Acetylides
Medchemexpress LLC Propargyl-PEG7-NHS ester | 2093152-77-1 | MFCD29041936 | >95.0% | 489.51 g/mol | C22H35NO11 | 1 G
Propargyl-PEG7-NHS ester is an alkyne-functional PEG7 N-hydroxysuccinimide (NHS) ester used as a bifunctional linker for bioconjugation. It couples to primary amines via NHS chemistry and provides a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition, making it suitable for ADC, PROTAC, and general labeling applications.
- Alkyne-functional terminal enables click chemistry.
- NHS ester reacts with primary amines for covalent coupling.
- PEG7 spacer increases solubility and provides flexibility.
- Molecular weight about 489.51 g/mol and formula C22H35NO11.
- Typical applications include ADC linkers, PROTAC synthesis, and peptide or protein labeling.
eMolecules 96439-99-5 | 3-Bromo-2-ethynylpyridine | MFCD18256373 | 1g
Ambeed | 3-Bromo-2-ethynylpyridine | 1g | 600847246 | A758874 | 96439-99-5 | MFCD18256373 | 182.020 | C7H4BrN
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Medchemexpress LLC Propargyl-PEG7-NHS ester | 2093152-77-1 | MFCD29041936 | >95.0% | 489.51 g/mol | C22H35NO11 | 100 MG
Propargyl-PEG7-NHS ester is an alkyne-containing PEG7 NHS ester linker used for bioconjugation and chemical conjugation workflows. It is used as a cleavable ADC linker, a PROTAC linker, and as a click-chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Alkyne-functional NHS ester for CuAAC click chemistry.
- PEG7 spacer provides hydrophilicity and flexibility.
- Suitable for synthesis of PROTACs and antibody-drug conjugates.
- Amine-reactive NHS ester enables conjugation to lysine residues.
- Available in small research pack sizes (100 mg, 250 mg, 1 g).
Medchemexpress LLC VQW-765 | 669770-29-0 | MFCD28502153 | 99.6% | 294.39 g/mol | C19H22N2O | 10 MG
VQW-765 is an orally active, selective partial agonist of the α7 nicotinic acetylcholine receptor (α7-nAChR) developed for preclinical research into anxiety and related CNS disorders. Supplied as a pre-weighed 10 mg research reagent, it is intended for use in in vitro and in vivo studies and is not for human consumption.
- Selective α7 nicotinic acetylcholine receptor partial agonist.
- Orally active compound suitable for in vivo dosing.
- High chemical purity (approximately 99.6%).
- Supplied as a pre-weighed 10 mg quantity for dosing convenience.
- Appropriate for both in vitro and in vivo pharmacology studies.
- Research use only; not for human or clinical use.
Medchemexpress LLC Propargyl-PEG3-OCH2-Boc | 888010-02-4 | 302.36 | 50 MG
Propargyl-PEG3-OCH2-Boc is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. This compound is strictly for research use and is not intended for patient treatment.
- PEG-based PROTAC linker for PROTAC synthesis
- Click chemistry reagent with Alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Reacts with molecules containing Azide groups
- Chemical formula: C15H26O6
- Intended for research use only
eMolecules Propargyl-PEG6-alcohol | 1036204-60-0 | MFCD27635181 | 1g
Broadpharm | Propargyl-PEG6-alcohol | 1g | 229582392 | BP-22010 | 98.000 | 1036204-60-0 | MFCD27635181 | 276.329 | C13H24O6
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eMolecules 4-(Propargylaminocarbonyl)phenylboronic acid pinacol ester | 1218790-49-8 | MFCD11113041 | 1g
Combi-Blocks | 4-(Propargylaminocarbonyl)phenylboronic acid pinacol ester | 1g | 117546930 | PN-9139 | 96.000 | 1218790-49-8 | MFCD11113041 | 285.150 | C16H20BNO3
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Medchemexpress LLC 3-Butynyl p-toluenesulfonate | 23418-85-1 | MFCD00041687 | >97.0% | 224.28 g/mol | C11H12O3S | 5 G
Propargyl-tos (3-butynyl p-toluenesulfonate) is a propargyl-containing tosylate ester used as a cleavable linker and an alkynyl reagent for click chemistry, bioconjugation, and linker synthesis in medicinal chemistry. It is supplied as a purified solid for synthetic chemistry applications.
- Cleavable ADC linker and click chemistry reagent.
- Used in bioconjugation and linker synthesis.
- High purity (>97.0%) available for synthetic applications.
- Molecular weight 224.28 g/mol and formula C11H12O3S.
- Supplied in small pack sizes suitable for laboratory synthesis.
Medchemexpress LLC 2-((Benzo[d]thiazol-2-ylmethyl)thio)-4,5,6,7-tetrahydro-8H-cyclopenta[d]triazolo[1,5-a]pyrimidin-8 | 3112403-98-9 | 99.9% | 355.44 | 25 MG
WS-917 is a potent and orally active ABCB1 modulator that enhances ABCB1 ATPase activity. It significantly enhances the antitumor effect of paclitaxel when combined with an anti-PD-1 antibody, and also promotes CD8+ T-cell activation. This product is for research use only and has not been fully validated for medical applications.
- Potent and orally active ABCB1 modulator
- Enhances ABCB1 ATPase activity
- Significantly enhances antitumor effect of paclitaxel combined with anti-PD-1 antibody
- Promotes CD8+ T-cell activation
Sigma Aldrich Fine Chemicals Biosciences Cyclopropylacetylene Neat, 97% | 6746-94-7 | MFCD02181090 | 25G
Cyclopropylacetylene Neat, 97% | Purity: 97% | Mol Wt: 66.1 | 6746-94-7 | MFCD02181090 | 25G
STA PHARMACEUTICAL US LLC 2'-propargyl G(iBu) amidite | 1 g | CAS 171486-61-6 | MDL MFCD28976150
2'-propargyl G(iBu) amidite is a Amidite reagent (Subcategory: 2'-propargyl Series) sold by WuXi TIDES. Offered in 1 g. Store at -20 °C. SDS available for reference.
Specifications
- CAS: 171486-61-6
- MDL: MFCD28976150
- InChIKey: AGWGPRXHCUPJJO-VCGWOZLGSA-N
- Molecular Weight: 893.978761998
- Molecular Formula: C47H56N7O9P
- Purity: ≥95%
- Container Type: 60 mL Glass (Septum)
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 38.3 g
- Commodity Code: 29349990
- Country Of Origin: China
- IUPAC: (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(prop-2-yn-1-yloxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: CC(N(P(O[C@H]1[C@H]([C@@H](O[C@@H]1COC(C2=CC=C(C=C2)OC)(C3=CC=C(C=C3)OC)C4=CC=CC=C4)N5C(N=C(N6)NC(C(C)C)=O)=C(N=C5)C6=O)OCC#C)OCCC#N)C(C)C)C
Medchemexpress LLC Propargyl-PEG4-Br | 1308299-09-3 | 5 G
Propargyl-PEG4-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a non-cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs).
- Functions as a PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Acts as a non-cleavable ADC linker
- Utilized in the synthesis of antibody-drug conjugates (ADCs)
- Serves as a click chemistry reagent
- Contains an Alkyne group
- Undergoes copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Medchemexpress LLC Propargyl-peg8-oh | 1351556-81-4 | 250 MG
Propargyl-PEG8-OH is a PEG-based PROTAC linker that can be utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules that contain Azide groups.
- Utilized in the synthesis of protacs
- Functions as a click chemistry reagent
- Contains an alkyne group for CuAAC reactions
- Leverages the intracellular ubiquitin-proteasome system