Lignans and related compounds
Apexbio Technology LLC Etoposide, 33419-42-0, MFCD00869325, 100 mg
MF: C29H32O13, MW: 588.56, Solubility: 29.45mg/mL in DMSO. Etoposide (VP-16) is the first agent recognized as a topoisomerase II inhibitor of anticancer drug with IC50 of 59.2 uM.
Sigma Aldrich Fine Chemicals Biosciences Etoposide | 33419-42-0 | MFCD00869325 | 25 mg
Etoposide | Purity: 98.0-105.0% | Mol Wt: 588.56 | 33419-42-0 | MFCD00869325 | 25 mg
Medchemexpress LLC N-demethyl ivabradine-d6 hydrochloride | 98.0% | 497.06 g/mol | C26H29D6ClN2O5 | 5 MG
N-Demethyl Ivabradine-d6 hydrochloride is the deuterium-labeled N-demethyl metabolite of ivabradine supplied as the hydrochloride salt. It is provided as a solid powder intended for use as an analytical standard or tracer in quantitative NMR, GC-MS, or LC-MS applications.
- Deuterium-labeled (d6) analogue for use as an internal standard.
- High purity (98.0%).
- Provided as a hydrochloride salt in solid powder form.
- Available in small analytical pack sizes suitable for assay development.
- Storage stability: powder -20°C (3 years) or 4°C (2 years).
- Suitable as a tracer and internal standard for quantitative analysis by NMR, GC-MS, and LC-MS.
Apexbio Technology LLC Etoposide 33419-42-0 10mM (in 1mL DMSO)
Etoposide (VP-16) is a topoisomerase II inhibitor widely used in biomedical research to study mechanisms of DNA damage and cancer therapy It forms a stabilized complex with DNA and topoisomerase II preventing the enzyme-mediated religation of cleaved DNA strands Resulting DNA double-strand breaks lead to apoptosis particularly in rapidly dividing cancer cells Reported IC50 values vary across cell lines such as 59 2 M for topoisomerase II inhibition 30 16 M in HepG2 and 0 051 M for MOLT-3 indicating differential cytotoxic responses to etoposide in various cancer cell models
Medchemexpress LLC Etoposide phosphate | 117091-64-2 | 99.4% | 668.54 | 1 ML
Etoposide phosphate is a water-soluble derivative and prodrug of etoposide, functioning as a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor. It prevents re-ligation of DNA strands and induces cell cycle arrest, apoptosis, and autophagy, making it suitable for various research applications.
- Potent anti-cancer chemotherapy agent
- Selective topoisomerase II inhibitor
- Prevents re-ligation of DNA strands
- Induces cell cycle arrest, apoptosis, and autophagy
- Water-soluble derivative and probable prodrug of etoposide
- Inhibits HCT116 cell growth in a dose-dependent manner
Medchemexpress LLC Etoposide | 33419-42-0 | 588.56 | 1 ML
Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent that inhibits topoisomerase II, thereby stopping DNA replication and inducing cell cycle arrest, apoptosis, and autophagy.
- Acts as an anti-cancer chemotherapy agent
- Inhibits topoisomerase II activity
- Stops DNA replication
- Induces cell cycle arrest, apoptosis, and autophagy
- Soluble in DMSO for in vitro studies
- Applicable for cancer and infection research