Tetrahydrofuran
Medchemexpress LLC BDP9066 | 2226507-04-4 | 98.2% | 348.44 | 10 MG
BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor. It has an IC50 of 64 nM for MRCKβ in SCC12 cells, and Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β respectively. It demonstrates a therapeutic effect on skin cancer by reducing substrate phosphorylation. This product is for research use only.
- Targets MRCKα (0.0136 nM (Ki)) and MRCKβ (0.0233 nM (Ki))
- Shows antiproliferative effects with greatest activity in hematologic cancer cells
- Inhibits MLC phosphorylation and blocks SCC12 squamous cell carcinoma motility and invasion
- Topical application significantly decreases phosphorylated MRCKα S1003 staining and tumor volumes
Sigma Aldrich Fine Chemicals Biosciences 2 Methyltetrahydrofuran 3 1KG
2 Methyltetrahydrofuran 3 1KG
Sigma Aldrich Fine Chemicals Biosciences Tetrahydrofuran suitable for HPLC, >=99.9%, inhibitor-free | 109-99-9 | MFCD00005356 | 4X4L
Tetrahydrofuran suitable for HPLC, >=99.9%, inhibitor-free | Purity: >=99.9% | Mol Wt: 72.11 | 109-99-9 | MFCD00005356 | 4X4L
Sigma Aldrich Fine Chemicals Biosciences Tetrahydrofuran | 109-99-9 | MFCD00005356 | 2l
Tetrahydrofuran | Purity: 99% | Mol Wt: 72.11 | 109-99-9 | MFCD00005356 | 2l
Medchemexpress LLC MPT0B392 | 1346169-92-3 | 99.6% | 404.44 g/mol | C19H20N2O6S | 100 MG
MPT0B392 is an orally active quinoline-derived microtubule-depolymerizing agent that activates c-Jun N-terminal kinase (JNK) and induces apoptosis. It inhibits tubulin polymerization and causes mitotic arrest, making it useful in cell biology and oncology research investigating microtubule dynamics and drug resistance mechanisms.
- High purity (≈99.6%) suitable for research assays.
- Solid powder, light yellow to yellow appearance.
- Well-characterized molecular properties (C19H20N2O6S, 404.44 g/mol).
- Documented storage stability in powder and solution.
- Biological activity: tubulin depolymerizer, JNK activator, apoptosis inducer.
- Includes CAS number for unambiguous identification.
Sigma Aldrich Fine Chemicals Biosciences Tetrahydrofuran anhydrous1L
Tetrahydrofuran (THf) is a saturated cyclic ether mainly used as an organic solvent. On long term storage it forms organic peroxides. This process can be suppressed by adding butylated hydroxytoluene (BHT) as a stabilizer. BHT removes the free radicals required for the peroxide formation. It constitutes the key fragment of various natural products (polyether antibiotics). THf forms double hydrate with hydrogen sulfide crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies.
Sigma Aldrich Fine Chemicals Biosciences Tetrahydrofuran d8 99.5 at10G
Tetrahydrofuran-d8 (THf-d8 TDf) is a deuterated NMR solvent containing 0.03% (v/v) TMS (tetramethylsilane). It is useful in NMR-based research and analyses. 1H NMR line shape analysis of the exchange rates of proton between methanol and acetic acid dissolved in THf-d8 was reported. It participates as a solvent in the synthesis of deuteriotris[bis(trimethylsilyl)amido]thorium and deuteriotris[bis(trimethylsiiyl)amido]uranium. Dynamic NMR spectroscopic study of 15N 15NAE-dipentadeuterophenylformamidine (DPfA) has been studied in THf-d8.
Medchemexpress LLC Protogracillin | 54848-30-5 | 1 MG
Protogracillin is a steroidal saponin isolated from the plant Dioscorea zingiberensis Wright. Steroidal saponins found in the rhizomes of this plant have the potential to reduce the risk of cardiovascular diseases through anti-thrombotic action. It is intended for research use only and not for sale to patients.
- It is a steroidal saponin.
- It is isolated from Dioscorea zingiberensis Wright.
- It has potential anti-thrombotic action.
- It has shown cytotoxicity against human CCRF-CEM cells with an IC50 of 1.77 μM.
- Its purity is 99.00%.
