Acetylides
Medchemexpress LLC Propargyl-PEG1-Boc | 488150-84-1 | 97.0% | 184.23 | 100 MG
Propargyl-PEG1-Boc is an alkyl/ether-based PROTAC linker, a click chemistry reagent, utilized in the synthesis of PROTACs. It contains an Alkyne group enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules possessing Azide groups.
- Used as a PROTAC linker for synthesizing PROTACs.
- Functions as a click chemistry reagent.
- Contains an Alkyne group for CuAAc reactions.
- Enables reactions with molecules possessing Azide groups.
- Supports the PROTAC mechanism of action, which involves the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Medchemexpress LLC N-(Propargyl-PEG4)-biocytin | 2055042-71-0 | 98.0% | C28H46N4O9S | 250 MG
N-(Propargyl-PEG4)-biocytin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It functions as a click chemistry reagent, featuring an Alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. PROTACs consist of two different ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other the protein of interest, utilizing the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Alkyne group
- Enables copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Supports targeted protein degradation
Medchemexpress LLC Bis-propargyl-PEG6 100mg | 400775-35-1 | 358.43 g·mol⁻¹ | C18H30O7 | 100 MG
Bis-propargyl-PEG6 is a polyethylene glycol (PEG) linker bearing two terminal propargyl (alkyne) groups separated by a six-unit PEG spacer. It supplies clickable alkyne handles for copper-catalyzed azide-alkyne cycloaddition (CuAAC) and is used to build bifunctional molecules such as PROTACs, polymer-linked multimers, and other bioconjugates. Molecular formula C18H30O7; MW 358.43 g·mol⁻1; CAS 400775-35-1.
- Provides two terminal alkyne handles for click chemistry.
- Six-unit PEG spacer improves aqueous solubility and flexibility.
- Well suited for PROTAC linker construction and bioconjugation.
- Compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Typically supplied as a 100 MG package; store at -20 °C for stability.
Chem-Impex International, Inc. 4-Ethynylaniline | MFCD00168824 | 5G
4-Ethynylaniline, MFCD00168824, 5G
eMolecules 3-Fluoro-2-(trifluoromethoxy)-6-nitroaniline | 2149598-58-1 | MFCD30723447 | 1g
Apollo Scientific | 3-Fluoro-2-(trifluoromethoxy)-6-nitroaniline | 1g | 562428509 | PC508018 | | 2149598-58-1 | MFCD30723447 | 240.114 | C7H4F4N2O3
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Medchemexpress LLC Ws-917 | 10 MG
WS-917 is a small-molecule research compound characterized as a potent, orally active ABCB1 (P-glycoprotein) modulator. It enhances ABCB1 ATPase activity, promotes CD8+ T-cell activation, and has been shown to potentiate the antitumor effect of paclitaxel when combined with anti-PD-1 therapy. Intended for research use; follow appropriate storage and handling.
- Potent, orally active ABCB1 modulator.
- Enhances ABCB1 ATPase activity.
- Promotes CD8+ T-cell activation.
- Shown to enhance paclitaxel antitumor effect in combination with anti-PD-1 therapy.
- Molecular formula C16H13N5OS2; molecular weight 355.44 g/mol.
- Recommended storage: 4°C under nitrogen; in solution store at -80°C (up to 6 months) or -20°C (up to 1 month) under nitrogen.
Medchemexpress LLC Propargyl-PEG5-amine | 1589522-46-2 | MFCD27977505 | 98.9% | 275.34 g/mol | C13H25NO5 | 250 MG
Propargyl-PEG5-amine is a PEG-based linker reagent used as an alkyne functional handle for click chemistry and as a non-cleavable linker in ADC and PROTAC synthesis.
- PEG-based alkyne linker for conjugation and click chemistry.
- Non-cleavable linker suitable for ADC and PROTAC applications.
- Provides an alkyne handle for copper-catalyzed azide-alkyne cycloaddition.
- High purity and fully characterized by LCMS, HNMR, and RP-HPLC.
- Available in multiple pack sizes, including 250 MG.
