Hydrochlorides
Apexbio Technology LLC RS 127445 HCl 199864-87-4 10mM (in 1mL DMSO)
RS 127445 HCl (CAS 199864-87-4) is a small-molecule antagonist targeting the serotonin 5-HT2B receptor a member of the G-protein coupled receptor family It is designed to selectively block 5-HT2B receptor activity thereby modulating intracellular signaling pathways such as calcium elevation and inositol phosphate production RS 127445 HCl exerts its biological activity primarily through selective antagonism of the 5-HT2B receptor In isolated tissue preparations such as rat stomach fundus and jugular vein RS 127445 HCl inhibits serotonin-induced contraction Based on these pharmacological properties RS 127445 HCl holds research potential in studies of 5-HT2B receptor function and related physiological processes
Chem-Impex International, Inc. 3-Butyn-1-amine hydrochloride | 88211-50-1 | MFCD06658391 | 1G
3-Butyn-1-amine hydrochloride, 88211-50-1, MFCD06658391, 1G
Medchemexpress LLC Zk756326 dihydrochloride | 1780259-94-0 | MFCD09038571 | 99.9% | 429.38 | C21H30Cl2N2O3 | 1 ML
ZK756326 dihydrochloride is a small-molecule, nonpeptide agonist of the CC chemokine receptor CCR8 supplied for research use in biochemical and cell-based assays. It is available as a 10 mM solution in DMSO (1 mL) and as crystalline solids, and is provided with analytical documentation to verify identity and purity.
- Nonpeptide CCR8 agonist suitable for receptor pharmacology studies.
- Offered as 10 mM solution in DMSO (1 mL) and in multiple solid quantities for assay flexibility.
- High purity (99.87%) supporting reproducible experimental results.
- Comes with analytical documentation: COA, HNMR, LCMS, and SDS.
- Storage guidance for stability: sealed storage; in solvent, -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC GR 55562 dihydrochloride | 159533-25-2 | 99.0% | 448.39 | C23H27Cl2N3O2 | 10 MG
GR 55562 dihydrochloride is a research-grade small molecule that acts as a selective 5-HT1B (serotonin) receptor antagonist for preclinical and in vitro studies probing 5-HT1B-mediated signaling and neurological disease mechanisms.
- Selective 5-HT1B receptor antagonist.
- High purity (99.0%).
- Solid form suitable for analytical and biological assays.
- Store under nitrogen, away from moisture; solvent storage -80°C (6 months) or -20°C (1 month).
- Available in 5 mg and 10 mg pack sizes.
Medchemexpress LLC GSK-LSD1 dihydrochloride | 2102933-95-7 | 99.5% | 289.24 | C14H22Cl2N2 | 10 MG
GSK-LSD1 dihydrochloride is a potent, selective, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1/KDM1A) with an IC50 of 16 nM. Provided as a solid for research use, the compound has been used in cellular studies to modulate gene expression, induce autophagy markers, and inhibit proliferation in various cancer cell lines. Handle and store according to safety data sheet recommendations.
Medchemexpress LLC GSK-LSD1 dihydrochloride | 2102933-95-7 | 99.5% | 289.24 g·mol⁻1 | C14H22Cl2N2 | 50 MG
This dihydrochloride salt is a potent, selective, and irreversible inhibitor of lysine-specific demethylase 1 (LSD1), used as a research probe for epigenetic regulation and metabolic studies. It exhibits an IC50 of 16 nM and is supplied with high reported purity.
- Potent LSD1 inhibition with IC50 of 16 nM.
- High purity (≈99.5%).
- Supplied as a dihydrochloride salt in solid and DMSO solution formats.
- Suitable for epigenetic and metabolic research applications.
- Available in small research pack sizes including 50 MG.
Medchemexpress LLC ZK756326 dihydrochloride | 1780259-94-0 | MFCD09038571 | 99.9% | 429.38 g/mol | C21H30Cl2N2O3 | 25 MG
ZK756326 dihydrochloride is a small-molecule, nonpeptide agonist of the CC chemokine receptor CCR8 supplied as the dihydrochloride salt for research use only. It is intended for in vitro pharmacology and preclinical studies where modulation of CCR8 signaling is required, and is provided with a defined formula, molecular weight, and high purity.
- Selective CCR8 agonist for receptor pharmacology studies.
- High purity suitable for analytical and biological assays (99.87%).
- Well-defined chemical identity with molecular formula and weight.
- Available in small pack sizes for laboratory research.
- For research use only; not for human or veterinary applications.
Medchemexpress LLC RX 801077 (hydrochloride) | 89196-95-2 | MFCD00672666 | 99.8% | 222.6708 | C11H11ClN2O | 10 MG
RX 801077 hydrochloride is a selective imidazoline I2 receptor (I2R) agonist provided for research use as a solid or as a 10 mM solution in DMSO. It is produced with high purity for pharmacological studies, including investigations of neuroprotection and anti-inflammatory mechanisms.
- Selective imidazoline I2 receptor agonist with reported Ki ≈ 70 nM.
- High purity, 99.8% as supplied.
- Available as solid and as a 10 mM solution in DMSO.
- Suitable for pharmacology, neuroprotection, and inflammation research.
