Acetylides
Medchemexpress LLC Arecaidine propargyl ester hydrobromide | 116511-28-5 | MFCD00078566 | 99.5% | C10H14BrNO2 | 10MG
Arecaidine propargyl ester hydrobromide is a small-molecule M2 muscarinic acetylcholine receptor agonist supplied as the hydrobromide salt. It has been reported to modulate M2 receptor activity and to inhibit tumor cell proliferation in vitro. The compound is provided as a white to off-white solid for laboratory research applications and is characterized by a high-purity specification.
STA Pharmaceutical 2'-propargyl G(iBu) amidite | 200 mg | CAS 171486-61-6 | MDL MFCD28976150
2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 200 mg. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 15 mL HDPE
- Pack Size: 200 mg
- Net Weight: 0.2 g
- Gross Weight: 6.9 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C
Medchemexpress LLC Propargyl-PEG4-amine 5g | 1013921-36-2 | 5 G
Propargyl-PEG4-amine is an alkyne-terminated PEG4 linker with a primary amine, used in PROTAC linker assembly, click chemistry, and bioconjugation workflows. It enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) and amide bond formation for attaching payloads or linkers.
- Contains terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Primary amine enables amide coupling to activated carboxylic acids or NHS esters.
- Peg4 spacer provides flexibility and improved solubility in aqueous systems.
- Molecular weight 231.29 g/mol and formula C11H21NO4.
- High purity suitable for chemical biology and linker synthesis applications.
Medchemexpress LLC Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]-, 1-methanesulfonate | 943726-01-0 | 95.0% | 1 G
Propargyl-PEG2-MS is a PEG-based PROTAC linker primarily used in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting an E3 ubiquitin ligase ligand with a target protein ligand via a linker.
- PEG-based PROTAC linker
- Functions as a click chemistry reagent
- Contains an alkyne group for copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Appears as a colorless to light yellow liquid
eMolecules 106-96-7 | 3-Bromo-1-Propyne(80% wt.in toluene) | AA Blocks LLC | MFCD00000241 | 118.961 | C3H3Br | 0.000 | BrCC#C | 500g | 586018242
3-Bromo-1-Propyne(80% wt.in toluene) | AA Blocks LLC | 106-96-7 | MFCD00000241 | 118.961 | C3H3Br | 0.000 | BrCC#C | 500g | 586018242
eMolecules 1092460-86-0 | 5-Fluoro-2-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | MFCD11519336 | 210.128 | C8H6F4O2 | 95.000 | OCc1cc(F)ccc1OC(F)(F)F | 1g | 562454462
5-Fluoro-2-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | 1092460-86-0 | MFCD11519336 | 210.128 | C8H6F4O2 | 95.000 | OCc1cc(F)ccc1OC(F)(F)F | 1g | 562454462
Selleck Chemical LLC AZ 628 S2746-1g
AZ628 is a new pan-Raf inhibitor for BRAF BRAFV600E and c-Raf-1 with IC50 of 105 nM 34 nM and 29 nM in cell-free assays also inhibits VEGFR2 DDR2 Lyn Flt1 FMS etc AZ628 induces apoptosis
eMolecules 1261673-90-8 | 4-Chloro-2-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | MFCD18393819 | 226.580 | C8H6ClF3O2 | 98.000 | OCc1ccc(Cl)cc1OC(F)(F)F | 1g | 562456700
4-Chloro-2-(trifluoromethoxy)benzyl alcohol | Apollo Scientific | 1261673-90-8 | MFCD18393819 | 226.580 | C8H6ClF3O2 | 98.000 | OCc1ccc(Cl)cc1OC(F)(F)F | 1g | 562456700
Medchemexpress LLC Propargyl-PEG8-NHS ester | 2182601-74-5 | MFCD31536764 | 95.0% | 533.57 | C24H39NO12 | 50 MG
Propargyl-PEG8-NHS ester is an alkyne-terminated PEG8 N-hydroxysuccinimidyl (NHS) ester used as an activated linker for amine coupling and copper-catalyzed azide-alkyne cycloaddition (click chemistry).
- Provides an activated NHS ester for efficient amine coupling.
- Contains a terminal propargyl group for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- PEG8 spacer improves solubility and reduces steric hindrance.
- Suitable for linker and conjugation synthesis such as ADC and PROTAC linker construction.
- Viscous liquid physical form with recommended cold storage for stability.
