Dimethyl Sulfoxide
Apexbio Technology LLC Losmapimod 585543-15-3 10mM (in 1mL DMSO)
Losmapimod (CAS 585543-15-3) also known as GW856553 is a selective orally bioavailable inhibitor of p38 mitogen-activated protein kinase (MAPK) It exhibits potent inhibitory activity against p38 and p38 isoforms with reported pKi values of 8 1 and 7 6 respectively By inhibiting p38 MAPK a kinase essential in inflammatory signaling pathways and cytokine production Losmapimod has demonstrated beneficial effects in preclinical and clinical models It improves nitric oxide-mediated vasodilation and reduces markers of systemic inflammation such as C-reactive protein and fibrinogen This molecule is utilized in research studies addressing inflammation-driven cardiovascular disorders hypercholesterolemia and chronic obstructive pulmonary disease (COPD)
Apexbio Technology LLC Fluvastatin Sodium 93957-55-2 10mM (in 1mL DMSO)
Fluvastatin Sodium (CAS 93957-55-2) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase the rate-limiting enzyme in cholesterol biosynthesis By blocking HMG-CoA reductase activity fluvastatin reduces serum total cholesterol LDL-cholesterol and apolipoprotein B while increasing HDL-cholesterol and apolipoprotein A-I levels In research settings fluvastatin exhibits anti-atherosclerotic anti-thrombotic and antioxidant properties Studies have shown fluvastatin decreases platelet aggregation dose-dependently in vitro reducing platelet aggregation by approximately 10-15% at clinical doses (40 mg/day) Additionally fluvastatin inhibits inflammatory angiogenesis and NO production suggesting potential applications in inflammatory and cardiovascular research
Apexbio Technology LLC PF-3758309 898044-15-0 10mM (in 1mL DMSO)
PF-3758309 (CAS 898044-15-0) is a selective ATP-competitive inhibitor of p21-activated kinase 4 (PAK4) a serine/threonine kinase involved in cytoskeletal reorganization and cellular signaling mediated by Cdc42-GTP and JNK-GTP interactions PF-3758309 inhibits phosphorylation of PAK4 substrates (e g GEF-H1 IC50 1 3 nM) and suppresses PAK4-mediated anchorage-independent growth In xenograft tumor models (HCT116 A549) oral administration of PF-3758309 significantly reduced tumor growth demonstrating its utility in research investigating PAK-dependent oncogenic pathways
Apexbio Technology LLC BML-277 516480-79-8 10mM (in 1mL DMSO)
BML-277 (CAS 516480-79-8) is a potent ATP-competitive inhibitor of checkpoint kinase 2 (Chk2) with an IC50 of approximately 15 nM and a Ki value of 37 nM Mechanistically BML-277 binds specifically to the ATP-binding site of Chk2 blocking its kinase activity In cellular assays BML-277 demonstrates concentration-dependent protective effects against irradiation-induced apoptosis in T-cells with EC50 values ranging from 3 to 7 6 M Due to its selective Chk2 inhibition BML-277 serves as a valuable reagent in studying DNA damage checkpoint pathways and their roles in cell survival and apoptosis
Apexbio Technology LLC RGFP966 1357389-11-7;1396841-57-8 10mM (in 1mL DMSO)
RGFP966 is a selective inhibitor targeting histone deacetylase 3 (HDAC3) demonstrating an IC50 value of approximately 80 nM HDAC3 a Class I histone deacetylase regulates DNA transcription and influences chromatin structure replication and DNA repair It negatively regulates cognitive mechanisms such as learning and memory processes RGFP966 selectively inhibits HDAC3 without affecting other HDAC isoforms at concentrations up to 15 M as demonstrated by substrate-dependent assays In preclinical research RGFP966 has been utilized to investigate HDAC3 s role in neural functions particularly object recognition memory and to examine cellular effects including growth inhibition and apoptosis induction in models of cutaneous T-cell lymphoma
Apexbio Technology LLC URB597(Synonyms: URB-597, KDS-4103, FAAH inhibitor URB597, Cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester), 10mM (in 1mL DMSO), CAS: 546141-08-6.
URB597 (CAS 546141-08-6) also known as KDS-4103 is a potent and selective inhibitor of fatty acid amide hydrolase (FAAH) an enzyme responsible for intracellular hydrolysis of the endocannabinoid anandamide In vitro assays indicate that URB597 inhibits FAAH activity with IC values of 3 nM in human liver microsomes and 52 nM in rat brain membranes Intraperitoneal administration in rats results in FAAH inhibition within brain tissue (ID 0 15 mg/kg) URB597 exhibits minimal interaction with cannabinoid receptors anandamide transporters or other related receptors ion channels enzymes and transporters This selectivity makes URB597 valuable for investigating endocannabinoid signaling pathways in biomedical research