Steroids and derivatives
Medchemexpress LLC Glycocholic acid | 475-31-0 | 465.62 | 10 G
Glycocholic acid is a bile acid with anticancer activity, targeting against pump resistance-related and non-pump resistance-related pathways. It works by modulating P-gp and MRPs, and regulating apoptosis-related pathways when combined with anticancer drugs.
- Increases cytotoxicity of epirubicin
- Increases intracellular accumulation and absorption of epirubicin
- Intensifies epirubicin-induced apoptosis
- Reduces mRNA expression levels of human intestinal MDR1, MDR-associated protein (MRP)1, and MRP2
- Downregulates the MDR1 promoter region
- Suppresses mRNA expression of Bcl-2
- Induces mRNA expression of Bax
- Increases Bax-to-Bcl-2 ratio and mRNA levels of p53, caspase-9 and -3
Cayman Chemical Prostaglandin E2d4 MaxSpec S
A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
Cambridge Isotope Laboratories ( )-trans-3-Hydroxycotinine (unlabeled) 100 ug/mL in acetonitrile 1 2 mL
( )-trans-3-Hydroxycotinine (unlabeled) 100 ug/mL in acetonitrile 1 2 mL
Selleck Chemical LLC Glycocholic acid S4958-25mg
Glycocholic acid (Cholylglycine Glycocholate) is a natural secondary bile acid involved in the emulsification of fats
Medchemexpress LLC Dexamethasone 21-acetate | 1177-87-3 | 98.9% | 434.50 | 100 MG
Dexamethasone acetate (Standard) is the analytical standard for Dexamethasone acetate, intended for research and analytical applications. It acts as a glucocorticoid receptor agonist.
- Decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes.
- Effective in controlling COVID-19 infection.
- Inhibits the production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.
- Suitable as a reference standard for assays.
- Commonly used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
Medchemexpress LLC Dexamethasone | 50-02-2 | MFCD00064136 | C22H29FO5 | 10MG
Dexamethasone is a synthetic glucocorticoid receptor agonist provided as a GMP-grade small molecule for research and analytical applications. The GMP material is intended as an auxiliary reagent in regulated cell therapy workflows and is offered in small pack sizes for analytical or process development use.
- Agonist of the glucocorticoid receptor.
- Provided as GMP grade for use in regulated workflows.
- Intended as an auxiliary reagent for cell therapy manufacture.
- Available in small pack sizes suitable for analytical use.
- CAS number 50-02-2; molecular formula C22H29FO5.
Apexbio Technology LLC CEFOTAXIME-D3-1MG
Cefotaxime-d3 (CAS No 63527-52-6) is a deuterated antibiotic used primarily in pharmacokinetic studies and drug development research As a third-generation cephalosporin it originates from modifications of the beta-lactam antibiotic class targeting bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) This disrupts the bacterial cell wall structure leading to cell lysis In vitro activity typically falls within the nanomolar to low micromolar range making it effective in various microbiological research settings Common applications include studies using bacterial cultures cell models and animal studies to evaluate antibacterial efficacy and resistance profiles It is also employed in drug screening processes to assess pharmacokinetic parameters and the metabolism of cephalosporins Experimental concentrations typically depend on the specific research design
Apexbio Technology LLC CEFPODOXIME-D3-1MG
Cefpodoxime-d3 (CAS No 2477791-28-7) is a deuterated version of the third-generation cephalosporin antibiotic cefpodoxime used primarily in biomedical research to study its pharmacokinetics and metabolic pathways Originating from modifications of the standard cefpodoxime molecule it retains similar antibacterial activity by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins effectively disrupting cell wall biosynthesis Typically exhibiting in vitro activity in the nanomolar to low micromolar range it is employed in various experimental setups including cell models and animal studies to investigate its efficacy and safety profile This compound is also pertinent in drug screening scenarios where detailed metabolic and pharmacokinetic data are required Experimental concentrations typically depend on the specific research design allowing flexibility for various investigative frameworks
Medchemexpress LLC 3-O-Methyldopa-d3 hydrate | 300-48-1 | 232.25 | 1 MG
3-O-Methyldopa-d3 (hydrate) is the deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa (3-Methoxy-L-tyrosine) hydrate is a metabolite of L-DOPA that can cross the blood-brain barrier (BBB). 3-O-Methyldopa hydrate inhibits the astrocyte-mediated protective effect of L-DOPA on dopaminergic neurons. In addition, 3-O-Methyldopa hydrate has certain antidepressant and neuroprotective activities. 3-O-Methyldopa hydrate can be used in the research of nervous system diseases such as depression and Parkinson's disease.
- This compound can be used as a tracer.
- This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.