Hydrochlorides
Medchemexpress LLC 2-iminothiolane hydrochloride | 4781-83-3 | MFCD00039013 | 99.9% | 137.63 g/mol | C4H8ClNS | 50 MG
2-Iminothiolane hydrochloride is a thiolating reagent that introduces sulfhydryl (-SH) groups into primary amines of proteins, peptides, and oligosaccharides for bioconjugation and cross-linking. Supplied as a white to off-white solid, it is intended for research use and should be stored sealed and away from moisture.
- High purity suitable for biochemical applications
- Efficient thiolation of primary amines under mild conditions
- Useful for protein and peptide modification and cross-linking
- Solid form easy to weigh and dissolve for reactions
- Stable when stored sealed and protected from moisture
Selleck Chemical LLC Terbinafine-50mg
Terbinafine (SF 86-327,TDT 067) is used to treat infections caused by a fungus. It works by killing the fungus or preventing its growth.
Medchemexpress LLC N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-nitrobenzamide | 890764-36-0 | MFCD12546140 | 99.6% | 384.39 g/mol | C22H16N4O3 | 25 MG
VU-29 (N-(1,3-diphenyl-1H-pyrazol-5-yl)-4-nitrobenzamide, CAS 890764-36-0) is a research small molecule that acts as a positive allosteric modulator of the metabotropic glutamate receptor 5 (mGlu5). Supplied as a high-purity solid, it is intended for use in in vitro and in vivo pharmacology and neuroscience research.
- Acts as a positive allosteric modulator of mGlu5 receptor.
- High purity suitable for research applications.
- Solid form for convenient handling and storage.
- Available in small mass packages for preclinical studies.
- Characterized by standard chemical identifiers for traceability.
Medchemexpress LLC Queuine dihydrochloride | 86496-18-6 | 350.20 | 50 MG
Queuine dihydrochloride is a selective substrate for tRNA guanine transglycosylase (TGT), incorporated into eukaryotic tRNA to promote modification. Its deficiency enhances aerobic glycolysis, inhibits oxidative phosphorylation, and promotes Warburg metabolism. It is useful for autoimmune diseases and cancer metabolic regulation and is for research use only.
- Selective substrate for tRNA guanine transglycosylase.
- Promotes tRNA modification in eukaryotic cells.
- Impacts mitochondrial function and Warburg metabolism.
- Deficiency linked to enhanced glycolysis and inhibited oxidative phosphorylation.
- Potential for autoimmune disease and cancer metabolic research.
- Reduces lactate dehydrogenase activity and lactate production.
- Natural TGT substrate, replacing guanine (G34) in tRNA.
Medchemexpress LLC VU-1545 | 890764-63-3 | 99.0% | 402.38 | 25 MG
VU-1545 is a potent metabotropic glutamate receptor 5 (mGluR5) positive allosteric modulator (PAM) with a Ki of 156 nM and an EC50 of 9.6 nM. It promotes AKT activation, efficiently doing so at concentrations as low as 0.1 and 1.0 μM. Studies have shown that VU-1545 at 10 and 100 μM promotes Akt phosphorylation. This compound is used for research purposes and is not intended for patient use.
- Potent mGluR5 positive allosteric modulator
- Ki of 156 nM for mGluR5
- EC50 of 9.6 nM for mGluR5
- Promotes AKT activation in neuronal cells
- Efficiently promotes Akt phosphorylation at 10.0 μM and 100.0 μM
Medchemexpress LLC VU 0357121 | 433967-28-3 | C17H17F2NO2 | 100 MG
VU 0357121 is a positive and highly selective mGlu5R allosteric modulator (PAM) with an EC50 of 33 nM. It is inactive or very weakly antagonizing at other mGlu receptor subtypes. It enhances glutamate sensitivity of mGlu5, likely due to an interaction at a site on the receptor distinct from the MPEP binding site, and does not possess mGlu5 NAM activity. It is for research use only.
- Enhances glutamate sensitivity of mGlu5
- Does not bind at the MPEP allosteric site of mGlu5
- A809V/rmGlu5 mutation inhibited the ability to shift the glutamate concentration response curve
- Response is not altered by the F585I/rmGlu5 mutation
Medchemexpress LLC ZK756326 dihydrochloride | 1780259-94-0 | 99.9% | 429.38 g/mol | C21H30Cl2N2O3 | 100 MG
ZK756326 dihydrochloride is a selective, non-peptide agonist of the CC chemokine receptor CCR8 supplied as the dihydrochloride salt for research use. The compound is provided as a high-purity solid intended for pharmacology and receptor biology studies, including in vitro receptor activation and mechanism-of-action experiments.
- High purity suitable for research assays.
- Selective agonist activity at CCR8 for receptor pharmacology.
- Supplied as a stable dihydrochloride salt for handling and formulation.
- Appropriate for in vitro signaling and binding studies.
- Store sealed and away from moisture to preserve stability.
Medchemexpress LLC Zacopride hydrochloride | 101303-98-4 | MFCD04971977 | 99.7% | 346.25 | C15H21Cl2N3O2 | 1 ML
Zacopride hydrochloride is a research-grade 5-HT3 receptor antagonist supplied as either a 10 mM solution in DMSO or as solid material for pharmacological and analytical studies. It has defined purity and physicochemical properties suitable for in vitro and in vivo protocols. Intended for research use only.
- High purity (99.69%).
- Concentration: 10 mM solution, 1 mL vial in DMSO.
- Also available as solid in multiple masses (5-100 mg; larger sizes by quote).
- Molecular weight 346.25; formula C15H21Cl2N3O2.
- CAS number 101303-98-4.
- Recommended solvent: DMSO; in vivo formulation suggestions provided.
