Purine nucleotides
Apexbio Technology LLC Primaquine Diphosphate 63-45-6 10mM (in 1mL DMSO)
Primaquine Diphosphate is an 8-aminoquinoline derivative utilized primarily as an antimalarial agent targeting the extraerythrocytic liver stage of malaria parasites While its precise IC50 values remain unspecified primaquine s biological activity involves interference with nucleic acid function subsequently disrupting protein synthesis pathways and lipid biosynthesis and inducing membrane disturbances In vitro primaquine has been applied in cell culture models to investigate antiviral effects demonstrating dose-dependent inhibition of Newcastle disease virus replication and modulation of viral RNA synthesis In vivo experiments using radiolabeled primaquine-loaded liposomes in murine models illustrate pronounced hepatic accumulation Clinically this compound is employed as prophylaxis against malaria infections (e g Plasmodium falciparum and P vivax)
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 10mM (in 1mL DMSO)
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Apexbio Technology LLC LDE225 Diphosphate 1218778-77-8 5mg
LDE225 Diphosphate (CAS 1218778-77-8) is a highly potent and selective antagonist of the Smoothened (Smo) receptor a seven-transmembrane protein involved in the Hedgehog (Hh) signaling pathway LDE225 inhibits Smo with IC50 values of 1 3 nM for murine and 2 5 nM for human Smo resulting in suppression of Hh signaling This pathway is implicated in cellular differentiation proliferation and oncogenesis In vitro LDE225 selectively binds Smo inhibiting Hh-dependent tumor cell growth In vivo it demonstrates dose-dependent antitumor efficacy in medulloblastoma xenograft mouse models LDE225 continues to be explored as a research tool and therapeutic candidate in Hh pathway-driven malignancies
Medchemexpress LLC ATP Citrate Lyase Antibody (YA596) | 121 kDa | 10 UL
ATP Citrate Lyase Antibody (YA596) is a rabbit host antibody reactive with human and mouse samples. It is supplied as a liquid at 1 mg/mL and is suitable for various applications including Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunoprecipitation, and Flow Cytometry.
- Rabbit host antibody
- Reacts with human and mouse samples
- Supplied as a liquid at 1 mg/mL
- Applications: Western Blot, ICC/IF, IHC-P, IP, FC
- Formulated in 1*TBS (pH7.4), 0.05% BSA and 40% Glycerol
- Contains 0.05% Sodium Azide preservative
- Stored at -20°C for 1 year
- Avoid repeated freeze / thaw cycles
Medchemexpress LLC Adenosine 5'-(tetrahydrogen triphosphate), magnesium salt (1:2) | 74804-12-9 | 98.0% | 1 G
ATP dimagnesium (Adenosine 5'-triphosphate dimagnesium) is a central component of energy storage and metabolism. It provides metabolic energy to drive metabolic pumps and acts as a coenzyme in cells. This compound is also an important endogenous signaling molecule in immunity and inflammation.
- Provides metabolic energy for cellular processes.
- Acts as a coenzyme in various metabolic pathways.
- Functions as an endogenous signaling molecule in immunity and inflammation.
- Can activate the NLRP3 inflammasome.
- Induces secretion of IL-1β, KC and MIP-2 from BMDMs.
- Promotes neutrophil chemotaxis.
- Protects mice against bacterial infection in vivo.
Sigma Aldrich Fine Chemicals Biosciences Adenosine 13C10 5 triphosp25MG
Adenosine 13C10 5 triphosp25MG
Medchemexpress LLC Guanosine 5'-diphosphate-15N5 dilithium | 146-91-8 | 98.2% | 460.03 | 1 MG
Guanosine 5'-diphosphate-15N5 dilithium | 146-91-8 | 98.2% | 460.03 | 1 MG
Medchemexpress LLC Guanosine 5'-diphosphate sodium | 43139-22-6 | 99.9% | 465.18 | 100 MG
Guanosine 5'-diphosphate (GDP) sodium, 96% (HPLC), is a nucleoside diphosphate that activates the adenosine 5'-triphosphate-sensitive K+ channel. It functions as an iron mobilizer by forming a complex with hepcidin, thereby inhibiting the hepcidin-ferroportin (FPN) interaction and modulating the IL-6/stat-3 pathway. This compound can ameliorate Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4 and is suitable for AI research.
- Activates adenosine 5'-triphosphate-sensitive K+ channel.
- Functions as an iron mobilizer.
- Inhibits hepcidin-ferroportin interaction.
- Modulates the IL-6/stat-3 pathway.
- Ameliorates Turpentine-induced anemia of inflammation (AI) in mice when combined with FeSO4.
- Suitable for research applications.
Cambridge Isotope Laboratories Guanosine phosphoramidite (U-15N5 98%) CP 95% 50 mg
Guanosine phosphoramidite (U-15N5 98%) CP 95% 50 mg
Selleck Chemical LLC BRM/BRG1 ATP Inhibitor-1
BRM/BRG1 ATP Inhibitor-1 (Compound 14) is an orally active inhibitors of Brahma Homolog (BRM)/SMARCA2 (BRG1) with IC50s below 0 005 M
Teknova 100mM ATP, pH 7.5. 100mL, Sterile (Dry Ice Intl Required) 10 pack.
100mM ATP, pH 7.5. 100mL, Sterile (Dry Ice Intl Required) 10 pack.
Medchemexpress LLC Phosphoramidon disodium | 164204-38-0 | MFCD00077870 | 99.8% | 587.47 | C23H32N3Na2O10P | 10 MG
Phosphoramidon disodium is a microbial metabolite and metalloprotease inhibitor used as a research reagent to study metallopeptidases. It potently inhibits thermolysin (IC50 ≈ 0.4 μg/mL) and shows activity against endothelin-converting enzyme, neutral endopeptidase, and angiotensin-converting enzyme.
- High purity: 99.8% (typical, datasheet)
- White to off-white solid suitable for biochemical assays
- Soluble in water (≥140 mg/mL) and DMSO (100 mg/mL; sonication recommended)
- Storage: store sealed at 4°C; in solution store -80°C (up to 6 months) or -20°C (up to 1 month)
- Supplied in small research quantities, typically 10 mg
Medchemexpress LLC Adenosine 5'-diphosphoribose sodium | 68414-18-6 | MFCD00136017 | 99.5% | 581.30 g/mol | C15H22N5NaO14P2 | 25 MG
Adenosine 5′-diphosphoribose sodium is a high-purity nucleotide metabolite used in biochemical and cellular research to activate TRPM2 Ca2+-permeable channels and investigate nucleotide-mediated signaling. Supplied as a sodium salt in solid and solution formats, it includes solubility guidance for water and DMSO and storage recommendations for sealed, moisture-free conditions.
- High purity: 99.5% by HPLC.
- Soluble in water and DMSO with recommended concentrations for in vitro use.
- Available as solid (5-100 mg) and 10 mM solution in water.
- Used to activate TRPM2 channels and study nucleotide signaling pathways.
- Store sealed, away from moisture; follow recommended temperature guidelines.
Medchemexpress LLC 7-Methyl-guanosine-5'-triphosphate sodium (m7GTP sodium) | 50 MG
7-Methyl-guanosine-5'-triphosphate (m7GTP) sodium is a guanosine 5'-phosphate.
- Potent cap-dependent translation inhibitor.