Drug Standards
Selleck Chemical LLC S-Ruxolitinib (INCB018424) S2902-1g
S-Ruxolitinib is the chirality of INCB018424 which is the first potent selective JAK1/2 inhibitor to enter the clinic with IC50 of 3 3 nM/2 8 nM 130-fold selectivity for JAK1/2 versus JAK3 Phase 3
Apexbio Technology LLC Salbutamol Sulfate 51022-70-9 10mM (in 1mL H2O)
Salbutamol Sulfate (CAS 51022-70-9) is a short-acting selective 2-adrenergic receptor agonist widely employed in studies related to bronchial smooth muscle relaxation The compound exerts its pharmacological effects by selectively activating 2-adrenergic receptors leading to increased intracellular cyclic AMP and subsequent airway smooth muscle relaxation Research indicates that the R-enantiomer is primarily responsible for the observed physiological effects in guinea-pig skeletal muscle with minimal contribution from the S-enantiomer Salbutamol Sulfate is commonly utilized in biomedical research focused on asthma chronic obstructive pulmonary disease (COPD) and 2-receptor pharmacodynamics
Selleck Chemical LLC Bimatoprost 50mg 155206-00-1
Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Med Vet International Famciclovir Tablets (Famvir), 500mg, 30ct
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Famciclovir is a generic version of Famvir. It is used to treat infections caused by certain types of viruses and should be stored at room temperature away from light and moisture.
U.S. Pharmacopeia Diethyltoluamide Related Compound A | 2728-05-4 | MFCD00463008 | 25 mg
Diethyltoluamide Related Compound A | Mol Wt: 191.27 | 2728-05-4 | MFCD00463008 | 25 mg
Apexbio Technology LLC Cabozantinib malate (XL184) 1140909-48-3 25mg
Cabozantinib malate (XL184 CAS 1140909-48-3) is a small-molecule inhibitor targeting multiple receptor tyrosine kinases notably MET and VEGFR2 with reported IC50 values of 1 3 nM and 0 035 nM respectively It also inhibits additional kinases including RET FLT3 KIT AXL and TEK In cellular assays Cabozantinib shows inhibition of phosphorylation in kinases MET VEGFR2 KIT FLT3 and AXL Moreover Cabozantinib suppresses HMVEC cell-tube formation (IC50 6 7 nM) and attenuates hepatocyte growth factor-induced tumor cell invasion and migration This compound has demonstrated antiproliferative activity in several cancer cell lines supporting its application in oncology research environments
Medchemexpress LLC Elacridar | 143664-11-3 | 99.7% | C34H33N3O5 | 200 MG
Elacridar is an orally active inhibitor of P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP). It is utilized to study the impact of efflux transporters on agent distribution to the brain and in cancer research.
- Examines the influence of efflux transporters on agent distribution to the brain.
- Used in cancer research.
- Inhibits cell viability in 786-O cells.
- Affects P-glycoprotein and ABCG2 protein expression levels in MCF-7 and 786-O cell lines.
- Increases intracellular accumulation in MCF-7 and 786-O cells.
Selleck Chemical LLC Thioguanine 500mg 154-42-7
Thioguanine, a purine antimetabolite, inhibits DNMT1 activity through ubiquitin-targeted degradation, used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis) and organ transplant recipients. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Isosorbide S4204-50mg
Isosorbide(D-Isosorbide Dianhydro-D-glucitol) is a heterocyclic compound that is derived from glucose used as a diuretic
Sigma Aldrich Fine Chemicals Biosciences Ibandronate Related Compound A United States Pharmacopeia (USP) Reference Standard | 625120-81-2 | 25MG
Ibandronate Related Compound A United States Pharmacopeia (USP) Reference Standard | Mol Wt: 209.71 | 625120-81-2 | 25MG
Apexbio Technology LLC Flavopiridol hydrochloride 131740-09-5 100mg
Flavopiridol hydrochloride is a selective inhibitor of cyclin-dependent kinases (CDKs) specifically targeting CDK1 CDK2 CDK4 and CDK6 with reported IC50 values approximately 41 nM and CDK7 with an IC50 of about 300 nM Additionally it has been observed to inhibit EGFR and protein kinase A at micromolar concentrations By inhibiting CDK activity flavopiridol hydrochloride disrupts cell cycle progression inducing G1 phase arrest as demonstrated in breast cancer cell lines Furthermore its capacity to inhibit phosphorylation of Rb protein and suppress anti-apoptotic proteins such as Mcl-1 and XIAP facilitates apoptosis in lymphoma cell models Flavopiridol hydrochloride is utilized in preclinical studies of cell cycle regulation apoptosis signaling and cancer research including experiments using xenograft tumor models in mice
![Medchemexpress LLC 6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione | 2069937-25-1 | 10mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000266440.png-250.jpg)
Medchemexpress LLC 6-[(2-iminopyrrolidin-1-yl)methyl]-1H-pyrimidine-2,4-dione | 2069937-25-1 | 10mg
Tipiracil impurity 1 is an impurity of Tipiracil (HY-A0063A)
Apexbio Technology LLC Lenalidomide (CC-5013) 191732-72-6 50mg
Lenalidomide (CC-5013) a structural analog of thalidomide is a synthetic small-molecule agent exhibiting anti-tumor properties primarily through immune modulation and antiangiogenic activities Mechanistically lenalidomide promotes the activation of immune functions enhances expression of costimulatory molecules on leukemia lymphocytes and restores immunoglobulin synthesis thereby augmenting humoral immune responses Additionally it improves T cell interactions leading to restored immunological synapse formation and function Current research applications involve investigating lenalidomide s therapeutic potential in multiple myeloma myelodysplastic syndrome (MDS) chronic lymphocytic leukemia (CLL) and other lymphoproliferative disorders including non-Hodgkin lymphoma (NHL)
Medchemexpress LLC 2-bromo-4,5-dimethoxybenzyl alcohol | 54370-00-2 | MFCD02093896 | 98.0% | 247.09 | C9H11BrO3 | 1 G
Pinaverium impurity 1 (2-bromo-4,5-dimethoxybenzyl alcohol; CAS 54370-00-2) is an analytical impurity of the pharmaceutical active pinaverium. Supplied for research and analytical use, it is intended for impurity profiling, method development, and quality control. Consult the Certificate of Analysis for lot-specific purity and storage conditions.
- Analytical reference standard for impurity profiling.
- Chemical formula C9H11BrO3 and molecular weight 247.09.
- Suitable for method development and assay validation.
- Packaged in small quantities for laboratory use.
- For research use only; not for human or clinical applications.
