Acetylides
eMolecules 2949-26-0 | NAPHTHYLENE-2-ACETYLENE | AstaTech | MFCD00870424 | 152.196 | C12H8 | 98.000 | C#Cc1ccc2ccccc2c1 | 5g | 112530615
NAPHTHYLENE-2-ACETYLENE | AstaTech | 2949-26-0 | MFCD00870424 | 152.196 | C12H8 | 98.000 | C#Cc1ccc2ccccc2c1 | 5g | 112530615
eMolecules 927-74-2 | 3-Butyn-1-ol | Oakwood Chemicals | MFCD00002955 | 70.091 | C4H6O | 98.000 | OCCC#C | 1g | 480108296
3-Butyn-1-ol | Oakwood Chemicals | 927-74-2 | MFCD00002955 | 70.091 | C4H6O | 98.000 | OCCC#C | 1g | 480108296
![Medchemexpress LLC Propanoic acid, 3-[2-[[2-(2-propyn-1-yloxy)ethyl]dithio]ethoxy]- | 1807503-85-0 | >95.0% | 264.36 g/mol | C10H16O4S2 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204167.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[[2-(2-propyn-1-yloxy)ethyl]dithio]ethoxy]- | 1807503-85-0 | >95.0% | 264.36 g/mol | C10H16O4S2 | 100 MG
Propargyl-PEG1-SS-PEG1-acid is a cleavable two-unit polyethylene glycol (PEG) linker containing a propargyl (alkyne) group and a disulfide bond, terminating in a carboxylic acid. It is intended for click-chemistry-enabled bioconjugation and as a reducible linker in antibody-drug conjugate synthesis.
- Cleavable disulfide linkage for reductive release.
- Alkyne handle compatible with copper-catalyzed azide-alkyne cycloaddition.
- Carboxylic acid terminus for amide coupling or further functionalization.
- Purity typically ≥95%.
- Available in multiple sizes, including 100 mg.
- Stable when stored under recommended temperatures.
Medchemexpress LLC Propargyl-PEG3-acid | 1347760-82-0 | 99.1% | 216.23 g/mol | C10H16O5 | 5 G
Propargyl-PEG3-acid is a PEG-based bifunctional linker bearing a terminal propargyl (alkyne) group and a carboxylic acid. It is used in bioconjugation and medicinal chemistry applications such as click chemistry and PROTAC or ADC linker construction.
- Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition
- Three-unit PEG spacer improves solubility and flexibility
- Carboxylic acid functionality enables standard coupling chemistries
- High purity (99.14%) and liquid form, colorless to light yellow
- Available in multiple sizes, including a 5 g package; recommended storage: -20°C for long-term stability
Medchemexpress LLC Propargyl-PEG8-NH2 | 1196732-52-1 | 98.0% | 10 G
Propargyl-PEG8-NH2 is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a non-cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs). This compound is a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Peg-based protac linker
- Non-cleavable adc linker
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Boc-propargylamine | 92136-39-5 | 99.5% | C8H13NO2 | 10 G
N-Boc-Propargylamine is a biochemical reagent used as a biological material or organic compound for life science-related research. It is a click chemistry reagent, containing an alkyne group, that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
- Used to prepare triazolobenzylidene-thiazolopyrimidines
- Acts as CDC25 phosphatase inhibitors
- Used for the synthesis of beta-glucan polysaccharide analogs
- Involved in the Pauson-Khand (PK) reaction to prepare 4,5-dissubstituted cyclopentenones
eMolecules 106-96-7 | Propargyl bromide | Broadpharm | MFCD00000241 | 118.961 | C3H3Br | 0.000 | BrCC#C | 500g | 795361322
Propargyl bromide | Broadpharm | 106-96-7 | MFCD00000241 | 118.961 | C3H3Br | 0.000 | BrCC#C | 500g | 795361322
eMolecules 874821-52-0 | 5-Chloro-2-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | MFCD11519357 | 226.580 | C8H6ClF3O2 | 95.000 | OCc1cc(Cl)ccc1OC(F)(F)F | 1g | 562461133
5-Chloro-2-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | 874821-52-0 | MFCD11519357 | 226.580 | C8H6ClF3O2 | 95.000 | OCc1cc(Cl)ccc1OC(F)(F)F | 1g | 562461133
Medchemexpress LLC Propargyl-PEG5-Br | 1287660-83-6 | 339.22 | 250 MG
Propargyl-PEG5-Br is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It also functions as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups. This linker is ideal for researchers developing novel protein degradation therapeutics.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC Boc-Propargylamine | 92136-39-5 | 99.5% | C8H13NO2 | 25 G
Boc-Propargylamine is a biochemical reagent suitable for use as a biological material or organic compound in life science research. It functions as a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules possessing Azide groups.
