Prenol lipids
![Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000387735-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 1H-Indole-2,3-dione, 5-chloro-1-[(2,5-dichlorophenyl)methyl]-, 3-(O-acetyloxime) | 668467-91-2 | 98.9% | 397.64 | 1 ML
LDN-57444 is a reversible, competitive, and site-directed inhibitor of ubiquitin C-terminal hydrolase L1 (UCH-L1) with an IC50 of 0.88 μM and a Ki of 0.40 μM. It also suppresses UCH-L3 activity, with an IC50 of 25 μM.
- Inhibits UCH-L1 with high potency (IC50 of 0.88 μM, Ki of 0.40 μM) and suppresses UCH-L3 activity (IC50 of 25 μM).
- Inhibits 70% of Uch activity in hippocampal slices of mouse brain at 5 μM for 1 hour.
- Inhibits ubiquitin-proteasome activity dose-dependently (25-100 μM) in SK-N-SH cells.
- Induces apoptotic cell death, causes endoplasmic reticulum stress, and results in expression of spliced XBP-1 in SK-N-SH cells at 50 μM.
- Blocks the beneficial effect of V-Uch-L1 and worsens contextual conditioning performance in mice at 0.4 mg/kg (intraperitoneal injection).
- Purity: 98.93%.
Medchemexpress LLC Phytol (Standard) | 150-86-7 | 25 MG
Phytol (Standard) is an orally active diterpenoid alcohol that serves as an analytical standard. It can be extracted from chlorophyll and exhibits antioxidant, anti-inflammatory, anti-schistosomiasis, and antibacterial activities. This product is intended for research and analytical applications.
- Analytical standard for research and analytical applications
- Extracted from chlorophyll
- Exhibits antioxidant activity
- Exhibits anti-inflammatory activity
- Exhibits anti-schistosomiasis activity
- Exhibits antibacterial activity
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
Medchemexpress LLC Phytol | 150-86-7 | 1 ML
Phytol ((E)-Phytol) is an orally active diterpenoid alcohol extracted from chlorophyll. It exhibits antioxidant, anti-inflammatory, anti-schistosomiasis, and antibacterial activities. It is intended for research use only and not for sale to patients.
- Exhibits antioxidant activity
- Shows anti-inflammatory properties
- Possesses anti-schistosomiasis activity
- Demonstrates antibacterial activities
- Reduces motor activity and causes death in worms
- Inhibits osteoclast differentiation and oxidative stress
- Reduces parasite numbers in mice infected with C. mansoni
- Improves anemia and oxidative brain damage in Plasmodium berghei infected mice
Cayman Chemical Mulberry leaf Phytol 250g
A degradation product of chlorophyll that is converted to phytanic acid, which can accumulate to toxic levels in a number of metabolic disorders; activates RXRs (Kis range from 2.3-67.2 µM) and promotes the activity of PPAR/RXR heterodimers
Medchemexpress LLC Dihydrotanshinone I | 87205-99-0 | 278.30 | 100 MG
Dihydrotanshinone I is a natural compound extracted from *Salvia miltiorrhiza Bunge*, which has been widely used for treating cardiovascular diseases. It exhibits an entry-blocking effect for MERS-CoV.
- Natural compound extracted from *Salvia miltiorrhiza Bunge*.
- Used for treating cardiovascular diseases.
- Exhibits an entry-blocking effect for MERS-CoV.
Medchemexpress LLC Tanshinone IIA (Dan Shen ketone) | 568-72-9 | 99.78% | 294.34 | 5 MG
Tanshinone IIA is a primary component found in the root of Salvia miltiorrhiza Bunge. It may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2, and has anti-tumor effects including inhibiting tumor cell proliferation, disrupting the tumor cell cycle, promoting tumor cell apoptosis, and inhibiting tumor cell invasion and transfer.
- Has antiproliferative activity against various cell lines
- Protects rat myocardium-derived H9C2 cells against apoptosis
- Blocks the PI3K/Akt/mTOR pathway in gastric carcinoma AGS cells
Medchemexpress LLC Isotanshinone IIA | 20958-15-0 | 5 MG
Isotanshinone IIA is an abietane-type diterpene metabolite that non-competitively inhibits Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 of 11.4 μM. Intended for research use only, this product is an orange to orange-red solid with 98.0% purity. It has a molecular weight of 294.34 and a chemical formula of C19H18O3.
- Non-competitive inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) activity
- IC50 of 11.4 μM
- 98.0% purity
- Appears as an orange to orange-red solid
- Molecular weight of 294.34
- Chemical formula of C19H18O3
- Classified under Quinones and Naphthalene Quinones
- Powder storage: -20°C for 3 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO at 3 mg/mL (10.19 mM)
Medchemexpress LLC Dihydrotanshinone I | 87205-99-0 | 278.30 | 5 MG
Dihydrotanshinone I is a natural compound extracted from *Salvia miltiorrhiza Bunge*. This compound has been extensively used for treating cardiovascular diseases and demonstrates an entry-blocking effect against MERS-CoV.
- Extracted from *Salvia miltiorrhiza Bunge*
- Used for treating cardiovascular diseases
- Exhibits entry-blocking effect for MERS-CoV
- Attenuates atherosclerosis in ApoE-/- mice
- Inhibits LOX-1, NOX4, and NF-κB expression in aorta
- Improves cardiac function and reduces infarct size in myocardial ischemia-reperfusion rats
- Induces caspase-dependent apoptosis and autophagy in colon cancer cells
- Potentially a safe, high-throughput screening compound for MERS-CoV entry inhibitors
- Purity: 99.57%
- Appearance: Solid, brown to red
TARGETMOL CHEMICALS INC Cucurbitacin IIA 10MG
Also available in 1 mg, 5 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. 1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a novel class of anti-cancer drug in suppression of cancer cell expansion by disrupting the actin cytoskeleton and directing the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2/STAT3. Purity 98.62%
Medchemexpress LLC Tanshinone I | 568-73-0 | 98.8% | 276.29 | 100 MG
Tanshinone I is an inhibitor of type IIA human recombinant sPLA2 and rabbit recombinant cPLA2. It demonstrates anti-inflammatory activity in rat carrageenan-induced paw oedema and adjuvant-induced arthritis. It is for research use only.
- Inhibits type IIA human recombinant sPLA2 and rabbit recombinant cPLA2
- Shows anti-inflammatory activity in animal models
- For research use only
![Medchemexpress LLC Naphtho[1,2-b]furan-2,8(3H,4H)-dione, 3a,5,5a,9b-tetrahydro-3,5a,9-trimethyl- | 481-06-1 | 99.3% | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000411518-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Naphtho[1,2-b]furan-2,8(3H,4H)-dione, 3a,5,5a,9b-tetrahydro-3,5a,9-trimethyl- | 481-06-1 | 99.3% | 1 ML
Santonin is an active principle of the plant Artemisia cina, which was formerly used to treat worms.