- For research use only; not for human or clinical use.
Medchemexpress LLC PB28 dihydrochloride | 172907-03-8 | 99.6% | 443.49 | 10 MG
PB28 dihydrochloride is a high-affinity and selective sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM, also acting as a σ1 antagonist with a Ki of 0.38 nM. This cyclohexylpiperazine derivative inhibits electrically evoked twitch in guinea pig bladder and ileum, and can modulate SARS-CoV-2-human protein-protein interaction. It induces caspase-independent apoptosis and exhibits antitumor activity. This product is for research use only.
- High-affinity and selective sigma 2 (σ2) receptor agonist
- Sigma 1 antagonist
- Inhibits electrically evoked twitch in guinea pig bladder and ileum
- Modulates SARS-CoV-2-human protein-protein interaction
- Induces caspase-independent apoptosis
- Exhibits antitumor activity
Medchemexpress LLC Bepridil hydrochloride | 68099-86-5 | 99.98% | 403.00 | 1MG
Bepridil hydrochloride (CERM 1978) is a calcium channel blocker with antianginal activity. It is intended for research use only. In vivo, it reduces heart rate and mean arterial pressure, decreases mean coronary vascular resistance, and increases stroke volume in rats.
- Functions as a calcium channel blocker
- Possesses antianginal activity
- Reduces heart rate and mean arterial pressure
- Decreases mean coronary vascular resistance
- Increases stroke volume
- For research applications only
Medchemexpress LLC L-733060 hydrochloride | 148687-76-7 | 99.9% | 439.82 | 1 MG
L-733060 hydrochloride is a selective neurokinin-1 (NK-1) receptor antagonist. It primarily regulates pain transmission and neural plasticity by blocking the binding of Substance P to the NK-1 receptor. It blocks the promoting effect of Substance P on long-term potentiation (LTP) in the hippocampus and reverses orofacial hyperalgesia induced by experimental occlusal interference (EOI) in rats. Additionally, it inhibits neurogenic plasma extravasation and acts as an anti-tumor agent, making it suitable for studying chronic orofacial pain.
- Selective neurokinin-1 (NK-1) receptor antagonist
- Regulates pain transmission and neural plasticity
- Blocks Substance P binding to NK-1 receptor
- Reverses orofacial hyperalgesia
- Inhibits neurogenic plasma extravasation
- Acts as an anti-tumor agent
- Suitable for studying chronic orofacial pain
Medchemexpress LLC Vu 0255035 | 1135243-19-4 | 99.8% | 432.52 | C18H20N6O3S2 | 5 MG
VU 0255035 is a selective M1 muscarinic receptor antagonist used as a research tool to probe M1-mediated signaling and synaptic responses in neuronal preparations. It is supplied as a solid with high purity and is characterized by its molecular formula and weight; handle under recommended storage conditions for best stability.
- Selective M1 muscarinic receptor antagonist with demonstrated neuronal activity.
- High purity: 99.8%.
- Molecular weight 432.52; formula C18H20N6O3S2.
- Available in small research quantities, such as 5 mg.
- Supplied as a solid; store at 4°C and protect from light (in solvent: -80°C for long-term storage).
- Suitable as a pharmacological probe for electrophysiology and signaling assays.
Medchemexpress LLC N-(1,3-diphenylpyrazol-5-yl)-4-nitrobenzamide | 890764-36-0 | MFCD12546140 | 99.6% | 384.39 g/mol | C22H16N4O3 | 5 MG
VU-29 is a research small molecule that acts as a positive allosteric modulator of the metabotropic glutamate 5 (mGlu5) receptor. It potentiates mGlu5 signaling with high potency and selectivity, and is supplied for laboratory research in solid or solution formats.
- Positive allosteric modulator of mGlu5 with high potency (EC50 ≈ 9 nM).
- Selective for mGlu5 versus other metabotropic glutamate receptors.
- Reported high purity suitable for biochemical and cellular assays.
- Available as small solid quantities or as 10 mM solutions in DMSO for convenience.
- Chemical formula C22H16N4O3; molecular weight 384.39 g/mol.
Medchemexpress LLC A 438079 hydrochloride | 899431-18-6 | C13H10Cl3N5 | 50 MG
A 438079 hydrochloride is a potent and selective P2X7 receptor antagonist with a pIC50 of 6.9. It is intended for research use only and not sold to patients. This compound is a white to off-white solid with 99.99% purity.
- Potent and selective P2X7 receptor antagonist
- pIC50 of 6.9
- For research use only
- High purity (99.99%)
- White to off-white solid
- Reduces noxious and innocuous evoked activity in neuropathic rats
- Raises withdrawal thresholds in SNL and CCI models
- Reduces seizure severity and neuronal death in the hippocampus
- Prevents depletion of striatal DA stores
- Reduces nociceptive behaviour scores
Medchemexpress LLC Efaroxan hydrochloride | 89197-00-2 | 99.80% | 25 MG
Efaroxan hydrochloride is a potent, selective, and orally active α2-adrenoceptor antagonist, demonstrating antidiabetic activity. It also acts as a selective I1-Imidazoline receptor antagonist. This compound can be utilized in research related to cardiovascular disease.
- Potent, selective, and orally active α2-adrenoceptor antagonist.
- Possesses antidiabetic activity.
- Selective I1-Imidazoline receptor antagonist.
- Applicable for research in cardiovascular disease.
- Binds to I1-imidazoline and α2-adrenergic receptors with Kᵢ values of 0.15 nM and 5.6 nM, respectively, in bovine rostral ventrolateral medulla membranes.
- Increases plasma insulin levels in conscious fed and fasted rats without significantly affecting plasma glucose levels.