Acetylides
Medchemexpress LLC Propargyl-PEG4-CH2CH2-Boc | 1245823-50-0 | 360.44 g·mol⁻¹ | C18H32O7 | 100 MG
Propargyl-PEG4-CH2CH2-Boc is a PEG-based linker bearing a terminal propargyl (alkyne) group and a Boc-protected amine. It is used as a non-cleavable ADC linker, a PROTAC linker, and as a reagent for click chemistry (copper-catalyzed azide-alkyne cycloaddition).
- Contains a terminal alkyne suitable for copper-catalyzed azide-alkyne cycloaddition.
- Boc-protected amine enables orthogonal deprotection strategies.
- Applicable as a non-cleavable ADC linker or a PROTAC linker in conjugation workflows.
- Molecular weight 360.44 g·mol⁻¹; CAS 1245823-50-0.
- Store pure material at -20°C for long-term stability; in solvent store at -80°C for best stability.
Enzo Life Sciences R(-)-Deprenyl. HCl (100mg). CAS: 14611-52-0
Deprenyl inhibits apoptosis and displays neuroprotective effects in a variety of in vitro and in vivo systems. In vivo it rescues nigral dopaminergic neurons after systemic MPTP treatment. In vitro it rescues PC12 cells from apoptotic cell death induced by trophic withdrawal. The putative target responsible for the anti-apoptotic effects is glyceraldehyde-3-phosphate dehydrogenase. Deprenyl also inhibits monoamine oxidase-B, which is not involved in its anti-apoptotic mechanism. Parkinson’s disease therapeutic. Alternative name: Selegiline hydrochloride. Purity: ≥98% (HPLC). Solubility: Soluble in water. Long Term Storage: Ambient.
Medchemexpress LLC Propargyl-PEG8-acid | 2055014-94-1 | 98.0% | 436.49 | C20H36O10 | 250 MG
Propargyl-PEG8-acid is an alkyne-functionalized PEG8 linker used as a cleavable linker in PROTAC and antibody-drug conjugate synthesis. It functions as a click chemistry reagent (terminal alkyne) for copper-catalyzed azide-alkyne cycloaddition and is supplied with high purity for medicinal chemistry applications.
- Alkyne-terminated PEG8 linker suitable for CuAAC click reactions.
- Cleavable linker for PROTAC and antibody-drug conjugate (ADC) assembly.
- Molecular formula C20H36O10; molecular weight 436.49.
- High purity laboratory grade, suitable for synthesis.
- Available in multiple pack sizes including 250 mg.
Medchemexpress LLC 3-Butynyl p-toluenesulfonate | 23418-85-1 | MFCD00041687 | 98.7% | 224.28 g/mol | C11H12O3S | 10 G
An alkyne-bearing p-toluenesulfonate ester used as a click-chemistry reagent and cleavable linker for antibody-drug conjugate synthesis; it undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Reacts in copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Molecular formula C11H12O3S; molecular weight 224.28 g/mol.
- CAS number 23418-85-1.
- Purity typically 98.7%.
- Appearance colorless to light yellow liquid.
- Available in 1 g, 5 g, 10 g, and 50 g package sizes.
Medchemexpress LLC Bis-propargyl-PEG8 100mg | 1092554-87-4 | 446.53 | C22H38O9 | 100 MG
Bis-propargyl-PEG8 is a PEG-based linker bearing two terminal propargyl (alkyne) groups designed for click-chemistry conjugation. It provides a flexible PEG8 spacer for use in PROTAC synthesis and other bioconjugation workflows, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) between azide- and alkyne-functionalized partners.
- Contains two terminal alkyne groups for CuAAC click chemistry.
- Peg8 spacer improves solubility and provides flexible linker length.
- Suitable for synthesis of PROTACs and other bioconjugates.
- Available in laboratory-scale pack sizes for research use.
- Provided as a ready-to-use reagent for organic synthesis workflows.
Medchemexpress LLC Propargyl-PEG3-acid | 1347760-82-0 | 99.1% | 216.23 g/mol | C10H16O5 | 5 G
Propargyl-PEG3-acid is a PEG-based bifunctional linker bearing a terminal propargyl (alkyne) group and a carboxylic acid. It is used in bioconjugation and medicinal chemistry applications such as click chemistry and PROTAC or ADC linker construction.
- Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition
- Three-unit PEG spacer improves solubility and flexibility
- Carboxylic acid functionality enables standard coupling chemistries
- High purity (99.14%) and liquid form, colorless to light yellow
- Available in multiple sizes, including a 5 g package; recommended storage: -20°C for long-term stability
Medchemexpress LLC Propargyl-PEG8-NH2 | 1196732-52-1 | 98.0% | 10 G
Propargyl-PEG8-NH2 is a PEG-based PROTAC linker used in the synthesis of PROTACs. It is also a non-cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs). This compound is a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Peg-based protac linker
- Non-cleavable adc linker
- Click chemistry reagent
- Contains an alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc)
Medchemexpress LLC Boc-propargylamine | 92136-39-5 | 99.5% | C8H13NO2 | 10 G
N-Boc-Propargylamine is a biochemical reagent used as a biological material or organic compound for life science-related research. It is a click chemistry reagent, containing an alkyne group, that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
- Used to prepare triazolobenzylidene-thiazolopyrimidines
- Acts as CDC25 phosphatase inhibitors
- Used for the synthesis of beta-glucan polysaccharide analogs
- Involved in the Pauson-Khand (PK) reaction to prepare 4,5-dissubstituted cyclopentenones
eMolecules 874821-52-0 | 5-Chloro-2-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | MFCD11519357 | 226.580 | C8H6ClF3O2 | 95.000 | OCc1cc(Cl)ccc1OC(F)(F)F | 1g | 562461133
5-Chloro-2-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | 874821-52-0 | MFCD11519357 | 226.580 | C8H6ClF3O2 | 95.000 | OCc1cc(Cl)ccc1OC(F)(F)F | 1g | 562461133
Medchemexpress LLC Propargyl-PEG5-Br | 1287660-83-6 | 339.22 | 250 MG
Propargyl-PEG5-Br is a PEG-based PROTAC linker designed for the synthesis of PROTACs. It also functions as a click chemistry reagent, featuring an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups. This linker is ideal for researchers developing novel protein degradation therapeutics.
- PEG-based PROTAC linker
- Used in PROTAC synthesis
- Functions as a click chemistry reagent
- Contains an alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide groups
Medchemexpress LLC Propargyl-PEG6-NHS ester | 2093153-99-0 | 445.46 g/mol | C20H31NO10 | 100 MG
Propargyl-PEG6-NHS ester is an alkyne-terminated polyethylene glycol (PEG) linker bearing an N-hydroxysuccinimide (NHS) active ester used for click chemistry and bioconjugation. It reacts with azide-containing molecules via copper-catalyzed azide-alkyne cycloaddition (CuAAC) and with primary amines via NHS-mediated coupling, and is commonly used in linker synthesis for ADCs and PROTACs.
- Alkyne-terminated PEG linker suitable for click chemistry.
- NHS active ester for efficient conjugation to primary amines.
- PEG6 spacer provides solubility and flexibility in conjugates.
- Available in small-scale quantities for research applications.
- Recommended storage at -20°C; protect from moisture and light.
Aobchem 4-Phenyl-3-butyn-2-ol | ≥97% | CAS 5876-76-6 | C10H10O | 1g
4-Phenyl-3-butyn-2-ol | ≥97% | CAS 5876-76-6 | C10H10O | 1g
Medchemexpress LLC Bis-PEG1-C-PEG1-CH2COOH | 2358775-67-2 | 95.0% | 25 MG
Bis-PEG1-C-PEG1-CH2COOH, also known as PROTAC Linker 26, is a PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs, which are compounds designed to exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. PROTACs achieve this by connecting two different ligands, one for an E3 ubiquitin ligase and another for the target protein, via a linker.
- PEG-based PROTAC linker
- Useful in the synthesis of PROTACs
- Facilitates selective degradation of target proteins
- Purity of 95.0%
- Molecular weight of 350.40
- Chemical formula C16H30O8
- Appears as an off-white to yellow oil
- Soluble in DMSO up to 100 mg/mL
- Recommended storage at -20°C for pure form
eMolecules 1218790-89-6 | 2-Formyl-5-(trifluoromethoxy)phenylboronic acid | Combi-Blocks | MFCD10566600 | 233.940 | C8H6BF3O4 | 97.000 | OB(O)c1cc(OC(F)(F)F)ccc1C=O | 1g | 117526368
2-Formyl-5-(trifluoromethoxy)phenylboronic acid | Combi-Blocks | 1218790-89-6 | MFCD10566600 | 233.940 | C8H6BF3O4 | 97.000 | OB(O)c1cc(OC(F)(F)F)ccc1C=O | 1g | 117526368