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C20 Ceramide, also known as N-Arachidoyl-D-sphingosine, is a natural 20:0 ceramide. This N-acylsphingosine has its N-acyl group specified as eicosanoyl, functioning as a vital signal molecule.
Mediates cell growth
Influences cell differentiation
Involved in cell senescence
Regulates apoptosis
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Sphingomyelin is a eukaryotic sphingolipid and one of the major constituents of cell membranes and particularly abundant in the myelin sheath that surrounds neuronal axons. Sphingomyelin plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction. Sphingomyelin metabolism is associated with various central nervous system diseases and Niemann-Pick disease.
In vitro: Sphingomyelin metabolism results in the production of various interconvertible bioactive sphingolipids or derivatives such as ceramide, diacylglyceride, and sphingosine-1-phosphate. These bioactive lipids act on their specific targets within the cell and regulate various signal transduction pathways, thereby affecting cellular functions. Sphingomyelin enriched lipid raft mediated cell signaling.
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