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Filtered Search Results
Medchemexpress LLC L-allylglycine hydrochloride | 195316-72-4 | MFCD06797042 | 98.0% | 151.59 g/mol | C5H10ClNO2 | 1 G
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L-allylglycine hydrochloride is the hydrochloride salt of L-allylglycine, an amino acid derivative that functions as a glutamate decarboxylase (GAD) inhibitor. It reduces GABA biosynthesis and is used in neuroscience research to model GABAergic disruption and convulsant activity.
- Inhibits glutamate decarboxylase (GAD), decreasing GABA production.
- Useful as a research tool to study GABAergic pathways and seizure mechanisms.
- Provided as a hydrochloride salt for improved solubility in aqueous media.
- Available in small research-scale quantities suitable for experimental use.
- Characterized by formula C5H10ClNO2 and molecular weight 151.59 g/mol.
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Medchemexpress LLC L-Allylglycine | 16338-48-0 | MFCD00002627 | ≥98.0% | 115.13 | 25 G
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L-Allylglycine (L-2-Allylglycine) is an amino acid derivative that functions as an inhibitor for glutamate decarboxylase (GAD), thereby reducing GABA biosynthesis in the brain. It exhibits convulsant activity and is intended for research use only. Studies have shown that L-Allylglycine induces convulsive behaviors in Sprague-Dawley rat models, reducing GABA content in the hippocampus, cortex, and cerebellum, and inducing running fits, partial rigidity, and convulsions.
- Inhibits glutamate decarboxylase.
- Reduces GABA biosynthesis in the brain.
- Exhibits convulsant activity.
- Induces convulsive behaviors in rat models.
- Reduces GABA content in various brain regions.
- For research use only.
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AdipoGen Itaconic acid (1 g)
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Chemical. CAS: 97-65-4. Formula: C5H6O4. MW: 130.1. Mammalian antibacterial metabolite. Inhibitor of isocitrate lyase, the key enzyme of the glyoxylate cycle, essential for bacterial growth. Antimicrobial. Antibacterial. Inhibits the growth of bacteria expressing isocitrate lyase. Phosphofructokinase (PFKII) inhibitor. Suppresses glycolysis by decreasing the level of fructose 2,6-bisphosphate, resulting in decreased visceral fat. Might be involved in the regulation of metabolism. One of the most highly induced metabolites in activated macrophages. Exerts anti-inflammatory effects in vitro and in vivo. Regulates succinate levels by inhibiting succinate dehydrogenase (SDH). Regulates mitochondrial respiration and cytokine production. Might induce inflammasome activation and consequently IL-1beta secretion by generating ROS.
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Matrix Scientific BOC-L-ALLYLGLYCINE . DCHA-1G
Boc-L-allylglycine . DCHA, 1g,C22H40N2O4, MFCD01321013, mw 396.58, [143979-15-1]
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Medchemexpress LLC Itaconic acid | 97-65-4 | MFCD00004260 | 100.0% | 130.10 g/mol | C5H6O4 | 100mg
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Itaconic acid (Standard) is the analytical standard of Itaconic acid This product is intended for research and analytical applications Itaconic acid a precursor of polymers chemicals and fuels can be synthesized by many fungi Itaconic acid also is a macrophage-specific metabolite Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors Itaconic acid has anti-inflammatory anti-microbial and immunomodulatory effect[1][2][4][5]
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Medchemexpress LLC N-Propargylglycine | 58160-95-5 | 99.7% | C5H7NO2 | 25 MG
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N-Propargylglycine is a brain-penetrant, orally active PRODH inhibitor. It works by covalently modifying enzyme-bound FAD and active site lysine, leading to enzyme structural distortion, protein decay, and irreversible inhibition of proline and 4-hydroxyproline catabolism. It can induce UPRmt, upregulate mitochondrial chaperones, and enhance mitochondrial proteostasis.
- Brain-penetrant and orally active.
- Irreversibly inhibits proline oxidation.
- Induces mitochondrial unfolded protein response.
- Blocks astrocytic L-proline consumption.
- Stimulates neural processes and increases brain amino acid levels.
- Reduces hyperoxaluria and prevents calcium oxalate stone formation.
- Used in research for breast cancer, neurodegenerative disorders, and primary hyperoxaluria.
