Hydrochlorides
Medchemexpress LLC AMG-548 dihydrochloride | 2518299-32-4 | 99.9% | 534.48 | 10 MG
AMG-548 dihydrochloride is an orally active and selective p38α inhibitor with a Ki of 0.5 nM. It exhibits slight selectivity over p38β (Ki=36 nM) and a greater than 1000-fold selectivity against p38γ and p38δ. This compound is highly potent in inhibiting whole blood LPS-stimulated TNFα (IC50=3 nM) and also inhibits Wnt signaling by directly targeting Casein kinase 1 isoforms δ and ε.
- Selective p38α inhibitor (Ki=0.5 nM).
- Slightly selective over p38β (Ki=36 nM).
- Greater than 1000-fold selective against p38γ and p38δ.
- Potent inhibition of whole blood LPS stimulated TNFα (IC50=3 nM).
- Inhibits Wnt signaling by directly inhibiting Casein kinase 1 isoforms δ and ε.
Selleck Chemical LLC VU 0364439
VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with EC50 of 19 8 nM
Cayman Chemical 1Deoxynojirimycin hydrochlor
An inhibitor of α-glucosidase I and II (IC50s = ~2 µM for both); inhibits virus spread in HIV-infected lymphocyte cultures at 0.4 mM
Medchemexpress LLC SB 206553 hydrochloride | 1197334-04-5 | 99.4% | 328.80 g/mol | C17H17ClN4O | 25 MG
SB 206553 hydrochloride is a research compound that selectively antagonizes 5-HT2B and 5-HT2C serotonin receptors and is used in pharmacology and neuroscience studies to probe serotonergic signaling.
- Selective 5-HT2B/5-HT2C receptor antagonist/inverse agonist
- High purity suitable for research applications
- Solid, light yellow to yellow appearance for easy handling
- Stable when stored sealed and protected from moisture at -20°C
- Available in small milligram quantities for preclinical studies
Medchemexpress LLC TP0427736 hydrochloride | 2459963-17-6 | 99.2% | 334.85 | C14H11ClN4S2 | 100 MG
TP0427736 hydrochloride is a research-grade small-molecule inhibitor of the TGF-β type I receptor kinase (ALK5) used for biochemical and cell-based studies. It potently inhibits ALK5 kinase activity and reduces Smad2/3 phosphorylation in cellular assays, making it suitable for research on TGF-β/Smad signaling and related applications.
- Potent ALK5 inhibition, IC50 = 2.72 nM.
- Cellular activity: inhibits Smad2/3 phosphorylation in A549 cells, IC50 = 8.68 nM.
- High reported purity (99.22%).
- Supplied as the hydrochloride salt; available in research pack sizes including 100 mg.
- Molecular weight 334.85 g·mol-1; formula C14H11ClN4S2.
Medchemexpress LLC JMV 2959 hydrochloride | 2448414-54-6 | 545.08 | 10 MG
JMV 2959 hydrochloride is a potent growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist. It demonstrates an IC50 of 32±3 nM in LLC-PK1 cells and a dissociation constant (Kb) of 19±6 nM. This compound does not induce intracellular calcium mobilization on its own.
- Antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a)
- IC50 of 32±3 nM in LLC-PK1 cells
- Dissociation constant (Kb) of 19±6 nM
- Does not induce intracellular calcium mobilization
- Attenuates phencyclidine (PCP)-induced deficits in prepulse inhibition in vivo
eMolecules 98338-26-2 | 4-(BROMOMETHYL)-1-METHYLPIPERIDINE HBR | MFCD16618478 | 1g
AstaTech | 4-(BROMOMETHYL)-1-METHYLPIPERIDINE HBR | 1g | 222806229 | 84194 | 95.000 | 98338-26-2 | MFCD16618478 | 273.012 | C7H15Br2N
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Medchemexpress LLC Adl-5859 hydrochloride | 850173-95-4 | 99.7% | C24H29ClN2O3 | 10MG
ADL-5859 hydrochloride is the hydrochloride salt of a selective, orally active delta-opioid receptor agonist used as a research tool in pain pharmacology. It is supplied as a white to off-white solid with high purity and characterized potency in binding and functional assays.
- Selective delta (δ) opioid receptor agonist with low-nanomolar affinity.
- High purity (~99.7%) suitable for in vitro and in vivo studies.
