Organic Acids
MEDCHEMEXPRESS LLC PF15 (TFA) | 99.7% | C46H50F3N13O8 | 25 MG
PF15 TFA is a PROTAC that connects ligands for FLT3 kinase and CRBN. It is a highly selective FLT3-ITD degrader with a DC50 of 76.7 nM. It significantly inhibits the proliferation of FLT3-ITD-positive cells and can down-regulate the phosphorylation of FLT3 and STAT5. It also inhibits tumor growth in mouse models and can be used in the study of leukemia.
- Connects ligands for FLT3 kinase and CRBN
- Highly selective FLT3-ITD degrader
- Has a DC50 of 76.7 nM
- Inhibits proliferation of FLT3-ITD-positive cells
- Down-regulates the phosphorylation of FLT3 and STAT5
- Inhibits tumor growth in mouse models
- Used in the study of leukemia
MEDCHEMEXPRESS LLC JPS014 TFA | 98.12% | C48H60F3N7O9S | 25 MG
JPS014 TFA is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC). It degrades class I histone deacetylase (HDAC) and is a potent HDAC1/2 degrader. This degradation correlates with a greater number of total differentially expressed genes and enhanced apoptosis in HCT116 cells.
- Benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimera (PROTAC)
- Degrades class I histone deacetylase (HDAC)
- Potent HDAC1/2 degrader
- Correlates with greater total differentially expressed genes
- Enhances apoptosis in HCT116 cells
MEDCHEMEXPRESS LLC Mifamurtide (TFA) | 98.0% | 1351.52 | 1 MG
Mifamurtide TFA (MTP-PE TFA) is an analog of the muramyl dipeptide (MDP) that functions as a nonspecific immunomodulator by stimulating the immune response, activating macrophages and monocytes. It is a specific ligand for NOD2 and acts as an insulin sensitizer, with potential applications in rare disease and osteosarcoma research.
- Induces reduction of MG63 cell numbers when co-cultured with macrophages.
- Increases M1 polarization marker iNOS and M2 polarization marker CD206 mRNAs.
- Increases pro-inflammatory (IL-1β, IL-6) and anti-inflammatory (IL-4, IL-10) cytokines.
- Activates macrophages and monocytes, leading to upregulation of tumoricidal activity and secretion of pro-inflammatory cytokines.
- Shows a trend of diminished spontaneous lung metastasis dissemination in osteosarcoma models.
- Improves glucose tolerance during endotoxemia and in HFD-fed mice.
MEDCHEMEXPRESS LLC Pamoic acid | 130-85-8 | 99.69% | 388.38 | 5 G
Pamoic acid (Embonic acid) is a potent GPR35 agonist with an EC50 of 79 nM. It exhibits neuroprotective and anti-inflammatory properties.
- Potent GPR35 agonist with an EC50 of 79 nM.
- Exhibits neuroprotective properties.
- Exhibits anti-inflammatory properties.
MEDCHEMEXPRESS LLC Citric acid (tripotassium hydrate) | 6100-05-6 | 98.0% | 324.41 | 5 G
Citric acid tripotassium hydrate (Potassium citrate monohydrate) is a natural preservative and food tartness enhancer. It induces apoptosis and cell cycle arrest at G2/M and S phases in HaCaT cells. This compound can cause oxidative damage to the liver by decreasing antioxidative enzyme activities. It also serves as an acidulant, emulsifier, sequestrant, and buffering agent with wide applications across various industries. It is intended for research use only.
- Natural preservative
- Food tartness enhancer
- Induces apoptosis and cell cycle arrest in HaCaT cells
- Acidulant, emulsifier, sequestrant, and buffering agent
- Available as a solid, white to off-white in color
- Soluble in water (120 mg/mL)