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Hydrochlorides

An organic complex formed of an organic base in association with hydrogen chloride; also known as chlorhydrate, and as an acid salt.

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1

Medchemexpress LLC Zm323881 (hydrochloride) | 193000-39-4 | C22H19ClFN3O2 | 50 MG
SDP

ZM323881 hydrochloride is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM. It is an anilinoquinazoline that potently inhibits VEGFR2 (KDR) tyrosine kinase activity, demonstrating excellent selectivity versus other receptor tyrosine kinases. It inhibits VEGF-A-induced endothelial cell proliferation (IC50=8 nM) and VEGFR2 tyrosine phosphorylation, making it suitable for research applications.

  • Potent and selective VEGFR2 inhibitor
  • Anilinoquinazoline structure
  • Inhibits VEGF-A-induced endothelial cell proliferation
  • Inhibits VEGFR2 tyrosine phosphorylation
  • For research use only

ENCOMPASS_PREFERRED
2

Medchemexpress LLC Zm323881 hydrochloride | 193000-39-4 | C22H19ClFN3O2 | 25 MG
SDP

ZM323881 hydrochloride is a potent and selective VEGFR2 inhibitor with an IC50 of less than 2 nM. This anilinoquinazoline potently inhibits VEGFR2 (KDR) tyrosine kinase activity, showing excellent selectivity over other receptor tyrosine kinases. It inhibits VEGF-A-induced endothelial cell proliferation and VEGFR2 tyrosine phosphorylation.

  • Potent and selective VEGFR2 inhibitor (IC50 < 2 nM)
  • Inhibits VEGFR2 (KDR) tyrosine kinase activity
  • Excellent selectivity over other receptor tyrosine kinases
  • Inhibits VEGF-A-induced endothelial cell proliferation (IC50 = 8 nM)
  • Inhibits VEGFR2 tyrosine phosphorylation
  • Blocks activation of VEGFR-2, while sparing VEGFR-1, EGFR, PDGFR, and HGF receptor
  • For research use only

ENCOMPASS_PREFERRED
3

Medchemexpress LLC ZM323881 hydrochloride | 193000-39-4 | C22H19ClFN3O2 | 1 ML
SDP

ZM323881 hydrochloride is a potent and selective inhibitor of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) with an IC50 of less than 2 nM. This anilinoquinazoline specifically targets VEGFR2 tyrosine kinase activity, demonstrating excellent selectivity over other receptor tyrosine kinases.

  • Potent and selective VEGFR2 inhibitor
  • High purity (99.63%)
  • Specifically targets VEGFR2 tyrosine kinase activity
  • Exhibits excellent selectivity over other receptor tyrosine kinases
  • Inhibits VEGF-A-induced endothelial cell proliferation
  • Inhibits VEGFR2 tyrosine phosphorylation
  • Molecular Weight: 411.86
  • Formula: C22H19ClFN3O2
  • Appearance: Solid, light yellow to yellow

ENCOMPASS_PREFERRED
4

Medchemexpress LLC ZM323881 (hydrochloride) | 193000-39-4 | 99.6% | 411.86 | 10 MG
SDP

ZM323881 (hydrochloride) | 193000-39-4 | 99.6% | 411.86 | 10 MG

ENCOMPASS_PREFERRED
5

Medchemexpress LLC 1-[(4-phenylphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione | 1208222-39-2 | MFCD22683818 | 99.4% | 397.35 g/mol | C22H14F3NO3 | 1 ML
SDP

VU 0365114 is a selective muscarinic acetylcholine receptor (mAChR) M5 positive allosteric modulator used in research to probe M5 receptor pharmacology and β-cell insulin secretion. It displays an EC50 of 2.7 μM at M5 and EC50 >30 μM at M1-M4, enabling selective modulation of M5-mediated responses.

  • Selective positive allosteric modulation of mAChR M5.
  • EC50 2.7 μM at M5 and EC50 >30 μM at M1-M4, indicating high selectivity.
  • Enhances acetylcholine-stimulated insulin secretion in human β-cells.
  • Available as solid or as a 10 mM solution in DMSO for flexible application.
  • High purity suitable for biochemical and cellular assays.

ENCOMPASS_PREFERRED
6

Medchemexpress LLC 1-([1,1'-biphenyl]-4-ylmethyl)-5-(trifluoromethoxy)indoline-2,3-dione | 1208222-39-2 | MFCD22683818 | 99.4% | 397.35 g·mol^-1 | C22H14F3NO3 | 10 MG
SDP

VU 0365114 is a selective muscarinic acetylcholine receptor (mAChR) M5 positive allosteric modulator used in research to potentiate M5-mediated signaling. It displays an EC50 of 2.7 μM for M5 with minimal activity at M1-M4 and has been reported to increase acetylcholine-stimulated insulin secretion in human β-cells.

  • Selective mAChR M5 positive allosteric modulator.
  • Potentiates M5 responses with EC50 of 2.7 μM.
  • Minimal activity at M1-M4 receptors (EC50 > 30 μM).
  • High purity solid with light yellow to orange appearance.
  • Chemical formula C22H14F3NO3; molecular weight 397.35 g·mol⁻¹.
  • Intended for biochemical and pharmacological research applications.

ENCOMPASS_PREFERRED