Ion Chromatography Standards
Apexbio Technology LLC Coenzyme Q0 605-94-7 1g
Coenzyme Q0 (CAS 605-94-7) is a quinone derivative originally derived from cinnamon extract It modulates multiple cellular pathways by inducing apoptosis and autophagy primarily through inhibition of the HER-2/AKT/mTOR signaling cascade Additionally Coenzyme Q0 regulates transcription factors such as NF B and AP-1 enhances Nrf2 stability and mitigates inflammation and oxidative stress Its anti-angiogenic properties are mediated via downregulation of the MMP-9/NF- B pathway and upregulation of HO-1 signaling Coenzyme Q0 is widely used in basic research and drug development targeting cancer inflammation and angiogenesis-related disorders
Apexbio Technology LLC Nafcillin Sodium 7177-50-6 1g
Nafcillin Sodium (7177-50-6) is a small-molecule inhibitor targeting -lactamase It is designed to reversibly inhibit -lactamase thereby preventing bacterial resistance mediated by hydrolysis of -lactam antibiotics Nafcillin Sodium exerts its biological activity primarily through reversible inhibition of -lactamase In in vitro studies Nafcillin Sodium demonstrates inhibitory activity with an IC50 value of approximately 33 mM Based on these pharmacological properties Nafcillin Sodium holds research potential in investigating -lactamase-mediated antibiotic resistance mechanisms evaluating therapeutic combination strategies and studying bacterial susceptibility profiles
Apexbio Technology LLC TBHQ 1948-33-0 1g
Tert-butylhydroquinone (TBHQ CAS 1948-33-0) is a synthetic aromatic compound structurally characterized by a phenylpropanoid framework TBHQ functions primarily as an antioxidant where it inhibits the peroxidation of lipids by scavenging free radicals and stabilizing cell membranes Beyond its established role in food preservation TBHQ is widely utilized in biomedical research to investigate oxidative stress responses and cellular defense mechanisms Its modulatory effects on signaling pathways such as Nrf2-mediated transcription underscore its value in studies related to redox biology and cytoprotection
Apexbio Technology LLC PDE5-IN-7 139756-21-1 1g
PDE5-IN-7 (CAS 139756-21-1) is a selective inhibitor of phosphodiesterase 5 (PDE5) functioning by impeding PDE5 enzymatic activity and thereby reducing the hydrolysis of cyclic guanosine monophosphate (cGMP) This results in elevated intracellular cGMP levels In biochemical assays PDE5-IN-7 demonstrates potent inhibition of PDE5 with an IC50 of approximately 5 nM while displaying significantly lower potency against PDE1 (IC50 300 nM) Due to its selectivity and potency PDE5-IN-7 is valuable for investigating cGMP-mediated signaling vasorelaxation mechanisms and pathways involved in cardiovascular physiology
Apexbio Technology LLC Adrenosterone 382-45-6 1g
Adrenosterone (CAS 382-45-6) is a small-molecule inhibitor targeting 11- -hydroxysteroid dehydrogenase 1 It is designed to competitively inhibit this enzyme thereby modulating steroid metabolism pathways Adrenosterone exerts its biological activity primarily through enzymatic inhibition In human cancer cell studies Adrenosterone demonstrates inhibitory activity on metastatic progression Based on these pharmacological properties Adrenosterone holds research potential in studying steroid metabolism androgen receptor interactions endocrine regulation mechanisms and hormone-dependent diseases
Apexbio Technology LLC Oxolinic acid 14698-29-4 1g
Oxolinic acid (CAS 14698-29-4) is a small-molecule inhibitor targeting bacterial DNA gyrase and the dopamine transporter It is designed to inhibit DNA gyrase thereby impairing bacterial DNA synthesis and to inhibit dopamine uptake affecting neurotransmitter regulation Oxolinic acid exerts its biological activity primarily through inhibition of DNA gyrase and dopamine uptake In in vitro studies oxolinic acid demonstrates dopamine uptake inhibition with an IC50 value of 4 3 M Based on these pharmacological properties oxolinic acid holds research potential in studies of bacterial DNA replication mechanisms and dopamine transporter interactions in neuropharmacological research
Apexbio Technology LLC WZ811 55778-02-4 1g
WZ811 (CAS 55778-02-4) is a small molecule antagonist targeting the CXC chemokine receptor 4 (CXCR4) Structurally composed of two aromatic amine groups WZ811 inhibits the binding of TN14003 to CXCR4 with an EC50 of 0 3 nM and disrupts stromal cell-derived factor 1 (SDF-1)-mediated CXCR4 signaling In cAMP assays WZ811 significantly attenuates SDF-1-induced cAMP responses and impedes SDF-1-driven Matrigel invasion (EC50 5 2 nM) Given CXCR4 s involvement in infection inflammation and various diseases WZ811 serves as a valuable tool for interrogating CXCR4-related biological processes and disease models and has been reported to display modest anti-HIV activity in cell cultures
