Tetrahydrofuran
Medchemexpress LLC 5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide | 2095849-04-8 | MFCD31813597 | 98.0% | 479.45 g/mol | C25H20F3N5O2 | 50 MG
CSF1R-IN-1 is a potent small-molecule inhibitor of the colony stimulating factor 1 receptor (CSF1R) with a reported IC50 of 0.5 nM. It shows good intestinal permeability in Caco-2 assays and favorable oral pharmacokinetics in mice. The compound is supplied as a solid for research use and includes standard storage recommendations and available solution formulations.
- Potent CSF1R inhibition (IC50 0.5 nM).
- Molecular formula C25H20F3N5O2; molecular weight 479.45 g/mol.
- High purity (98.04%).
- White to off-white solid physical form.
- Stable storage: powder -20°C for up to 3 years; in solvent -80°C for 6 months, -20°C for 1 month.
- Available in multiple sizes and as a 10 mM solution in DMSO.
Medchemexpress LLC Nelonicline | 1026134-63-3 | 99.8% | 313.42 g/mol | C17H19N3OS | 10 MG
Nelonicline is an orally active, selective agonist of the α7 nicotinic acetylcholine receptor supplied as a research reagent for preclinical and in vitro studies. It has molecular formula C17H19N3OS and molecular weight 313.42 g/mol. For research use only; not for clinical or diagnostic applications.
- Selective α7 nicotinic acetylcholine receptor agonist suitable for receptor pharmacology studies.
- Orally active small molecule compatible with in vivo and in vitro experiments.
- Available as a 10 MG solid and as a 10 mM solution in DMSO for assay use.
- High-purity research compound appropriate for preclinical studies.
- Supplied for research use only, not intended for therapeutic use.
Medchemexpress LLC Otaplimastat (SP-8203) | 1176758-04-5 | 98.11% | 534.61 | 50 MG
Otaplimastat (SP-8203) is a matrix metalloproteinase (MMP) inhibitor that competitively blocks N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity. It also exhibits anti-oxidant activity and can be used for research on brain ischemic injury.
- MMP inhibitor
- Blocks NMDA receptor-mediated excitotoxicity competitively
- Exhibits anti-oxidant activity
- Potential for research of brain ischemic injury
- Protects neuronal cells against NMDA-induced cell death
- Inhibits Ca2+ influx following activation of NMDA receptors in primary cultured neurons
- Suppresses H2O2-induced cell death and reactive oxygen species production
- Prevents ischemic neuronal death in the occlusion model of MCA in rats
- Attenuates impairment of stroke-induced motor function in rats
Medchemexpress LLC BDP9066 | 2226507-04-4 | 98.18% | 348.44 | 50 MG
BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase (MRCK) inhibitor. It inhibits MRCKβ with an IC50 of 64 nM in SCC12 cells and has Ki values of 0.0136 nM for MRCKα and 0.0233 nM for MRCKβ. This compound demonstrates a therapeutic effect on skin cancer by reducing substrate phosphorylation.
- Potent and selective inhibitor of MRCKα and MRCKβ.
- Exhibits antiproliferative effects, particularly in hematologic cancer cells.
- Inhibits MLC phosphorylation and blocks motility and invasion of SCC12 squamous cell carcinoma.
- Topical application significantly decreases phosphorylated MRCKα S1003 staining and tumor volumes.
Sigma Aldrich Fine Chemicals Biosciences Tetrahydrofuran | 109-99-9 | MFCD00005356 | 1 L
Tetrahydrofuran | Purity: 99% | Mol Wt: 72.11 | 109-99-9 | MFCD00005356 | 1 L
Medchemexpress LLC 5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide | 2095849-04-8 | MFCD31813597 | 98.0% | 479.45 g·mol⁻¹ | C25H20F3N5O2 | 5 MG
CSF1R-IN-1 is a potent small-molecule inhibitor of the colony-stimulating factor 1 receptor (CSF1R) with a reported IC50 of 0.5 nM. The compound demonstrates good intestinal permeability in Caco-2 assays and favorable oral pharmacokinetics in mice, supporting its use for in vivo pharmacology testing in preclinical tumor models.
- Potent CSF1R inhibition (IC50 = 0.5 nM).
- Good intestinal permeability in Caco-2 assays.
- Favorable oral pharmacokinetics in mice for in vivo studies.
- High purity suitable for research applications.
- Recommended storage as a powder at -20°C to maintain stability.
![Medchemexpress LLC Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate | 173436-66-3 | 99.8% | 100MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000232744.png-250.jpg)
Medchemexpress LLC Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate | 173436-66-3 | 99.8% | 100MG
Methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate | 173436-66-3 | 99.8% | 100MG
Sigma Aldrich Fine Chemicals Biosciences 2 Methyltetrahydrofuran Bi
We are committed to bringing you Greener Alternative Products which adhere to one or more of The 12 Principles of Greener Chemistry. This product is a biorenewable and thus aligns with Safer Solvents and Auxiliaries and Use of Renewable Feedstocks. Click here for more information.2-Methyltetrahydrofuran (2-MTHF) a 2-methyl substituted tetrahydrofuran is a biomass derived solvent. It is a potential greener solvent alternative for organic synthesis. It shows resistance to reduction by lithium making it a promising candidate as electrolytes in lithium batteries. Its polarity and Lewis base strength is intermediate between tetrahydrofuran (THF) and diethyl ether. The ring opening reaction of 2-MTHF has been studied using acid chloride and iodide.
Medchemexpress LLC L-745870 hydrochloride | 1173023-36-3 | 99.91% | C18H20Cl2N4 | 50 MG
L-745870 hydrochloride is a potent, selective, brain-penetrant, and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. It demonstrates weaker affinity for D2 and D3 receptors, and moderate affinity for 5-HT2 receptors, sigma sites, and α-adrenoceptors. This compound is valuable for research into dopamine receptor functions and potential therapeutic applications.
- Potent, selective, and orally active dopamine D4 receptor antagonist.
- Exhibits weaker affinity for D2 and D3 receptors.
- Good brain penetration and oral bioavailability in animal models.
- Antagonizes D4 receptor inhibition of agonist-induced [35S]-GTPγS binding.
- Blocks dopamine-induced inhibition of Ca2+ currents in GH4C1 cells.
- Inhibits D4 activation of G protein-coupled inwardly rectifying K+ channels.
Jade Scientific, Inc TETRAHYDROFURAN LAB PLUS 19L
Tetrahydrofuran Lab Plus 19l. 109-99-9 MFCD00005356