Drug Standards
Sigma Aldrich Fine Chemicals Biosciences Captopril impurity J European Pharmacopoeia (EP) Reference Standard | 64838-55-7 |
Captopril impurity J European Pharmacopoeia (EP) Reference Standard | Mol Wt: 259.32 | 64838-55-7 |
Sigma Aldrich Fine Chemicals Biosciences Lithium clavulanate European Pharmacopoeia (EP) Reference Standard | 61177-44-4 |
Lithium clavulanate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 205.09 | 61177-44-4 |
Sigma Aldrich Fine Chemicals Biosciences Pramipexole dihydrochloride monohydrate European Pharmacopoeia (EP) Reference Standard | 191217-81-9 |
Pramipexole dihydrochloride monohydrate European Pharmacopoeia (EP) Reference Standard | Mol Wt: 302.26 | 191217-81-9 |
Sigma Aldrich Fine Chemicals Biosciences Benazepril impurity A European Pharmacopoeia (EP) Reference Standard | 215447-89-5 |
Benazepril impurity A European Pharmacopoeia (EP) Reference Standard | Mol Wt: 460.95 | 215447-89-5 |
Medchemexpress LLC Flavopiridol hydrochloride (alvocidib hydrochloride) | 131740-09-5 | 99.7% | 438.30 | C21H21Cl2NO5 | 50 MG
Flavopiridol hydrochloride (alvocidib hydrochloride) is a research-grade, ATP-competitive inhibitor of cyclin-dependent kinases used in cell-cycle and signal-transduction studies. Supplied as a hydrochloride salt, it is formulated for biochemical and cellular assays and offers documented solubility and storage recommendations for reliable experimental use.
- Inhibits CDK1, CDK2, and CDK4 with reported IC50s of 30 nM, 170 nM, and 100 nM.
- High purity confirmed by HPLC suitable for research applications.
- Soluble in DMSO and water at ≥ 20 mg/mL for convenient stock preparation.
- Provided as a solid with recommended sealed, low-temperature storage to maintain stability.
- Available with solvent option to simplify assay setup.
Apexbio Technology LLC Gabapentin HCl 60142-95-2 10mM (in 1mL H2O)
Gabapentin HCl (CAS 60142-95-2) is a structurally related analog of gamma-aminobutyric acid (GABA) though it does not bind directly to GABA receptors Its primary mechanism involves binding to the 2 subunit of voltage-gated calcium channels in neuronal tissues resulting in decreased neurotransmitter release Originally investigated for antiepileptic properties gabapentin has been widely utilized in research exploring neuropathic pain modulation and neuronal excitability This molecule serves as a tool compound for studying calcium channel modulation and the pathophysiology of neurological disorders
Medchemexpress LLC Osimertinib dimesylate | 2070014-82-1 | 99.2% | C30H41N7O8S2 | 100 MG
Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor, effective against EGFRL858R and EGFRL858R/T790M with IC50s of 12 and 1 nM respectively. It demonstrates similar potency to early generation tyrosine kinase inhibitors (TKIs) in inhibiting EGFR phosphorylation in EGFR cells and potently inhibits phosphorylation in T790M mutant cell lines. This compound offers improved rat PK, reduced hERG affinity, and enhanced IGF1R margins. Its profile provides broader chemical diversity, showing comparable efficacy at low doses.
- Irreversible and mutant selective EGFR inhibitor
- Potently inhibits EGFR phosphorylation in T790M mutant cell lines
- Improved rat PK and reduced hERG affinity
- Broader chemical and profile diversity
- Comparable efficacy at low doses
Apexbio Technology LLC Fenoldopam 67227-56-9 10mM (in 1mL DMSO)
Fenoldopam is a small-molecule partial agonist targeting dopamine D1-like receptors It is designed to selectively activate these receptors thereby mediating peripheral vasodilation and modulating vascular resistance Fenoldopam exerts its biological activity primarily through D1-like receptor activation In in vitro studies Fenoldopam demonstrates partial agonist activity with an EC50 value of approximately 57 nM Additionally it exhibits inhibitory activity against 2-adrenoceptors with a reported Ki of 15 25 nM Based on these pharmacological properties Fenoldopam holds research potential in studies of cardiovascular regulation receptor pharmacodynamics and selective receptor ligand profiling
Apexbio Technology LLC Desogestrel 54024-22-5 25mg
Desogestrel (CAS 54024-22-5) is a synthetic progestogen derivative targeting the progesterone receptor It is designed to selectively activate this receptor thereby suppressing gonadotropin secretion and inhibiting ovarian follicle maturation and ovulation Desogestrel exerts its biological activity primarily through selective activation of progesterone receptors Based on its chemical structure desogestrel contains an alkyne functional group that enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with azide-containing molecules Based on these pharmacological properties desogestrel holds research potential in targeted drug modification probe labeling and pharmacological investigations as well as serving as an active ingredient in oral contraceptive formulations
Apexbio Technology LLC Detomidine HCl 90038-01-0 10mM (in 1mL DMSO)
Detomidine hydrochloride (CAS 90038-01-0) is a synthetic non-narcotic small molecule that functions as an agonist at the 2-adrenergic receptor By activating these presynaptic receptors detomidine hydrochloride inhibits norepinephrine release resulting in dose-dependent sedative and analgesic effects This compound is widely utilized in biomedical research to investigate 2-adrenergic signaling pathways study mechanisms of sedation and analgesia and model neuromodulatory processes involving noradrenergic neurotransmission Its pharmacological profile makes it valuable for exploring receptor-mediated modulation within both in vitro and in vivo experimental contexts
Apexbio Technology LLC Citalopram hydrobromide 59729-32-7 10mM (in 1mL DMSO)
Citalopram hydrobromide (CAS 59729-32-7) is a selective serotonin reuptake inhibitor (SSRI) that functions by specifically blocking the reuptake of 5-hydroxytryptamine (5-HT) at presynaptic neuronal membranes thereby increasing 5-HT concentrations in the synaptic cleft In vitro studies demonstrate that citalopram hydrobromide exhibits potent nanomolar-level inhibition of 5-HT reuptake in synaptosomal preparations as well as low nanomolar inhibition in rabbit platelet assays This compound is widely utilized in research exploring serotonergic signaling neurotransmission processes and experimental models of depression
Apexbio Technology LLC Enoxaparin 50mg
Enoxaparin (CAS 679809-58-6) is a low molecular weight heparin derivative that acts by potentiating the inhibitory activity of antithrombin III leading to the inhibition of coagulation factors such as thrombin (factor IIa) Through this mechanism Enoxaparin demonstrates anticoagulant properties Experimental studies indicate that it confers neuroprotection in rat hippocampus following traumatic brain injury via antioxidative and anti-inflammatory pathways Enoxaparin is widely used in research investigating deep vein thrombosis pulmonary embolism traumatic brain injury and thrombotic complications associated with COVID-19
Apexbio Technology LLC Famciclovir 104227-87-4 100mg
Famciclovir (104227-87-4) is an orally available small-molecule prodrug of penciclovir targeting viral DNA polymerase It is designed to enhance the bioavailability of penciclovir thereby improving inhibition of herpesvirus replication Famciclovir exerts its biological activity primarily through selective inhibition of herpes simplex virus (HSV) DNA polymerase by penciclovir which competes with natural nucleotides In cell-based assays famciclovir-generated penciclovir demonstrates potent antiviral activity with reported IC50 values ranging from 0 1 to 0 8 g/mL Based on these pharmacological properties famciclovir holds research potential in studies of HSV and varicella-zoster virus (VZV) infections