Apexbio Technology LLC Amsacrine 51264-14-3 1g
Amsacrine (CAS 51264-14-3) also known as m-AMSA is a small-molecule inhibitor of DNA topoisomerase II It is widely used as an antineoplastic agent in biomedical research particularly for investigating the treatment of lymphomas and acute leukemias Amsacrine exhibits cytotoxic effects across various cancer cell lines with reported IC50 values of 190 2 27 4 ng/ml 46 1 3 9 ng/ml and 22 6 3 1 ng/ml in HT1376 RT112 and RT4 bladder cancer cells and 11 8 2 0 ng/ml 5 0 0 4 ng/ml and 11 7 1 5 ng/ml in the 833K Susa and GH testicular cancer cell lines respectively Testicular cancer cell lines display greater sensitivity to Amsacrine-induced inhibition than bladder cancer cell lines This compound is valuable for studying DNA damage mechanisms and the cellular response to topoisomerase II inhibition
Apexbio Technology LLC Risedronate 105462-24-6 1g
Risedronate (CAS 105462-24-6) is a small-molecule inhibitor targeting farnesyl pyrophosphate (FPP) synthase It is designed to inhibit this enzyme in the mevalonate pathway thereby reducing osteoclast prenylation and function Risedronate exerts its biological activity primarily through selective binding to hydroxyapatite surfaces in bone leading to decreased osteoclastic activity and suppressed bone resorption Based on these pharmacological properties Risedronate holds research potential in the study of osteoclast biology metabolic bone disorders osteoporosis and bone remodeling processes
Apexbio Technology LLC Chenodeoxycholic Acid 474-25-9 1g
Chenodeoxycholic Acid is a small-molecule agonist targeting the farnesoid X receptor (FXR) It is designed to selectively activate FXR thereby regulating critical signaling pathways involved in bile acid homeostasis lipid metabolism and cholesterol regulation Chenodeoxycholic Acid exerts its biological activity primarily through FXR-dependent modulation of transcriptional pathways Based on these pharmacological properties Chenodeoxycholic Acid holds research potential in the investigation of hepatic metabolism mechanisms cholesterol balance metabolic disorders and FXR-mediated gene expression in various physiological and pathological conditions
Apexbio Technology LLC Oxeladin Citrate 52432-72-1 1g
Oxeladin citrate (CAS 52432-72-1) is a small-molecule agonist targeting sigma-1 receptors It is designed to selectively activate sigma-1 receptors thereby modulating neural signaling pathways involved in cough reflex regulation neuroprotection pain perception and respiratory control Oxeladin citrate exerts its biological activity primarily through sigma-1 receptor agonism It exhibits an affinity (Ki) of approximately 25 nM for the sigma-1 receptor Based on these pharmacological properties Oxeladin citrate holds research potential in investigating cough suppression respiratory function and pathophysiological conditions associated with central nervous system pulmonary dysfunction and cerebrovascular disorders
Apexbio Technology LLC Mepiroxol 6968-72-5 1g
Mepiroxol is a small-molecule compound characterized by its ability to form specific interactions with target proteins It engages in salt bridge interactions with arginine residues (such as Arg-153 and Arg-74) and participates in hydrogen bonding via its hydroxyl group with protein residues like Asp-50 and Gly-96 supporting enhanced binding affinity Researchers utilize Mepiroxol for investigations into protein-ligand interaction mechanisms aiding structural biology analyses and guiding drug-design efforts
Apexbio Technology LLC Clomiphene citrate 50-41-9 1g
Clomiphene citrate (CAS 50-41-9) is a small-molecule modulator targeting estrogen receptors (ER) It is designed to selectively modulate ER-mediated signaling thereby influencing estrogen-dependent cellular pathways Clomiphene citrate exerts its biological activity primarily through competitive inhibition at estrogen receptors It demonstrates both antiestrogenic and estrogenic activities depending on tissue context Based on these pharmacological properties clomiphene citrate holds research potential in the investigation of estrogen receptor-mediated transcriptional regulation cellular proliferation and differentiation as well as hypothalamic-pituitary-gonadal axis regulation and ovarian follicular maturation in reproductive biology studies