Hydrochlorides
Medchemexpress LLC Dopamine (hydrochloride) | 62-31-7 | MFCD00012898 | 99.8% | 100 MG
Dopamine hydrochloride is a catecholamine neurotransmitter produced in the brain's substantia nigra, ventral tegmental area, and hypothalamus. It plays important roles in the brain and body. This compound acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
- Catecholamine neurotransmitter
- Produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain
- Plays several important roles in the brain and body
- Acts through D2 dopamine receptors
- Induces endocytosis of VEGFR2
- Critical for promoting angiogenesis
Medchemexpress LLC Amiloride hydrochloride dihydrate | 17440-83-4 | MFCD00211292 | 99.9% | 1 ML
Amiloride hydrochloride dihydrate is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). It also acts as a blocker of polycystin-2 (PC2; TRPP2) channel.
- Inhibits epithelial sodium channel (ENaC)
- Inhibits urokinase-type plasminogen activator receptor (uTPA)
- Blocks polycystin-2 (PC2; TRPP2) channel
Medchemexpress LLC PNU-22394 hydrochloride | 15923-42-9 | 98.8% | 236.74 g/mol | C13H17ClN2 | 5 MG
PNU-22394 hydrochloride is a research-grade small-molecule agonist of serotonin (5-HT) receptors, showing selectivity for 5-HT2C and activity at 5-HT2A. Supplied as a hydrochloride salt, it is intended for in vitro pharmacology and receptor signaling studies.
- Selective agonist at 5-HT2C with Ki = 6.1 nM.
- Also active at 5-HT2A (Ki = 10 nM).
- Assay-dependent EC50: 5-HT2C 7.7 nM (Fluo-4/Ca2+) and 0.12 μM (IP-One); 5-HT2A 23 nM (Fluo-4/Ca2+) and 0.21 μM (IP-One).
- Molecular formula C13H17ClN2; molecular weight 236.74 g/mol.
- High chemical purity (98.8%).
- Available in small milligram quantities for laboratory research.
Medchemexpress LLC Y-33075 dihydrochloride | 173897-44-4 | 98.81% | 353.25 | 25 MG
Y-33075 dihydrochloride is a selective ROCK inhibitor with an IC50 of 3.6 nM.
- Selective ROCK inhibitor with an IC50 of 3.6 nM.
- Inhibits PKC (IC50 of 420 nM) and CaMKII (IC50 of 810 nM) more potently than Y-27632.
- Extends neurites in retinal ganglion cells (RGCs).
- Inhibits the contraction of rabbit ciliary artery segments evoked by histamine in Ca2+-free solutions.
- Significantly lowers intraocular pressure (IOP) in rabbits and monkeys after topical administration.
- Increases regenerating axons of retinal ganglion cells (RGCs) in rats.
eMolecules 115445-31-3 | 3-(Trifluoroacetamido)pyrrolidine hydrochloride | Oakwood Chemical | MFCD01090944 | 218.600 | C6H10ClF3N2O | 98.000 | Cl.FC(F)(F)C(=O)NC1CCNC1 | 1g | 537671980
3-(Trifluoroacetamido)pyrrolidine hydrochloride | Oakwood Chemical | 115445-31-3 | MFCD01090944 | 218.600 | C6H10ClF3N2O | 98.000 | Cl.FC(F)(F)C(=O)NC1CCNC1 | 1g | 537671980
Medchemexpress LLC Tirofiban hydrochloride monohydrate | 150915-40-5 | 99.9% | 495.07 | 500 MG
Tirofiban hydrochloride monohydrate is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist. It inhibits fibrinogen binding to this receptor and demonstrates antithrombotic activity. This compound also induces proliferation and migration on endothelial cells by stimulating VEGF production, and can significantly reduce myocardial no-reflow and ischemia-reperfusion injury by improving myocardial microvascular structural and endothelial dysfunction in ischemic areas.
- Selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist
- Inhibits fibrinogen binding
- Antithrombotic activity
- Induces proliferation and migration on endothelial cells
- Stimulates VEGF production
- Reduces myocardial no-reflow and ischemia-reperfusion injury
- Alleviates myocardial microvascular dysfunction
Medchemexpress LLC MLN120B dihydrochloride | 1782573-78-7 | C19H17Cl3N4O2 | 25 MG
MLN120B dihydrochloride is a potent, ATP competitive, and orally active inhibitor of IKKβ with an IC50 of 60 nM. This compound has demonstrated effectiveness in inhibiting multiple myeloma cell growth both in vitro and in vivo, and is also applicable for research related to rheumatoid arthritis.