- Colorless to light yellow liquid with a density of 1.049 g/cm3.
Medchemexpress LLC Propargyl-PEG1-bromide | 18668-74-1 | MFCD00099299 | 98.0% | 163.01 | C5H7BrO | 1 G
Propargyl-PEG1-bromide is an alkyne-functionalized short polyethylene glycol (PEG) linker bearing a terminal bromide. It is used in bioconjugation and medicinal chemistry to introduce a clickable propargyl handle while providing a reactive leaving group for further substitution, enabling efficient incorporation of a short PEG spacer into synthetic linkers and small-molecule constructs.
- Provides an alkyne (propargyl) handle for click chemistry.
- Contains a terminal bromide for nucleophilic substitution reactions.
- Short PEG1 spacer improves solubility and minimizes steric hindrance.
- Molecular weight ~163.01 g/mol for predictable stoichiometry.
- Suitable for linker synthesis, bioconjugation, and small-molecule modification.
eMolecules 3-Chloro-5-(trifluoromethoxy)bromobenzene | 1417567-41-9 | MFCD11856023 | 1g
Apollo Scientific | 3-Chloro-5-(trifluoromethoxy)bromobenzene | 1g | 562453196 | PC50439 | 97.000 | 1417567-41-9 | MFCD11856023 | 275.450 | C7H3BrClF3O
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eMolecules 4-Chloro-2-(trifluoromethoxy)benzyl alcohol | 1261673-90-8 | MFCD18393819 | 1g
Apollo Scientific | 4-Chloro-2-(trifluoromethoxy)benzyl alcohol | 1g | 562456700 | PC302320 | 98.000 | 1261673-90-8 | MFCD18393819 | 226.580 | C8H6ClF3O2
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Medchemexpress LLC 3-(2-((2-(prop-2-yn-1-yloxy)ethyl)disulfanyl)ethoxy)propanoic acid | 1807503-85-0 | MFCD28505557 | >95.0% | 264.36 | C10H16O4S2 | 25 MG
Propargyl-PEG1-SS-PEG1-acid is a cleavable two-unit polyethylene glycol (PEG) linker containing a propargyl (alkyne) reactive handle and a disulfide (SS) cleavable bond. It is designed for click-chemistry conjugation and for constructing cleavable antibody-drug conjugates and other bioconjugates.
- Cleavable disulfide linker enabling reductive release of payload.
- Propargyl alkyne handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Two-unit PEG spacer to improve solubility and reduce steric hindrance.
- High purity (>95.0%) as determined by NMR.
- Suitable for ADC linker synthesis and general bioconjugation applications.
Medchemexpress LLC Fmoc-amino-PEG3-CH2COOH | 139338-72-0 | 99.8% | 429.46 | 500 MG
Fmoc-amino-PEG3-CH2COOH is a PEG-based PROTAC linker. It is used in the synthesis of PROTACs, which are molecules containing two different ligands connected by a linker. One ligand is for an E3 ubiquitin ligase and the other is for the target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
Medchemexpress LLC Propargyl-PEG8-NH2 | 1196732-52-1 | ≥98.0% | 407.50 g/mol | C19H37NO8 | 250 MG
Propargyl-PEG8-NH2 is a PEG-based linker reagent containing a terminal propargyl (alkyne) group and a terminal primary amine for conjugation. It is used in proteolysis targeting chimera (PROTAC) and antibody-drug conjugate (ADC) linker synthesis, and as a click chemistry reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Contains a terminal propargyl alkyne group for copper-catalyzed azide-alkyne cycloaddition.
- Provides a terminal primary amine (NH2) for amide coupling or conjugation.
- High purity suitable for synthetic applications and linker assembly.
- Available in small-scale quantities suitable for research use.
- Stable when stored under recommended conditions to preserve reactivity.
Medchemexpress LLC Propargyl-PEG3-bromide | 203740-63-0 | 97.7% | 251.12 | 250 MG
Propargyl-PEG3-bromide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent due to its Alkyne group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent with Alkyne group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Reacts with molecules containing Azide groups