Organic lead salts
Apexbio Technology LLC Irinotecan HCl Trihydrate(Synonyms: Campto, Camptosar, CPT-11, Irinotecan hydrochloride trihydrate, Irinotecan hydrochloride, Irinotecan HCl, Irinotecan, CPT 11 hydrochloride trihydrate), 10mM (in 1mL DMSO), CAS: 136572-09-3.
Irinotecan HCl Trihydrate (CAS 136572-09-3) also known as CPT-11 is a semisynthetic derivative of camptothecin designed to improve therapeutic efficacy while reducing toxicity It acts as a soluble prodrug which undergoes enzymatic cleavage by carboxylesterases in vivo to yield SN-38 a potent inhibitor of topoisomerase I CPT-11 exhibits cytotoxicity against leukemia (P388) cell lines with an IC50 of 3 4 M and demonstrates antitumor activity in vitro and in vivo against both drug-sensitive and multidrug-resistant tumor models It is FDA-approved for treating metastatic colorectal cancer following progression after fluorouracil-based therapies
Apexbio Technology LLC Peramivir Trihydrate 1041434-82-5 50mg
Peramivir Trihydrate (CAS 1041434-82-5) is a small-molecule inhibitor targeting influenza viral neuraminidase It is designed to inhibit neuraminidase activity thereby impeding viral particle release and the spread of infection Peramivir Trihydrate exerts its biological activity primarily through competitive inhibition of neuraminidase as a transition-state analog In experimental studies Peramivir Trihydrate demonstrates neuraminidase inhibitory activity with an IC50 of approximately 0 09 nM Based on these pharmacological properties Peramivir Trihydrate holds research potential in investigating influenza virus replication antiviral efficacy and neuraminidase-mediated viral dissemination
Apexbio Technology LLC Peramivir Trihydrate 1041434-82-5 10mg
Peramivir Trihydrate (CAS 1041434-82-5) is a small-molecule inhibitor targeting influenza viral neuraminidase It is designed to inhibit neuraminidase activity thereby impeding viral particle release and the spread of infection Peramivir Trihydrate exerts its biological activity primarily through competitive inhibition of neuraminidase as a transition-state analog In experimental studies Peramivir Trihydrate demonstrates neuraminidase inhibitory activity with an IC50 of approximately 0 09 nM Based on these pharmacological properties Peramivir Trihydrate holds research potential in investigating influenza virus replication antiviral efficacy and neuraminidase-mediated viral dissemination
Apexbio Technology LLC Vardenafil HCl Trihydrate 330808-88-3 10mg
Vardenafil HCl Trihydrate (CAS 330808-88-3) is the trihydrate salt form of vardenafil a potent and selective inhibitor of phosphodiesterase type 5 (PDE5) In enzymatic assays vardenafil demonstrates an IC50 of 0 7 nM for PDE5 exhibiting high selectivity over other phosphodiesterase isoforms with significantly higher IC50 values for PDE1 PDE2 PDE3 PDE4 and PDE6 Vardenafil enhances relaxation of human trabecular smooth muscle in response to sodium nitroprusside acetylcholine and electrical stimulation and increases cGMP concentrations in human corpus cavernosum tissue These properties establish its utility in studies addressing cGMP-mediated smooth muscle relaxation and PDE5-related pharmacology
Apexbio Technology LLC Vardenafil HCl Trihydrate 330808-88-3 10mM (in 1mL DMSO)
Vardenafil HCl Trihydrate (CAS 330808-88-3) is the trihydrate salt form of vardenafil a potent and selective inhibitor of phosphodiesterase type 5 (PDE5) In enzymatic assays vardenafil demonstrates an IC50 of 0 7 nM for PDE5 exhibiting high selectivity over other phosphodiesterase isoforms with significantly higher IC50 values for PDE1 PDE2 PDE3 PDE4 and PDE6 Vardenafil enhances relaxation of human trabecular smooth muscle in response to sodium nitroprusside acetylcholine and electrical stimulation and increases cGMP concentrations in human corpus cavernosum tissue These properties establish its utility in studies addressing cGMP-mediated smooth muscle relaxation and PDE5-related pharmacology
Medchemexpress LLC Cefixime (trihydrate) | 125110-14-7 | 99.8% | 507.50 g·mol⁻¹ | C16H21N5O10S2 | 10 MG
Cefixime trihydrate is a third-generation cephalosporin antibiotic used as a research reagent and analytical standard for studying antibacterial activity and for analytical testing.
- Third-generation cephalosporin antibiotic.
- High purity analytical standard (COA example 99.77%).
- White to off-white solid, easily handled in laboratory settings.
- Molecular weight 507.50 g·mol⁻¹; molecular formula C16H21N5O10S2.
- CAS number 125110-14-7 for unambiguous identification.
- Recommended storage: powder -20°C (3 years) or 4°C (2 years); in solvent -80°C (6 months) or -20°C (1 month).
Apexbio Technology LLC VO-Ohpic trihydrate 476310-60-8 10mg
VO-Ohpic trihydrate (CAS 476310-60-8) is a highly selective small-molecule inhibitor of the lipid phosphatase PTEN (phosphatase and tensin homolog) with an in vitro IC50 of 35 nM VO-Ohpic shows marked selectivity for PTEN over other phosphatases including CBPs SopB myotubularin SAC1 and PTP- In cell-based assays VO-Ohpic induces dose-dependent phosphorylation of Akt at Ser473 and Thr308 saturating at 75 nM and promotes Akt functional activation as indicated by decreased FoxO3a transcriptional activity In vivo VO-Ohpic administration in MDA PCa-2b tumor xenograft mice results in reduced tumor growth and increased survival This compound serves as a valuable tool for investigating PTEN function and its modulation in insulin signaling glucose uptake and cancer research
Apexbio Technology LLC VO-Ohpic trihydrate 476310-60-8 25mg
VO-Ohpic trihydrate (CAS 476310-60-8) is a highly selective small-molecule inhibitor of the lipid phosphatase PTEN (phosphatase and tensin homolog) with an in vitro IC50 of 35 nM VO-Ohpic shows marked selectivity for PTEN over other phosphatases including CBPs SopB myotubularin SAC1 and PTP- In cell-based assays VO-Ohpic induces dose-dependent phosphorylation of Akt at Ser473 and Thr308 saturating at 75 nM and promotes Akt functional activation as indicated by decreased FoxO3a transcriptional activity In vivo VO-Ohpic administration in MDA PCa-2b tumor xenograft mice results in reduced tumor growth and increased survival This compound serves as a valuable tool for investigating PTEN function and its modulation in insulin signaling glucose uptake and cancer research