- Potent, ATP competitive, and orally active IKKβ inhibitor
- Inhibits multiple myeloma cell growth in vitro and in vivo
- Can be used for research of rheumatoid arthritis
Medchemexpress LLC Benzamide, 4-butoxy-N-(2,4-difluorophenyl)- | 433967-28-3 | C17H17F2NO2 | 5 MG
VU 0357121 is a positive and highly selective mGlu5R allosteric modulator (PAM) with an EC50 of 33 nM. It is inactive or very weakly antagonizing at other mGlu receptor subtypes, enhancing glutamate sensitivity of mGlu5 likely due to interaction at a site on the receptor distinct from the MPEP binding site.
- Positive and highly selective mGlu5R allosteric modulator
- EC50 of 33 nM for mGlu5 receptor
- Inactive or very weakly antagonizing at other mGlu receptor subtypes
- Enhances glutamate sensitivity of mGlu5
- Does not bind at the MPEP allosteric site of mGlu5
Medchemexpress LLC Duloxetine | 116539-59-4 | 99.9% | 50 MG
Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM. It is used for the treatment of major depressive disorder and generalized anxiety disorder (GAD). For research use only; not sold to patients. Duloxetine inhibits the reuptake of serotonin and norepinephrine in the central nervous system. It is also considered a less potent inhibitor of dopamine reuptake. Duloxetine has no significant affinity for dopaminergic, adrenergic, cholinergic, histaminergic, opioid, glutamate, and GABA receptors, making it a selective reuptake inhibitor at the 5-HT and NA transporters.
- Inhibits serotonin and norepinephrine reuptake
- Treats major depressive disorder and generalized anxiety disorder
- Acts as a less potent inhibitor of dopamine reuptake
- Functions as a selective reuptake inhibitor at 5-HT and NA transporters
- For research use only
eMolecules 121010-86-4 | (R)-3-Aminopyrrolidin-2-one | MFCD11501145 | 1g
Ambeed | 3-Bromo-2-hydroxybenzonitrile | 1g | 552745984 | A597142 | 13073-28-4 | MFCD11042854 | 198.019 | C7H4BrNO
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Medchemexpress LLC Zk756326 dihydrochloride | 1780259-94-0 | MFCD09038571 | 99.9% | 429.38 | C21H30Cl2N2O3 | 1 ML
ZK756326 dihydrochloride is a small-molecule, nonpeptide agonist of the CC chemokine receptor CCR8 supplied for research use in biochemical and cell-based assays. It is available as a 10 mM solution in DMSO (1 mL) and as crystalline solids, and is provided with analytical documentation to verify identity and purity.
- Nonpeptide CCR8 agonist suitable for receptor pharmacology studies.
- Offered as 10 mM solution in DMSO (1 mL) and in multiple solid quantities for assay flexibility.
- High purity (99.87%) supporting reproducible experimental results.
- Comes with analytical documentation: COA, HNMR, LCMS, and SDS.
- Storage guidance for stability: sealed storage; in solvent, -80°C (6 months) or -20°C (1 month).
Medchemexpress LLC M4K2163 dihydrochloride | 2863635-04-3 | 98.3% | 480.40 | C24H28Cl2FN3O2 | 10 MG
M4K2163 dihydrochloride is a potent, selective activin receptor-like kinase-2 (ALK2) inhibitor with blood-brain barrier permeability intended for preclinical CNS research. It displays an IC50 of 19 nM and is supplied as a high-purity solid for laboratory use.
- Potent, selective ALK2 inhibitor (IC50 = 19 nM).
- Blood-brain barrier permeable, suitable for central nervous system research.
- High purity (98.3%) and characterized solid form (white to yellow).
- Molecular weight 480.40; formula C24H28Cl2FN3O2.
- Storage: sealed at -20°C; in solvent, -80°C for 6 months, -20°C for 1 month.
- Available in 10 mg vial for laboratory use.
Medchemexpress LLC DAPI dihydrochloride | 28718-90-3 | 99.9% | 25 MG
DAPI dihydrochloride | 28718-90-3 | 99.9% | 25 MG
![eMolecules 2711-58-2 | 5-Fluorotryptamine hydrochloride | Chem-Impex | MFCD00051081 | 214.670 | C10H12ClFN2 | 95.000 | Cl.NCCc1c[nH]c2ccc(F)cc12 | 1g | 112755761](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502177869.JPG-250.jpg)
eMolecules 2711-58-2 | 5-Fluorotryptamine hydrochloride | Chem-Impex | MFCD00051081 | 214.670 | C10H12ClFN2 | 95.000 | Cl.NCCc1c[nH]c2ccc(F)cc12 | 1g | 112755761
5-Fluorotryptamine hydrochloride | Chem-Impex | 2711-58-2 | MFCD00051081 | 214.670 | C10H12ClFN2 | 95.000 | Cl.NCCc1c[nH]c2ccc(F)cc12 | 1g | 112755761