Hydrochlorides
Medchemexpress LLC DPTN (dihydrochloride) | 325767-87-1 | C22H20Cl2N4OS | 50 MG
DPTN dihydrochloride is a potent and selective antagonist for human, mouse, and rat A3 adenosine receptors. It exhibits Ki values of 1.65 nM for human A3AR, 9.61 nM for mouse A3AR, and 8.53 nM for rat A3AR. While it is weaker at mouse and rat A3AR compared with human A3AR, it also shows reduced selectivity (approximately 20-fold) versus the A2B adenosine receptor.
- Potent and selective A3 adenosine receptor antagonist
- Effective in human, mouse, and rat models
- Solid, light yellow to yellow appearance
- Stable under recommended storage conditions
Medchemexpress LLC DPTN dihydrochloride | 325767-87-1 | C22H20Cl2N4OS | 5 MG
DPTN dihydrochloride is a potent and selective human, mouse, and rat A3AR antagonist. It exhibits Ki values of 1.65 nM for human A3AR, 9.61 nM for mouse A3AR, and 8.53 nM for rat A3AR. This product is for research use only.
- Potent and selective A3AR antagonist
- High purity (98.47%)
- Solid appearance
- Light yellow to yellow color
- Store at -20°C, sealed, away from moisture
- Shipped at room temperature in continental US
Medchemexpress LLC PXS-6302 hydrochloride | 2584947-79-3 | C10H11ClF3NO2S | 50 MG
PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor known for its good skin penetrability, ability to reduce collagen deposition, and significant improvement of scar appearance. This compound is intended for research use only.
- Irreversible lysyl oxidase inhibitor
- Exhibits IC50s for Bovine LOX (3.7 μM), rh LOXL1 (3.4 μM), rh LOXL2 (0.4 μM), rh LOXL3 (1.5 μM), and rh LOXL4 (0.3 μM)
- Reduces collagen deposition and cross-linking in murine models of injury and fibrosis with topical application
- Significantly improves scar appearance in porcine injury models without reducing tissue strength
- Inhibits LOX and reduces crosslinking in porcine models of excisional and burn injury
Medchemexpress LLC SKF-96365 hydrochlor 10mM 1mL
SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca2 entry (SOCE) inhibitor SKF-96365 hydrochloride significantly inhibits hERG hKCNQ1/hKCNE1 hKir2 1 and hKv4 3 current and significantly prolongs the QTc interval in isolated guinea pig hearts SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells1]2]
Matrix Scientific 3-PYRIDYLACETIC ACID HYDROC-5G
3-Pyridylacetic acid hydrochloride, 98%; 5g,C7H8ClNO2, MFCD00012819, mw 173.60, [6419-36-9]
Medchemexpress LLC Tirofiban (hydrochloride monohydrate) | 150915-40-5 | 99.9% | 495.07 | 5 MG
Tirofiban hydrochloride monohydrate is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. It induces proliferation and migration on endothelial cells by inducing production of VEGF. Tirofiban hydrochloride monohydrate can significantly reduce myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area.
- Selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist
- Inhibits fibrinogen binding to the receptor
- Possesses antithrombotic activity
- Induces proliferation and migration on endothelial cells
- Significantly reduces myocardial no-reflow
- Alleviates myocardial microvascular structural and endothelial dysfunction
Medchemexpress LLC 3-Pyridylacetic acid hydrochloride | 6419-36-9 | 173.60 | 1 ML
3-Pyridylacetic acid hydrochloride is a high homolog of nicotinic acid and a decomposition product of nicotine (and other tobacco alkaloids). It can be used to synthesize anti-inflammatory agents or as a precursor for the preparation of herbicides.
- Used to synthesize anti-inflammatory agents
- Precursor for the preparation of herbicides
Medchemexpress LLC EG01377 dihydrochloride | 2749438-61-5 | 99.0% | 659.60 | 1 ML
EG01377 dihydrochloride is a potent, bioavailable, and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. It exhibits antiangiogenic, antimigratory, and antitumor effects.
- Inhibits vascular endothelial growth factor A (VEGF-A) stimulated tyrosine phosphorylation of VEGF-R2/KDR.
- Reduces HUVEC cell migration in response to VEGFA.
- Can delay VEGF-induced wound closure.
- Reduces network area, length, and branching points.
- Reduces VEGF-induced angiogenesis.
- Reduces A375P (malignant melanoma) spheroid outgrowth in combination with VEGFA.
- Blocks the production of transforming growth factor beta (TGFβ) by Nrp1+ regulatory T-cell SMAD3/AKT (Tregs) in the presence of tumor cell-derived factors.
- Exhibits an encouraging half-life sufficient to sustain once per day dosing in mice.
Medchemexpress LLC Tirofiban (hydrochloride monohydrate) | 150915-40-5 | MFCD07368623 | 99.9% | 495.07 g/mol | C22H39ClN2O6S | 10 MG
Tirofiban hydrochloride monohydrate is the hydrochloride monohydrate salt of tirofiban, a selective and reversible platelet integrin (Gp IIb/IIIa) antagonist supplied for research and analytical applications. It inhibits fibrinogen binding to the Gp IIb/IIIa receptor and is provided as a high-purity solid suitable for in vitro studies.
