CYM5442 is a potent, highly-selective, and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC50 of 1.35 nM. It is inactive against S1P2, S1P3, S1P4, and S1P5. This compound activates S1P1-dependent p42/p44-MAPK phosphorylation, exerts retinal neuroprotection, and can easily penetrate the central nervous system (CNS).
- Potent and highly-selective S1P1 receptor agonist
- Orally active
- Inactive against S1P2, S1P3, S1P4, and S1P5
- Activates S1P1-dependent p42/p44-MAPK phosphorylation
- Exerts retinal neuroprotection
- Easily penetrates the central nervous system (CNS)