Steroids and derivatives
Medchemexpress LLC Estra-1,3,5(10)-triene-3,17-diol (17β)-, 17-(hydrogen butanedioate) | 7698-93-3 | 98.8% | 372.45 | 50 MG
β-Estradiol 17-hemisuccinate is a synthetic derivative of estradiol, appearing as a white to off-white solid.
- Synthetic derivative of estradiol.
- CAS number: 7698-93-3.
- Molecular weight: 372.45.
- Chemical formula: C22H28O5.
- Purity: 98.8%.
- Store at 4°C, stored under nitrogen.
- Store in solvent at -80°C for 6 months or -20°C for 1 month, stored under nitrogen.
- 1H NMR spectrum and LCMS consistent with structure.
Medchemexpress LLC Estra-1,3,5(10)-triene-2,4,16,16-d4-3,17-diol, 3-(hydrogen sulfate), sodium salt, (17a)- | 352431-50-6 | 99.6% | 378.45 g/mol | C18H19D4NaO5S | 5 MG
17β-Estradiol sulfate-d4 (sodium) is a deuterium-labeled sodium salt of 17β-estradiol 3-sulfate supplied as a high-purity analytical standard for research use. It is intended as an internal standard or tracer in mass spectrometry and other quantitative assays to study estradiol metabolism and sulfate conjugates.
- Deuterium-labeled (d4) analog for isotope dilution and tracer studies.
- Sodium salt supplied as a solid, suitable for long-term storage.
- High purity (~99.6%) for analytical applications.
- Molecular formula C18H19D4NaO5S; molecular weight 378.45 g/mol.
- For research use only; not for human or clinical use.
Cayman Chemical Ethynyl Estradiol
An estrogen receptor agonist (EC50 = 8.5 pM in a reporter assay using T47D cells); reduces serum cholesterol levels and femur bone mass and increases uterine mass in an OVX rat model of postmenopause at 0.1 mg/kg per day; has been found in wastewater effluent; prevents secondary sexual development in male fathead minnows and increases the numbers of intersex fish at 4 ng/l
Medchemexpress LLC Estradiol cypionate | 313-06-4 | MFCD00056558 | 99.5% | 1 ML
Estradiol cypionate is the 17β-cypionate ester of Estradiol, inhibiting ET-1 synthesis by acting on estrogen receptors. It is intended for research use only. In vitro, it inhibits proliferation of gastric cancer cells and induces G1/S phase cell cycle arrest and apoptosis by affecting the PI3K/Akt/mTOR pathway. In vivo, it increases cortical bone density in ovariectomized rabbits, increases occurrence of estrus and pregnancy in cows, and inhibits tumor growth in MGC803 nude mice tumor models.
- Inhibits gastric cancer cell proliferation
- Induces G1/S phase cell cycle arrest and apoptosis
- Increases cortical bone density
- Promotes estrus and pregnancy
- Inhibits tumor growth
Apexbio Technology LLC α-Estradiol 57-91-0 10mM (in 1mL Ethanol)
alpha-Estradiol (57-91-0) is a small-molecule inhibitor targeting 5 -reductase the enzyme responsible for converting testosterone to dihydrotestosterone (DHT) It is designed to inhibit 5 -reductase activity thereby modulating androgen metabolism and androgen-related signaling pathways alpha-Estradiol exerts its biological activity primarily through enzyme inhibition In reported experimental studies alpha-Estradiol demonstrates inhibitory activity against 5 -reductase with an IC50 value ranging from approximately 1 to 10 M though the precise value may depend on assay conditions Based on these pharmacological properties alpha-Estradiol holds research potential in the treatment and study of androgenetic alopecia
Medchemexpress LLC Alpha-estradiol | 57-91-0 | MFCD00064144 | 99.9% | 272.39 | C18H24O2 | 10 MG
Alpha-estradiol (analytical standard) is a reference material intended for analytical testing and method development. It is a weak estrogen and a 5α-reductase inhibitor supplied as a high-purity solid suitable for calibration, qualitative analyses, and quantitative assays in research and laboratory workflows.
- Analytical reference standard for research and method validation.
- High stated purity for accurate calibration (99.93%).
- Supplied as a solid for convenient handling and storage.
- Available in small pack sizes appropriate for analytical use (10 mg).
- Applicable to studies of estrogenic activity and 5α-reductase inhibition.
Cambridge Isotope Laboratories Estradiol (unlabeled) 100 ug/mL in acetonitrile 1 2 mL
Estradiol (unlabeled) 100 ug/mL in acetonitrile 1 2 mL
Medchemexpress LLC β-estradiol-6-CMO-PEG3-biotin | 2938875-38-6 | 97.8% | 759.95 g·mol⁻¹ | C38H57N5O9S | 1 MG
β-Estradiol-6-CMO-PEG3-biotin is a biotinylated estradiol derivative used as a cleavable three-unit polyethylene glycol (PEG3) linker for antibody-drug conjugate (ADC) synthesis. It provides a hydrophilic spacer and a biotin handle to facilitate conjugation, affinity capture, and detection in downstream assays.
