Purine nucleotides
Medchemexpress LLC 8-azidoadenosine 5'-triphosphate trisodium | 00-00-0 | 98.1% | C10H12N8Na3O13P3 | 10MG
8-Azido-ATP trisodium is a photoreactive adenosine triphosphate analog used for photoaffinity labeling and identification of ATP-binding proteins and nucleotide-interacting enzymes. Supplied as the trisodium salt with high purity (98.1%), it is intended for research applications involving UV-activated crosslinking to probe protein-nucleotide interactions.
- Photoreactive azido group enables UV-activated crosslinking to binding partners.
- Suitable for identifying ATP-binding proteins and nucleotide-interacting enzymes.
- Available as the water-soluble trisodium salt for aqueous assays.
- High purity suitable for analytical and biological experiments.
- Compatible with downstream identification techniques such as SDS-PAGE and mass spectrometry.
Medchemexpress LLC Adenosine antagonist-1 | 431040-19-6 | 99.8% | 359.41 g/mol | C18H13N7S | 25 MG
Adenosine antagonist-1 is a small-molecule adenosine A3 receptor (A3R) antagonist reported to have anti-inflammatory activity for in vitro and preclinical research. The compound is supplied as a white to off-white solid with molecular formula C18H13N7S and molecular weight 359.41 g/mol. Typical purity is 99.79% and the material is provided in milligram-scale quantities for laboratory studies.
- Acts as an adenosine A3 receptor antagonist with anti-inflammatory activity.
- High chemical purity (99.79%) suitable for research applications.
- Molecular formula C18H13N7S; molecular weight 359.41 g/mol.
- Available in milligram-scale quantities for in vitro and preclinical studies.
- Supplied as a white to off-white solid for easier handling and storage.
Apexbio Technology LLC Adenosine Kinase Inhibitor (hydrate) 10mg
Adenosine Kinase Inhibitor (hydrate) is a small-molecule inhibitor targeting adenosine kinase It is designed to inhibit adenosine kinase thereby regulating intracellular adenosine metabolism Adenosine Kinase Inhibitor (hydrate) exerts its biological activity primarily through selective enzyme inhibition In cell-free conditions Adenosine Kinase Inhibitor (hydrate) demonstrates potent inhibitory activity with an IC50 value of approximately 1 7 nM Based on these pharmacological properties Adenosine Kinase Inhibitor (hydrate) holds research potential in investigating pain perception mechanisms and inflammation modulation through adenosine signaling pathways
Apexbio Technology LLC 2'-O-Methyl-N6-Methyl-ATP 100ul (100 mM)
2p-O-Methyl-N6-Methyl-ATP is a chemically modified ATP analog bearing methyl substitutions at the N6 position of adenine and the 2 -hydroxyl group of the ribose sugar 2p-O-Methyl-N6-Methyl-ATP is designed to facilitate the study of RNA methylation processes and RNA protein interactions supporting the mechanistic exploration of RNA-modifying enzymes and epigenetic regulatory pathways Based on these properties 2p-O-Methyl-N6-Methyl-ATP holds research potential in investigations of ligand RNA interactions and drug discovery applications targeting RNA-related biological processes
Medchemexpress LLC Adenosine 5'-monophosphate monohydrate | 18422-05-4 | 99.8% | C10H16N5O8P | 5 G
Adenosine 5'-monophosphate monohydrate is an adenosine A1 receptor agonist. It demonstrates significant antiviral activity against HSV-1 and HSV-2. In vitro studies show that its cell toxicity is negligible at concentrations of 25 to 400 μM in RAW264.7 cells.