- Documented potency: Ki ≈ 0.84 nM, EC50 ≈ 20 nM.
- Known off-target profile: hERG IC50 ≈ 78 μM, CYP2D6 IC50 ≈ 43 μM.
- Supplied in small lot sizes convenient for preclinical research.
Selleck Chemical LLC A-438079 HCl 100mg 899431-18-6
A-438079 HCl is a potent, and selective P2X7 receptor antagonist with pIC50 of 6.9. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Sigma Aldrich Fine Chemicals Biosciences o-Phenylenediamine dihydrochloride tablet, 2 mg substrate per tablet | 615-28-1 | MFCD00012966 | 50TAB
o-Phenylenediamine dihydrochloride tablet, 2 mg substrate per tablet | Mol Wt: 181.06 | 615-28-1 | MFCD00012966 | 50TAB
Medchemexpress LLC Ly 2389575 hydrochloride | 885104-09-6 | MFCD28133385 | 99.9% | 438.58 g/mol | C15H16BrCl3N4 | 100 MG
LY2389575 hydrochloride is a selective, noncompetitive negative allosteric modulator (NAM) of the metabotropic glutamate receptor 3 (mGlu3) supplied as the hydrochloride salt for research use. It is provided as a solid for in vitro and preclinical studies, including investigations of amyloid-β toxicity.
- Selective noncompetitive mGlu3 negative allosteric modulator.
- Supplied as hydrochloride salt in solid form, white to light yellow.
- High purity: 99.9%.
- Molecular formula C15H16BrCl3N4; molecular weight 438.58 g/mol.
- Available in multiple pack sizes and as a DMSO solution for convenience.
- Recommended storage: powder -20°C (long term) or 4°C (short term); in solvent -80°C.
Medchemexpress LLC 4-Hydroxytryptamine 1mg | 55206-11-6 | 387.41 | C14H21N5O6S | 1 MG
4-Hydroxytryptamine creatinine sulfate is the creatinine sulfate salt of 4-hydroxytryptamine (serotonin). It is a tryptamine derivative used as a research reagent and acts as a neurotransmitter agonist; reported activities include inhibition of [3H] norepinephrine uptake and modulation of norepinephrine release in animal studies.
- High purity: 97.9% (assay).
- Solid powder form, suitable for analytical and biological studies.
- Molecular weight 387.41 g·mol⁻¹.
- Chemical formula C14H21N5O6S.
- Provided in milligram-scale pack sizes for research use.
- Documentation available: COA, SDS, and elemental analysis report.
![Medchemexpress LLC N-[3-oxo-3-(4-pyridin-4-ylpiperazin-1-yl)propyl]-2,1,3-benzothiadiazole-4-sulfonamide | 1135243-19-4 | MFCD18086889 | 99.8% | 432.52 g·mol⁻¹ | C18H20N6O3S2 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000241985.png-250.jpg)
Medchemexpress LLC N-[3-oxo-3-(4-pyridin-4-ylpiperazin-1-yl)propyl]-2,1,3-benzothiadiazole-4-sulfonamide | 1135243-19-4 | MFCD18086889 | 99.8% | 432.52 g·mol⁻¹ | C18H20N6O3S2 | 50 MG
VU 0255035 is a selective, brain-penetrant muscarinic M1 receptor antagonist used as a research tool in neuroscience and pharmacology. It acts as a competitive M1 antagonist with demonstrated in vitro and in vivo activity, including reduction of cholinergic-induced neuronal depolarization and efficacy in seizure models. The compound is supplied as a well-characterized, high-purity small molecule for laboratory use.
- Selective muscarinic M1 receptor antagonist
- Brain-penetrant small molecule suitable for in vivo studies
- Demonstrated activity in electrophysiology and seizure models
- High purity suitable for pharmacology experiments
- Available in multiple laboratory-friendly package sizes
eMolecules 30796-90-8 | 2-Methylazepane Hydrochloride | 250mg
Ambeed | 222-Trimethylacetamide | 10g | 552727992 | A420019 | 754-10-9 | MFCD00008011 | 101.149 | C5H11NO
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AdipoGen Tirofiban
Chemical. CAS 144494-65-5. Formula C22H36N2O5S. MW 440.6. Synthetic Synthetic non-peptide selective glycoprotein GP IIb/IIIa receptor antagonist/inhibitor. Anticoagulant, specifically, an anti-platelet aggregation inhibitor.