- Cleavable three-unit PEG linker providing hydrophilicity and spacing.
- Biotin tag enables affinity capture and detection.
- High purity (97.82%) suitable for research applications.
- Soluble in DMSO at ≥ 50 mg/mL; use freshly opened DMSO.
- Stable as a powder at -20°C for up to 3 years; limited stability in solvent as specified by manufacturer.
Sigma Aldrich Fine Chemicals Biosciences beta-Estradiol 17-beta-D-g10MG
BETA7 beta-Estradiol 17-beta-D-g10MG
Cayman Chemical Ethynyl Estradiol
An estrogen receptor agonist (EC50 = 8.5 pM in a reporter assay using T47D cells); reduces serum cholesterol levels and femur bone mass and increases uterine mass in an OVX rat model of postmenopause at 0.1 mg/kg per day; has been found in wastewater effluent; prevents secondary sexual development in male fathead minnows and increases the numbers of intersex fish at 4 ng/l
Cayman Chemical 17-EstradIol-d3 1mg
An internal standard for the quantification of 17β-estradiol by GC- or LC-MS
Medchemexpress LLC Estradiol (Standard) | 50-28-2 | 99.9% | 1 ML
Estradiol (β-Estradiol) is a steroid hormone and the primary female sex hormone. It can increase the expression of neural markers in human endometrial stem cells (hEnSCs) and promote their neural differentiation. This product is intended for research use only and is utilized in studies concerning cancers, neurodegenerative diseases, and neural tissue engineering.
- Increases expression of neural markers in human endometrial stem cells.
- Promotes neural differentiation of human endometrial stem cells.
- Utilized in research for cancers, neurodegenerative diseases, and neural tissue engineering.
- Increases SIRT1 protein levels in C2C12 cells.
- Increases FoxL2 and pFoxL2 protein expression levels in ZF4 cells.
- Promotes proliferation of sheep myoblasts.
- Enhances expression of ERRα and VLDL-related genes in primary hepatocytes.
- Induces mRNA expression of pS2 and NRF1 genes in MCF-7 cells.
Gold Biotechnology Inc Digitonin Special Grade
Digitonin is a nonionic saponin steroid derived from the plant Digitalis purpurea It is useful for creating Digitonin-cholesterol complexes which form when Digitonin disrupts the cell membrane and binds with cholesterol in a nearly 1 1 stoichiometric ratio When precipitated from ethanolic solutions these complexes form flat lamellar sheets Digitonin s cholesterol displacing properties have been used in newer applications to quantify the rate of lysosomal membrane permeabilization (LMP) a new technique developed to bypass traditional cell death pathways Digitonin permeabilizes plasma membranes but leaves lysosomal membranes intact allowing for a quantifiable measurement of lysosomal hydrolases and comparison to normal cellular enzyme activity Digitonin has been shown to induce hemolysis in red blood cells
Medchemexpress LLC Estradiol-d3 | 79037-37-9 | 98.6% | 5 MG
Estradiol-d3 is a deuterium-labeled form of Estradiol, a steroid sex hormone crucial for maintaining fertility and secondary sexual characteristics in females. It upregulates IL-6 expression via the estrogen receptor β (ERβ) pathway and is intended for research use only. This compound serves as a tracer and internal standard for quantitative analysis, leveraging the potential of deuteration to influence pharmacokinetic and metabolic profiles.
- Used as a tracer
- Used as an internal standard for quantitative analysis (NMR, GC-MS, LC-MS)
- Deuteration influences drug pharmacokinetic and metabolic profiles
- Appears as a white to off-white solid
- Molecular weight: 275.40
- Chemical formula: C18H21D3O2
- Powder storage: -20°C for 3 years or 4°C for 2 years
- Solvent storage: -80°C for 6 months or -20°C for 1 month
- Soluble in DMSO (50 mg/mL) and ethanol (20 mg/mL)
Medchemexpress LLC Estradiol 3-glucuronide sodium | 14982-12-8 | 1 MG
Estradiol 3-glucuronide sodium is an estrogen metabolite, a glucuronide conjugate formed in tissues like the liver from Estradiol. It is a potent substrate of Mrp2, achieving hepatobiliary transport in hepatocytes via basolateral uptake through OATP1B1, OATP1B3, and OATP2B1, and apical efflux via MRP2 and BCRP. For research use only.
- Substrate for OATP1B1, OATP1B3, and OATP2B1 in HEK293T cells.
- Uptake inhibited by OATP substrates and inhibitors.
- Inhibits OATP1B3- and OATP2B1-mediated estrone-3-sulfate uptake.
- Inhibits OATP1B1-, OATP1B3-, OATP2B1-mediated Rosuvastatin uptake.
- Substrate of rat Mrp2 in Sf9 cell membrane vesicles.
- Competitively inhibits rat Mrp2-mediated Estradiol 17-glucuronide transport.
- Used to produce high-affinity antiserum for radioimmunoassay in urine samples.