- Selective, reversible Gp IIb/IIIa antagonist suitable for platelet research.
- Inhibits fibrinogen binding to the Gp IIb/IIIa receptor.
- High purity (≈99.9%) for reproducible experimental results.
- Available in small laboratory quantities for analytical and preparative use.
- Supplied as a stable hydrochloride monohydrate salt for consistent handling.
Medchemexpress LLC AZD5582 dihydrochloride | 1883545-51-4 | 99.8% | 1088.21 | 1 ML
AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs). It binds to the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50s of 15 nM, 21 nM, and 15 nM, respectively, and induces apoptosis. It inhibits cell viability in cooperation with IFNγ or viral double-stranded RNA (dsRNA) in H1975 NSCLC cells. It also downregulates cIAP-1, activates RIPK1 (upstream regulator of caspase-8), and triggers the activation of extrinsic (caspase-8) and intrinsic (caspase-9) apoptosis pathways, leading to the cleavage of caspase-3 and caspase-7.
- Antagonist of inhibitor of apoptosis proteins (IAPs).
- Binds to BIR3 domains of cIAP1, cIAP2, and XIAP.
- Induces apoptosis.
- Inhibits cell viability in NSCLC cells.
- Downregulates cIAP-1 and activates RIPK1.
- Triggers extrinsic and intrinsic apoptosis pathways.
Medchemexpress LLC PB28 dihydrochloride | 172907-03-8 | CB4497464 | 99.6% | 443.49 | 25 MG
PB28 dihydrochloride is a cyclohexylpiperazine derivative, functioning as a high-affinity sigma 2 (σ2) receptor agonist with a Ki of 0.68 nM and a σ1 antagonist with a Ki of 0.38 nM. It demonstrates lower affinity for other receptors. This compound inhibits electrically evoked twitch in guinea pig bladder and ileum with EC50 values of 2.62 μM and 3.96 μM, respectively. It can modulate SARS-CoV-2-human protein-protein interaction, induces caspase-independent apoptosis, and exhibits antitumor activity.
- Accumulates in the G0-G1 phase for MCF7 and MCF7 ADR cells.
- Inhibits cell growth in MCF7 and MCF7 ADR cells.
- Induces apoptosis via a caspase-independent pathway.
- Reduces P-gp expression in MCF7 and MCF7 ADR cells.
- Displays antiproliferative and cytotoxic effects in C6 rat glioma and SK-N-SH human neuroblastoma cell lines.
- Inhibits tumor growth in Panc02 tumor burden mice.
Medchemexpress LLC 1-(2-Hydroxy-4,6-dimethoxyphenyl)-4-(piperazin-1-yl)butan-1-one dihydrochloride | 99.9% | 381.29 | 100 MG
Y13g dihydrochloride is a potent inhibitor of both acetylcholinesterase (AChE) and interleukin-6 (IL-6), which are significant targets in Alzheimer's Disease progression. This compound has been shown to reverse STZ-induced memory deficits and demonstrate histopathology similar to normal animal models. It is intended for research use only.
- Potent inhibitor of AChE and IL-6
- Reverses STZ-induced memory deficit
- Shows histopathology similar to normal animals
- Suitable for neurological disease research
Medchemexpress LLC EG01377 dihydrochloride | 2749438-61-5 | 99.0% | 659.60 | 25 MG
EG01377 dihydrochloride is a potent, bioavailable, and selective inhibitor of neuropilin-1 (NRP1), with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. It exhibits antiangiogenic, antimigratory, and antitumor effects by inhibiting vascular endothelial growth factor A (VEGF-A) stimulated tyrosine phosphorylation of VEGF-R2/KDR.
- Inhibits VEGF-A stimulated tyrosine phosphorylation of VEGF-R2/KDR.
- Reduces HUVEC cell migration and delays VEGF-induced wound closure.
- Reduces network area, length, branching points, and VEGF-induced angiogenesis.
- Combines with VEGFA to reduce A375P (malignant melanoma) spheroid outgrowth.
- Blocks TGFβ production by Nrp1+ regulatory T-cell SMAD3/AKT (Tregs).
- Exhibits a half-life of 4.29 h in mice, supporting once-daily dosing.
Medchemexpress LLC Terbinafine | 91161-71-6 | 99.96% | 291.43 | 1 ML
Terbinafine (TDT 067) is an orally active and potent antifungal agent. It functions as a potent non-competitive inhibitor of squalene epoxidase from Candida and exhibits antibacterial activity against certain Gram-positive and Gram-negative bacteria. This compound is also a click chemistry reagent, containing an Alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Orally active antifungal agent
- Potent non-competitive inhibitor of squalene epoxidase
- Exhibits antibacterial activity
- Functions as a click chemistry reagent
- Contains an alkyne group for CuAAc reactions
Medchemexpress LLC Kari 201 hydrochloride | 2376132-24-8 | 320.86 | 5 MG
KARI 201 hydrochloride is a selective, brain penetrant pan-competitive acid sphingomyelinase (ASM) inhibitor with an IC50 of 338.3 nM. It also acts as a ghrelin receptor agonist.
- Selective, brain penetrant pan-competitive acid sphingomyelinase (ASM) inhibitor
- Ghrelin receptor agonist
- Improves neuropathological features of Alzheimer's disease