Hydrochlorides
Medchemexpress LLC TP0427736 hydrochloride | 2459963-17-6 | 99.2% | 334.85 | C14H11ClN4S2 | 5 MG
TP0427736 hydrochloride is a potent ALK5 (TGF-β receptor I) kinase inhibitor supplied as the hydrochloride salt for laboratory research use. It has reported biochemical potency (IC50 2.72 nM), a molecular weight of 334.85 g/mol, and a reported purity of 99.22%.
- Potent ALK5 kinase inhibitor (IC50 2.72 nM).
- Provided as hydrochloride salt to improve solubility for assays.
- High reported purity suitable for research applications.
- Available in small pack sizes for screening and assay development.
- Molecular weight 334.85 g/mol.
Medchemexpress LLC TP0427736 hydrochloride | 2459963-17-6 | 99.2% | 334.85 | C14H11ClN4S2 | 25 MG
TP0427736 hydrochloride is a research-grade small-molecule inhibitor of ALK5 (TGF-β type I receptor), provided as the hydrochloride salt with characterized purity, molecular weight, solubility, and storage recommendations. It is intended for biochemical and cellular studies of TGF-β/Smad signaling.
- High purity (>99%) suitable for research applications.
- Potent ALK5 inhibition with low-nanomolar IC50 values.
- Available in milligram pack sizes for assay development and screening.
- Soluble in water and DMSO with published solubility conditions.
- Stored under low-temperature conditions to preserve stability.
Medchemexpress LLC TP0427736 hydrochloride | 2459963-17-6 | 99.2% | 334.85 | C14H11ClN4S2 | 100 MG
TP0427736 hydrochloride is a research-grade small-molecule inhibitor of the TGF-β type I receptor kinase (ALK5) used for biochemical and cell-based studies. It potently inhibits ALK5 kinase activity and reduces Smad2/3 phosphorylation in cellular assays, making it suitable for research on TGF-β/Smad signaling and related applications.
- Potent ALK5 inhibition, IC50 = 2.72 nM.
- Cellular activity: inhibits Smad2/3 phosphorylation in A549 cells, IC50 = 8.68 nM.
- High reported purity (99.22%).
- Supplied as the hydrochloride salt; available in research pack sizes including 100 mg.
- Molecular weight 334.85 g·mol-1; formula C14H11ClN4S2.
Medchemexpress LLC Tp0427736 hydrochloride | 2459963-17-6 | 99.2% | 334.85 | C14H11ClN4S2 | 50 MG
TP0427736 hydrochloride is the hydrochloride salt of a potent ALK5 (TGF-β type I receptor) kinase inhibitor for in vitro and preclinical research. It inhibits ALK5 with low-nanomolar potency and reduces Smad2/3 phosphorylation in cellular assays.
- Potent ALK5 inhibitor (ALK5 IC50 2.72 nM).
- Selective over ALK3 (ALK3 IC50 836 nM).
- Reduces Smad2/3 phosphorylation in A549 cells induced by TGF-β1 (8.68 nM).
- Molecular weight 334.85.
- Chemical formula C14H11ClN4S2.
- Purity 99.22%.
- Solid supplied as a 50 mg vial for laboratory research.
![Medchemexpress LLC 6-(4-(4-methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride | 2459963-17-6 | MFCD32633583 | 99.2% | 334.85 g/mol | C14H11ClN4S2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000308312.png-250.jpg)
Medchemexpress LLC 6-(4-(4-methylthiazol-2-yl)-1H-imidazol-5-yl)benzo[d]thiazole hydrochloride | 2459963-17-6 | MFCD32633583 | 99.2% | 334.85 g/mol | C14H11ClN4S2 | 10 MG
TP0427736 hydrochloride is a research-grade small-molecule ALK5 (TGF-β receptor I) inhibitor supplied as the hydrochloride salt. The compound is provided as a high-purity solid intended for in vitro biochemical and cellular studies, with documented solubility in water and DMSO and recommended cold storage for long-term stability.
- High purity suitable for research assays.
- Hydrochloride salt form improves aqueous and DMSO solubility.
- Documented solubility values aid experimental planning.
- Stable when stored as powder at recommended cold temperatures.
- Appropriate for pathway, target validation, and pharmacology studies.