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Synthesized from the 5-carbon precursors isopentenyl diphosphate and dimethylallyl diphosphate; includes the carotenoids, which are precursors of vitamin A and also possess antioxidant effects.
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(rel)-ML-SI3 is a small-molecule TRPML1/3 inhibitor intended for preclinical and in vitro research. The compound is supplied as a white to off-white solid with high reported purity and is used as a pharmacological tool to study lysosomal calcium signaling, autophagy, and related cellular pathways.
High purity suitable for biochemical and cellular assays.
Solid form for convenient handling and storage.
Available in small-scale quantities for screening and optimization.
Applicable for studies of lysosomal function and autophagy-related mechanisms.
Molecular formula C23H31N3O3S and molecular weight 429.58 g·mol⁻¹ for reference.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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iso-VQA-ACC acetate is a substrate for constitutive proteasome. This chemical has a molecular weight of 625.63 (free base) and a purity of 99.48% by HPLC.
Can be stored as a powder at -80°C for 2 years or -20°C for 1 year.
When in solvent, store at -80°C for 6 months or -20°C for 1 month.
Requires sealed storage away from moisture.
Soluble in DMSO at 100 mg/mL (requires ultrasonication).
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Vitamin A Acetate is a small-molecule modulator involved in the regulation of cell growth differentiation and immune response It exerts its biological activity primarily through activation of retinoic acid receptors (RARs) which regulate gene transcription pathways associated with cell proliferation differentiation and immune functions In experimental studies Vitamin A Acetate influences cell morphology and growth in cultured rat glomerular epithelial cells and enhances interleukin-2 (IL-2)-producing T-cell populations in neonatal mouse lymphocytes Based on these pharmacological properties Vitamin A Acetate holds research potential in tumor inhibition immune response modulation and investigation of cell differentiation pathways
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An iridoid glycoside with diverse biological activities; reduces exudate volume and nitrite levels in a rat model of carrageenan-induced air pouch inflammation at 0.1 mg/pouch; prevents prevents carrageenan-induced paw edema in rats at 100 mg/kg, p.o.; reduces serum levels of ALT and AST and hepatic levels of MDA as well as decreases in hepatic levels of SOD and GPX in a rat model of high-fat diet-induced NASH at 50 and 100 mg/kg; prevents increases in apoptosis and decreases in the number of dopaminergic neurons in the substantia nigra in a mouse model of MPTP-induced Parkinson's disease at 100 mg/kg; improves motor coordination in the rotarod and swim tests in a rat model of Parkinson's disease
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Antitumor and anti-HIV agent. Induces apoptosis by activating mitochondrial permeability transition (MPT). Inhibits NF-κB activation and NF-κB-regulated gene expression induced by carcinogens and inflammatory stimuli. Decreases expression of Bcl-2 and cyclin D1. Potent proteasome activator. Alternative name: 3beta-Hydroxy-20(29)-lupaene-28-oic acid. Purity: ≥90% (HPLC). Appearance: White to off-white powder. Solubility: Soluble in DMSO. Long Term Storage: +4°C.
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