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Etiocholanolone (5β-Androsterone) is a metabolite of testosterone that exhibits anticonvulsant activity. It functions as a less potent neurosteroid positive allosteric modulator (PAM) of the GABAA receptor compared to its enantiomer form. It is intended for research use only and is not sold to patients.
Excreted metabolite of testosterone.
Possesses anticonvulsant activity.
Acts as a neurosteroid positive allosteric modulator (PAM) of the GABAA receptor.
Available in various quantities, including solid and solution forms.
Documentation includes Data Sheet, COA, SDS, and Handling Instructions.
Solubility information and stock solution preparation guidance are provided.
In vivo dissolution protocols are available for different administration routes and animal experiments.
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cIAP1 ligand 1 is an LCL161 derivative based IAP ligand that can be used in prostate cancer research. It can be connected to the ABL ligand for protein by a linker to form SNIPER. This product is a PROTAC, which are heterobifunctional nanomolecules that exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
LCL161 derivative based IAP ligand
Can be connected to ABL ligand for protein by a linker to form SNIPER
Useful in prostate cancer research
Exploits intracellular ubiquitin-proteasome system to selectively degrade target proteins
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Bis-propargyl-PEG4 is a PEG4-based bifunctional linker bearing terminal propargyl (alkyne) groups. It is designed for click chemistry and PROTAC linker synthesis, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAC) for conjugation to azide-bearing partners.
Peg4 linker with terminal propargyl (alkyne) groups.
Enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation.
Suited for PROTAC synthesis and small-molecule dimer formation.
Defined molecular weight and formula for predictable stoichiometry.
Available in milligram to gram packaging for research use.
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T16Ainh-A01 is an aminophenylthiazole small-molecule inhibitor of the calcium-activated chloride channel TMEM16A (ANO1). It inhibits TMEM16A-mediated chloride currents with an IC50 of approximately 1 μM and is supplied as a white to off-white solid for research use. Solubility: DMSO 83.33 mg/mL; DMF ≥10 mg/mL. Storage: powder -20°C (up to 3 years); in solvent -80°C (6 months), -20°C (1 month).
Inhibits TMEM16A with IC50 ≈ 1 μM.
High purity (99.04%) for reproducible results.
White to off-white solid suitable for analytical and biological assays.
High solubility in DMSO and good solubility in DMF.
Long-term powder stability at -20°C; defined solvent storage durations.
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Sec61-IN-1 is a potent sec61 inhibitor, which effectively targets glioma cells and enhances T cell cytotoxic effects. It has demonstrated efficacy in both in vitro and in vivo studies.
Enhances T cell cytotoxicity in U87 glioma cells
Exhibits lower IC50 for cytotoxicity in GBM12 and GBM38 PDX cell lines with SEC61G-EGFR dual amplification
Detected in mouse brain tissue 45 minutes after intravenous injection
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