- Store at 4°C; in solvent store at -80°C (6 months) or -20°C (1 month).
- Soluble in DMSO for stock solution preparation.
Medchemexpress LLC SKF89976A hydrochloride | 85375-15-1 | MFCD01321071 | 98.7% | 371.90 g/mol | C22H26ClNO2 | 1 ML
SKF89976A hydrochloride is the hydrochloride salt of SKF89976A, a selective GABA transporter 1 (GAT-1) inhibitor used in neuroscience and pharmacology research to probe GABA uptake and transporter function. The compound is supplied in solid form and as ready-to-use 10 mM solutions in DMSO, and is accompanied by SDS, data sheet, and certificate of analysis documentation.
- Selective inhibitor of GABA transporter 1 (GAT-1) used to study GABA uptake.
- Documented IC50 values for GAT-1, GAT-2, and GAT-3 in CHO cells.
- Available as solid and 10 mM solution in DMSO for ready use.
- High reported purity suitable for biochemical assays.
- Accompanied by SDS, data sheet, and COA for handling and quality assurance.
eMolecules 21987-29-1 | 4,4-DIFLUOROPIPERIDINE | AstaTech | MFCD03094281 | 121.131 | C5H9F2N | 95.000 | FC1(F)CCNCC1 | 5g | 261434923
4,4-DIFLUOROPIPERIDINE | AstaTech | 21987-29-1 | MFCD03094281 | 121.131 | C5H9F2N | 95.000 | FC1(F)CCNCC1 | 5g | 261434923
Medchemexpress LLC Benzenepropanoic acid, ß-(aminomethyl)-4-chloro-, hydrochloride (1:1) | 28311-31-1 | 99.8% | C10H13Cl2NO2 | 1 ML
Baclofen hydrochloride is a lipophilic derivative of γ-aminobutyric acid (GABA) and an orally active, selective metabotropic GABAB receptor (GABABR) agonist. It mimics the action of GABA, producing slow presynaptic inhibition through the GABAB receptor. This compound exhibits high blood-brain barrier penetrance, making it suitable for muscle spasticity research.
- Orally active, selective GABAB receptor agonist.
- Mimics GABA action for slow presynaptic inhibition.
- Exhibits high blood-brain barrier penetrance.
- Increases cell viability in huntingtin-expressing striatal cells.
- Enhances chymotrypsin-like proteasome activity.
- Ameliorates motor deficits in Huntington's disease animal models.
- Reduces neuronal intranuclear inclusions in animal models.
Medchemexpress LLC MRT68921 dihydrochloride | 2080306-21-2 | 99.7% | 507.50 g·mol^-1 | C25H36Cl2N6O | 1 MG
MRT68921 dihydrochloride is a potent dual NUAK1/ULK1 kinase inhibitor used in cancer and autophagy research. It inhibits ULK1 and ULK2 at low nanomolar concentrations, disrupts autophagy, and promotes apoptosis; the compound is supplied as a solid with documented solubility and storage recommendations for research use.
- Inhibits ULK1 and ULK2 at low nanomolar potency.
- Blocks cellular autophagy and promotes apoptosis.
- High reported purity suitable for biochemical assays.
- Soluble in water and DMSO with specified preparation conditions.
- Stable when stored sealed at recommended temperatures.
- Supplied in small solid package sizes for research use.
Apexbio Technology LLC VU 0361737 1161205-04-4 10mg
VU 0361737 (CAS 1161205-04-4) is a selective brain-penetrant positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4) It demonstrates high selectivity for mGluR4 over other mGluR subtypes with EC50 values of 240 nM for human and 110 nM for rat mGluR4 and shows minimal to no activity at mGluR1 mGluR2 mGluR3 mGluR6 and mGluR7 while exhibiting weak activity at mGluR5 and mGluR8 VU 0361737 crosses the blood-brain barrier and achieves significant brain exposure (brain plasma ratio of 4 1) with a short half-life (T1/2 20 min) following administration in rats This compound is utilized in studies exploring the modulation of basal ganglia neurotransmission and the pathophysiology of Parkinson s disease
![Medchemexpress LLC 1,1′,1′′,1′′′-[1,4-Piperazinediylbis(2,1-ethanediylnitrilo)]tetrakis[2-dodecanol] | 1265904-26-4 | 98.0% | 909.54 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000437399-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1,1′,1′′,1′′′-[1,4-Piperazinediylbis(2,1-ethanediylnitrilo)]tetrakis[2-dodecanol] | 1265904-26-4 | 98.0% | 909.54 | 10 MG
1,1′,1′′,1′′′-[1,4-Piperazinediylbis(2,1-ethanediylnitrilo)]tetrakis[2-dodecanol] is a lipid/lipidoid for the preparation of lipid-based or lipidoid nanoparticles. This product is for research use only and not sold to patients.
- Used in preparation of lipid-based or lipidoid nanoparticles.
- Appearance as a solid, light yellow to orange.
- Recommended storage for powder is -20°C for 3 years, 4°C for 2 years.
- Recommended storage for in solvent is -80°C for 6 months, -20°C for 1 month.
- Soluble in DMSO (25 mg/mL), requiring sonication.