- Negligible cell toxicity at 25 to 400 μM in RAW264.7 cells
- Attenuates mRNA expression of TNF-α and IL-6 in RAW264.7 cells
- Reduces NF-κB p65 recruitment to TNF-α, IL-6, and IL-1β gene promoters
- Increases hepatic adenosine levels and improves survival rates in mice
- Lowers serum AST and ALT levels, reduces liver necrosis and inflammatory cell infiltration
Medchemexpress LLC 4 -tert-Butylacetoph 10mM 1mL | 10MM/1ML
4 -tert-Butylacetoph 10mM 1mL | 10MM/1ML
Apexbio Technology LLC Motesanib Diphosphate (AMG-706) 857876-30-3 10mM (in 1mL DMSO)
Motesanib Diphosphate (AMG-706 CAS 857876-30-3) is an oral small-molecule ATP-competitive inhibitor that targets vascular endothelial growth factor receptors (VEGFR1/2/3) platelet-derived growth factor receptor (PDGFR) c-Kit and Ret with reported IC50 values of 2 84 nM It demonstrates over 1000-fold selectivity for VEGFRs relative to EGFR Src and p38 kinases In vitro Motesanib Diphosphate potently inhibits VEGF-induced proliferation of human endothelial cells (IC50 10 nM) and blocks PDGF- and SCF-induced signaling while showing minimal effects on bFGF-stimulated proliferation In preclinical studies it suppresses angiogenesis and induces regression in tumor xenograft models Motesanib is under investigation in anti-angiogenic cancer research
Medchemexpress LLC Adenosine 5'-monophosphate monohydrate | 18422-05-4 | 99.8% | C10H16N5O8P | 1 G
Adenosine 5'-monophosphate monohydrate | 18422-05-4 | 99.8% | C10H16N5O8P | 1 G
Medchemexpress LLC Sonidegib diphosphate | 1218778-77-8 | 99.97% | 681.49 | 10 MM 1 ML
Sonidegib diphosphate is a potent and selective Smoothened (Smo) antagonist, inhibiting the Hedgehog (Hh) pathway. It has demonstrated antitumor activity in medulloblastoma models and can reduce chronic myeloid leukemia (CML) stem cells.
- Potent and selective Smo antagonist
- Inhibits Hedgehog pathway signaling
- Reduces expression of downstream signaling targets
- Demonstrates dose-related antitumor activity
- Reduces chronic myeloid leukemia stem cells
- Associated with numerous clinical trials
Medchemexpress LLC Adenosine N1-oxide | 146-92-9 | MFCD00037993 | 99.5% | 283.24 g·mol⁻1 | C10H13N5O5 | 5 MG
Adenosine N1-oxide is a nucleoside derivative reported to have oral anti-inflammatory activity and is used in research on inflammation and cell differentiation. Supplied as a high-purity solid for laboratory use.
- High purity (99.5%) solid, white to off-white.
- Molecular weight 283.24 g·mol⁻1; formula C10H13N5O5.
- Recommended storage: powder -20°C for 3 years, 4°C for 2 years; in solvent -80°C for 6 months, -20°C for 1 month.
- Suitable for studies of osteogenic and adipocyte differentiation.
- Available in milligram quantities for research applications.
Medchemexpress LLC Adenosine monophosphate-13C10 (dilithium) | 13C10H12Li2N5O7P | 1 MG
Adenosine monophosphate-13C10 (dilithium) | 13C10H12Li2N5O7P | 1 MG
Medchemexpress LLC Kinetin triphosphate tetrasodium | 99.9% | 675.2 g/mol | C15H16N5Na4O14P3 | 5 MG
Kinetin triphosphate tetrasodium is an ATP analogue provided as the tetrasodium salt for biochemical research. It modulates kinase activity and has documented use in studies such as Parkinson's disease research. Supplied as a small, concentrated vial suitable for in vitro kinase assays and mechanistic studies.
- High purity (99.92%).
- Supplied as the tetrasodium salt, water-soluble for aqueous assays.
- Provided in small vial sizes (5 mg; 100 mM when dissolved as indicated by supplier).
- Suitable for kinase activity assays and mechanistic studies.
- Datasheet, certificate of analysis, and safety data sheet available for quality and safety information.