- Used to prepare triazolobenzylidene-thiazolopyrimidines, which act as CDC25 phosphatase inhibitors.
- Used for the synthesis of beta-glucan polysaccharide analogs.
- Involved in the Pauson-Kh reaction of norbornadiene and N-Boc-propargylamine to prepare 4,5-dissubstituted cyclopentenones.
![Medchemexpress LLC Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1428629-71-3 | 97.0% | 313.30 g/mol | C14H19NO7 | 250 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000203474.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1428629-71-3 | 97.0% | 313.30 g/mol | C14H19NO7 | 250 MG
Propargyl-PEG3-NHS ester is an amine-reactive N-hydroxysuccinimide (NHS) ester with a terminal propargyl alkyne and a three-unit PEG spacer. It is designed for bioconjugation and linker chemistry, enabling amide bond formation with primary amines and copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide partners.
- Amine-reactive NHS ester for stable amide bond formation.
- Terminal alkyne enables CuAAC click chemistry.
- Three-unit PEG spacer provides flexibility and solubility.
- Suitable for PROTAC and antibody-drug conjugate linker synthesis.
- High purity (97.0% by NMR) and molecular weight 313.30 g/mol.
=O | 1g | 562428509](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502154630.JPG-250.jpg)
eMolecules 2149598-58-1 | 3-Fluoro-2-(trifluoromethoxy)-6-nitroaniline | Apollo Scientific | MFCD30723447 | 240.114 | C7H4F4N2O3 | 95.000 | Nc1c(OC(F)(F)F)c(F)ccc1[N+]([O-])=O | 1g | 562428509
3-Fluoro-2-(trifluoromethoxy)-6-nitroaniline | Apollo Scientific | 2149598-58-1 | MFCD30723447 | 240.114 | C7H4F4N2O3 | 95.000 | Nc1c(OC(F)(F)F)c(F)ccc1[N+]([O-])=O | 1g | 562428509
eMolecules 4-Chloro-2-(trifluoromethoxy)-DL-phenylalanine | 1435806-19-1 | MFCD19687214 | 1g
Apollo Scientific | 4-Chloro-2-(trifluoromethoxy)-DL-phenylalanine | 1g | 562459894 | PC302857 | | 1435806-19-1 | MFCD19687214 | 283.630 | C10H9ClF3NO3
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Medchemexpress LLC Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]- | 7218-43-1 | 99.7% | 1 G
Propargyl-PEG2-OH is a PEG-based PROTAC linker. It functions as a click chemistry reagent, possessing an alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups. This compound can be utilized in the synthesis of Thalidomide-O-PEG2-propargyl.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Utilized in the synthesis of thalidomide-O-PEG2-propargyl
Medchemexpress LLC Propargyl-PEG6-NHS ester | 2093153-99-0 | 445.46 g/mol | C20H31NO10 | 100 MG
Propargyl-PEG6-NHS ester is an alkyne-terminated polyethylene glycol (PEG) linker bearing an N-hydroxysuccinimide (NHS) active ester used for click chemistry and bioconjugation. It reacts with azide-containing molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC) and with primary amines via NHS-mediated coupling, and is commonly used in linker synthesis for ADCs and PROTACs.
- Alkyne-terminated PEG linker suitable for click chemistry.
- NHS active ester for efficient conjugation to primary amines.
- PEG6 spacer provides solubility and flexibility in conjugates.
- Available in small-scale quantities for research applications.
- Recommended storage at -20°C; protect from moisture and light.