Sigma Aldrich Fine Chemicals Biosciences Tetrahydrofuran contains 250 ppm BHT as inhibitor, ACS reagent, >=99.0% | 109-99-9 | MFCD00005356 | 2.5L
Tetrahydrofuran contains 250 ppm BHT as inhibitor, ACS reagent, >=99.0% | Purity: >=99.0% | Mol Wt: 72.11 | 109-99-9 | MFCD00005356 | 2.5L
Medchemexpress LLC GW406108X 10mg | 1644443-92-4 | 10 MG
Small-molecule research inhibitor of Kif15 and ULK1 that blocks autophagic flux and is used in cellular and biochemical studies to probe autophagy and kinesin-related pathways. CAS 1644443-92-4; molecular formula C20H11Cl2NO4; molecular weight 400.21 g/mol.
- Selective Kif15 ATPase inhibitor (IC50 0.82 μM).
- ATP-competitive ULK1 inhibitor (pIC50 6.37; ~427 nM).
- High purity solid for research (98.0% reported by supplier).
- Molecular formula C20H11Cl2NO4; molecular weight 400.21 g/mol.
- Recommended storage: powder at -20 °C for long term or 4 °C for short term; in solution store at -80 °C for extended periods.
Medchemexpress LLC PD-1/PD-L1-in-23 | 2597056-04-5 | C32H30BrCl2N3O6 | 10MG
PD-1/PD-L1-IN-23 is a small-molecule research compound that inhibits the PD-1/PD-L1 immune checkpoint pathway. Supplied as a solid powder in milligram-scale packaging, it is intended for in vitro and preclinical studies to probe PD-1/PD-L1 interactions in biochemical and cellular assays.
- High purity (>98%).
- Chemical formula C32H30BrCl2N3O6; molecular weight 703.41 g/mol.
- Supplied as a solid powder suitable for dissolution in common laboratory solvents.
- Intended for in vitro and preclinical research use; not for clinical or human use.
- Useful for studies of PD-1/PD-L1 interaction and checkpoint inhibition assays.
Medchemexpress LLC CSF1R-IN-1 | 2095849-04-8 | MFCD31813597 | 98.0% | 479.45 g/mol | C25H20F3N5O2 | 100 MG
CSF1R-IN-1 is a potent small-molecule inhibitor of the colony stimulating factor 1 receptor (CSF1R) with subnanomolar enzymatic potency (IC50 = 0.5 nM). It has demonstrated good intestinal permeability and favorable oral pharmacokinetics in mice, supporting its use in preclinical in vivo pharmacology studies related to tumor-associated macrophage biology, cancer, and inflammation research.
- Potent CSF1R inhibition (IC50 = 0.5 nM).
- Suitable for preclinical in vivo pharmacology studies.
- Demonstrates good intestinal permeability in Caco-2 assays.
- Favorable oral pharmacokinetic profile in mice.
- Available in solid and DMSO solution formats for dosing flexibility.
- High reported purity for research use.
(m5U-m5C-A-m5C-m5U-m5U-m5U-m5C-A-m5U-A-A-m5U-G-m5C-m5U-G-G) | 1258984-36-9 | 98.9% | 7127.3 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000439679-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC RNA, [2'-O-(2-methoxyethyl)](P-thio)(m5U-m5C-A-m5C-m5U-m5U-m5U-m5C-A-m5U-A-A-m5U-G-m5C-m5U-G-G) | 1258984-36-9 | 98.9% | 7127.3 | 1 MG
Nusinersen sodium is an antisense oligonucleotide active molecule. It modifies the pre-messenger RNA splicing of the SMN2 gene, which promotes the production of full-length SMN protein. This action helps to improve spinal muscular atrophy. It is intended for research use only and not for sale to patients.
- Antisense oligonucleotide active molecule.
- Modifies pre-messenger RNA splicing of the SMN2 gene.
- Promotes production of full-length SMN protein.
- Improves spinal muscular atrophy.
- Demonstrated improvement in motor function, preservation of αMN number, reduced motor neuron degeneration, and rescued skeletal muscle fiber size and oxidative metabolism in a severe SMA mouse model.
eMolecules 109-99-9 | Tetrahydrofuran ACS | Oakwood Chemicals | MFCD00005356 | 72.107 | C4H8O | 99.000 | C1CCOC1 | 1l | 480133467
Tetrahydrofuran ACS | Oakwood Chemicals | 109-99-9 | MFCD00005356 | 72.107 | C4H8O | 99.000 | C1CCOC1 | 1l | 480133467
Medchemexpress LLC SU5214 | 186611-04-1 | 98.0% | 251.28 | 5 MG
SU5214 is a potent VEGFR2 inhibitor. It has been extracted from patent US5834504A and exhibits IC50s of 14.8 μM for FLK-1 and 36.7 μM for EGFR.
- Potent VEGFR2 inhibitor.
- Targets VEGFR.
- Acts on the Protein Tyrosine Kinase/RTK pathway.
- Soluble in DMSO at 100 mg/mL.
- Suitable for research purposes.