering agents and binders, corrosion inhibitors, biodegradable chelators for pharmaceuticals, or pH regulators.
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Heparin sodium salt from porcine intestinal mucosa Grade I-A, ≥180 USP units/mg, powder, BioReagent, suitable for cell culture, 10000units. Heparin is mainly responsible for the delay in the coagulation of blood. It enhances the antithrombin-mediated inactivation of proteases in the coagulation pathway.
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HiTrap(R) Heparin HP columns are prepacked with Heparin Sepharose(R) High Performance for high-reSOLUTIONon purification of proteins with affnity for heparin such as DNA-binding proteins coagulation factors lipoproteins and protein synthesis factors.Immobilized heparin has two main modes of interaction with proteins. It can operate as an affinity ligand with affinity for a wide range of biomolecules including coagulation factors and other plasma proteins lipoproteins protein synthesis factors enzymes that act on nucleic acids and steroid receptors. Heparin also functions as a high capacity cation exchanger due to its anionic sulfate groups. Gradient elution with salt is most commonly used in both cases.Heparin is coupled to the Sepharose(R) High Performance base matrix via the N-hydroxysuccinamide coupling method to give high capacity performance and low leakage levels.
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HiPrep(TM) Heparin FF 16/10 is prepacked with Heparin Sepharose(R) 6 Fast FLow for preparative purification of proteins with affinity for heparin such as DNA-binding proteins coagulation factors lipoproteins and protein synthesis factors.
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Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Patient derived organoids (PDOs) are novel in vitro 3D cell models that preserve original tissue physiology and molecular pathology thus representing a clinically-relevant alternative to traditional 2D cell lines and an effective tool to refine and reduce animal models. PDOs can be derived from adult patient biopsies or resected tissues containing native LGR5 stem cell populations and cultured within an ECM-rich substrate using specialized organoid media such as L-WRN conditioned media. Adult tissue derived organoids are phenotypically and genetically stable in long term culture presenting more mature phenotypes compared to iPSC-derived organoids. Importantly PDOs have shown to be able to predict patient clinical responses to chemotherapeutics.We are now offering a comprehensive biobank of highly characterized tissue-derived human gastrointestinal organoids from normal and diseased patients. The intestinal organoid biobank contains over 50 highly characterized intestinal organoids f
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
The Sialic Acid Quantitation Kit provides a rapid and accurate determination of total N-acetylneuraminic acid (NANA sialic acid). NANA is released from glycoconjugates using neuraminidase. The kit uses alpha(2-3 6 8 9) neuraminidase to cleave all NANA linkages including alpha(2-8) and alpha(2-9) linkages as well as branched NANA for the most accurate determination of total sialic acid content.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More