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Nucleosides and nucleotides containing a nucleic acid analogue (a compound structurally similar to naturally occurring RNA or DNA); analogous nucleobases typically possess, among other things, different base pairing and base stacking properties.
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Rp-cAMPS sodium salt is a cAMP analog that competitively antagonizes cAMP-dependent protein kinase A (PKA) I and II and is resistant to hydrolysis by phosphodiesterases, intended for biochemical and cell signaling research applications.
High purity (≈99.7%) suitable for biochemical assays.
Molecular formula C10H11N5NaO5PS and molecular weight 367.25 g/mol.
Resistant to hydrolysis by phosphodiesterases.
Reported Ki values ~6.05 μM (PKA I) and ~9.75 μM (PKA II).
Solid, white to pink appearance; available as solid or solution (10 mM in DMSO).
Storage: -20°C sealed; in solvent -80°C (6 months) or -20°C (1 month).
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Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor used for treatment of chronic HBV and HIV/AIDS It works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase
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Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). It can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the central nervous system (CNS). It appears as a solid and has a molecular weight of 229.26. Its identified uses include laboratory chemicals and the manufacture of substances.
Orally active nucleoside reverse transcriptase inhibitor
Inhibits HIV reverse transcriptase 1/2
Inhibits reverse transcriptase of hepatitis B virus
Salicylate form can penetrate the CNS
Solid appearance
Molecular weight of 229.26
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Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). It is capable of inhibiting both HIV reverse transcriptase 1/2 and the reverse transcriptase of hepatitis B virus. Additionally, lamivudine salicylate has the ability to penetrate the central nervous system (CNS).
Orally active nucleoside reverse transcriptase inhibitor (NRTI)
Inhibits HIV reverse transcriptase 1/2
Inhibits reverse transcriptase of hepatitis B virus
Salicylate form can penetrate the CNS
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Lamivudine is a nucleoside analog that acts primarily as a reverse transcriptase inhibitor disrupting viral replication by interfering with RNA-dependent DNA polymerase activity It inhibits human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with an IC50 value of approximately 0 316 M Lamivudine also suppresses replication of simian retrovirus (SRV-1 and SRV-2) while exhibiting negligible activity on foamy viruses and amphotropic murine leukemia virus (MLV-A) Due to its antiviral mechanism and dual inhibitory effect against both HIV-1 and hepatitis B virus (HBV) lamivudine is frequently utilized in research involving retroviral infection models particularly HIV-1 and HBV coinfection studies to evaluate viral dynamics antiviral efficacy and biochemical responses
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More