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eMolecules Boc-D-allylglycine | 170899-08-8 | MFCD01320882 | 1g
Combi-Blocks | Boc-D-allylglycine | 1g | 267175863 | QC-1062 | 97.000 | 170899-08-8 | MFCD01320882 | 215.249 | C10H17NO4
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Medchemexpress LLC N-Propargylglycine | 58160-95-5 | 99.7% | C5H7NO2 | 10MM/1ML
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N-Propargylglycine is a brain-penetrant, orally active PRODH inhibitor. It irreversibly inhibits proline and 4-hydroxyproline catabolism by covalently modifying enzyme-bound FAD and active site lysine. This compound induces UPRmt, upregulates mitochondrial chaperones, and enhances mitochondrial proteostasis. It also stimulates neural processes, increases brain proline levels, and normalizes Huntington's disease transcriptomes. Additionally, N-Propargylglycine reduces hyperoxaluria and prevents calcium oxalate stone formation.
- Brain-penetrant and orally active PRODH inhibitor
- Irreversible inhibition of proline catabolism
- Enhances mitochondrial proteostasis
- Stimulates neural processes; increases brain proline
- Normalizes Huntington's disease transcriptomes
- Reduces hyperoxaluria; prevents calcium oxalate stones
- Research applications include breast cancer and neurodegenerative disorders
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Apexbio Technology LLC Itaconic acid 97-65-4 500mg
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Itaconic acid (CAS 97-65-4) is a dicarboxylic acid commonly investigated for its role as a monomer in biomedical research Its incorporation in the polymerization processes such as with polyacrylonitrile (PAN) facilitates the thermo-oxidative stabilization of resulting polymers by promoting cross-linking and enhancing structural integrity under oxidative conditions This property is significant in the development of advanced biomaterials including tissue engineering scaffolds and drug delivery systems Itaconic acid s chemical reactivity and compatibility with various polymer matrices make it valuable for studies focusing on material modification and functionalization
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eMolecules Itaconic anhydride | 2170-03-8 | MFCD00005530 | 5g
Oakwood Chemicals | Itaconic anhydride | 5g | 480167222 | 358473 | | 2170-03-8 | MFCD00005530 | 112.084 | C5H4O3
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Medchemexpress LLC L-allylglycine hydrochloride | 195316-72-4 | MFCD06797042 | 98.0% | 151.59 g/mol | C5H10ClNO2 | 5 G
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L-Allylglycine hydrochloride is the hydrochloride salt of the amino acid derivative L-allylglycine. It functions as an inhibitor of glutamate decarboxylase (GAD), reducing GABA biosynthesis, and is used in neuroscience and biochemical research. The compound is supplied as a solid powder with reported purity of 98% and is intended for laboratory research use only.
- Inhibits glutamate decarboxylase (GAD), reducing GABA synthesis.
- Hydrochloride salt form improves solubility for aqueous studies.
- High purity (98.0%) suitable for research applications.
- Available in small-scale sizes for method development and testing.
- Provided with batch-specific certificate of analysis for traceability.
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AdipoGen Itaconic acid Itaconate
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Chemical. CAS 97-65-4. Formula C5H6O4. MW 130.1. Mammalian antibacterial metabolite. Inhibitor of isocitrate lyase, the key enzyme of the glyoxylate cycle, essential for bacterial growth. Antimicrobial. Antibacterial. Inhibits the growth of bacteria expressing isocitrate lyase. Phosphofructokinase PFKII inhibitor. Suppresses glycolysis by decreasing the level of fructose 2,6-bisphosphate, resulting in decreased visceral fat. Might be involved in the regulation of metabolism. One of the most highly induced metabolites in activated macrophages. Exerts anti-inflammatory effects in vitro and in vivo. Regulates succinate levels by inhibiting succinate dehydrogenase SDH. Regulates mitochondrial respiration and cytokine production. Might induce inflammasome activation and consequently IL-1beta secretion by generating ROS.
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AdipoGen Itaconic acid 4-octyl ester
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Chemical. CAS 3133-16-2. Formula C13H22O4. MW 242.3. Derivative of itaconate AG-CN2-0426 https//adipogen.com/ag-cn2-0426-itaconic-acid.html with enhanced cell permeability. Prodrug that is efficiently metabolized to itaconate in cells. Potent anti-inflammatory agent. In vitro it activates the transcription factor nuclear factor erythroid 2-related factor 2 Nrf2 also known as NFE2L2 in LPS-induced mouse and human macrophages. Upregulates Nrf2 levels via a newly identified post-translational modification, dicarboxylation of KEAP1. Alkylates cysteine residues 151, 257, 288, 273 and 297 on the protein KEAP1, enabling Nrf2 to increase the expression of downstream gene. Cysteine 151 is uniquely required for inhibiting KEAP1-mediated degradation of Nrf2 and mutating this residue in KEAP1 prevents the stabilization of Nrf2.
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eMolecules EMOLECULES INC
5000482842 4-PENTYNOIC ACID 25G
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eMolecules EMOLECULES INC
5000482843 4-PENTYNOIC ACID 1G
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