Organic Acids
Medchemexpress LLC FRETS-VWF73 | 97.3% | 8314.28 | 1 MG
FRETS-VWF73 is a 73-amino-acid peptide that serves as a fluorogenic substrate for the ADAMTS13 assay (Ex = 340 nm; Em = 450 nm). It is utilized as a predictive tool for thrombotic thrombocytopenic purpura and is intended for research use only.
- Functions as a fluorogenic substrate for ADAMTS13 assay
- Predictive tool for thrombotic thrombocytopenic purpura
- Excitation wavelength: 340 nm
- Emission wavelength: 450 nm
- Purity: 97.3%
- Molecular weight: 8314.28
- Appearance: Solid, light yellow to yellow
- Solubility: 25 mg/mL in DMSO
Medchemexpress LLC Vasculotide TFA | 1359657-45-6 | 99.7% | 14000 (average) | 25 MG
Vasculotide TFA is an angiopoietin-1 mimetic that functions as a Tie-2 activator, leading to Tie-2 phosphorylation. This compound exhibits anti-inflammatory and anti-permeability effects, making it relevant for various research applications.
- Ameliorates endotoxin-induced endothelial barrier dysfunction
- Promotes angiogenesis in a mouse model of diabetic ulcer
- Protects mice from vascular leakage
- Reduces mortality in murine abdominal sepsis
- Decreases microvascular leakage
- Improves microcirculatory perfusion in a rat model of hemorrhagic shock
Medchemexpress LLC Ribupatide (TFA) | 2940971-65-1 | 98.74% | 4907.48 | 5 MG
Ribupatide (TFA) is a dual gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) receptor agonist. This compound is used in antidiabetic research and is for research use only. It is orally active and can also be administered by injection.
- Dual GIP and GLP-1 receptor agonist
- Orally active
- Can be administered by injection
- Suitable for antidiabetic research
Medchemexpress LLC TFLLR-NH2(TFA) | 1313730-19-6 | 99.6% | 761.83 | 10 MG
TFLLR-NH2(TFA) is a selective PAR1 agonist with an EC50 of 1.9 μM, intended for research use. It stimulates concentration-dependent increases in intracellular calcium and promotes upregulation of E-cadherin expression in SW620 cells. In vivo, it can induce oedema and extravasation in various organs.
- Selective PAR1 agonist (EC50 of 1.9 μM)
- Induces concentration-dependent increases in intracellular calcium
- Upregulates E-cadherin expression in SW620 cells
- Stimulates secreted TGF-β1 in platelet cultures
- Can induce oedema and extravasation in animal models
- Stable for 2 years as powder at -80°C
- Stable for 6 months in solvent at -80°C
Medchemexpress LLC Galantide TFA | 98.1% | 2313.55 | 5 MG
Galantide TFA from MedChemExpress is a synthetic peptide, identified by its chemical structure L-Methioninamide, glycyl-L-tryptophyl-L-threonyl-L-leucyl-L-asparaginyl-L-seryl-L-alanylglycyl-L-tyrosyl-L-leucyl-L-leucylglycyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanyl-glycyl-L-leucyl- (TFA). This compound, with a molecular weight of 2313.55, is provided as a white to off-white solid with a purity of 98.09% as determined by LCMS.
- High purity of 98.09%
- White to off-white solid appearance
- Recommended storage at -80°C for up to 2 years in powder form
Medchemexpress LLC MI-1061 TFA | 1410737-35-7 | 97.5% | 696.47 | C32H27Cl2F4N3O6 | 10MM 1ML
MI-1061 TFA is the trifluoroacetate salt of MI-1061, a potent, orally bioavailable inhibitor of the MDM2-p53 interaction (reported IC50 = 4.4 nM; Ki = 0.16 nM). The compound is offered as a solid and as a ready-to-use 10 mM solution in DMSO (1 mL) for in vitro assays, and the manufacturer provides solubility and in vivo formulation guidance. Typical uses include biochemical and cell-based studies of p53 pathway modulation.
- Potent MDM2-p53 interaction inhibitor (IC50 4.4 nM).
- Available as solid and as a 10 mM solution in DMSO for immediate use.
- High purity (approximately 97.5%), suitable for research assays.
- Soluble in DMSO (reported solubility 120 mg/mL), enabling concentrated stocks.
- Manufacturer provides recommended stock concentrations and in vivo vehicle guidance.
Medchemexpress LLC TP-5801 (TFA) | 99.6% | 641.48 | 50 MG
TP-5801 TFA is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor with an IC50 of 1.40 nM. It demonstrates significant anti-tumor activity both in vitro and in vivo. This compound is stable under recommended storage conditions and is for research use only.
- Inhibits TNK1-driven, BCR-ABL-driven, and IL-3-driven Ba/F3 cell growth
- Inhibits TNK1-dependent L540 cell growth at low nanomolar levels
- Shows efficacy in mouse survival models with no observed toxicity
- Reduces localized tumor growth and phospho-STAT3 in xenograft models
Medchemexpress LLC RI(dl)-2 TFA | 98.0% | 1 ML
RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC50 of 11.1 μM. It inhibits homologous recombination (HR) activity in human cells with an IC50 of 3.0 μM and does not influence RAD51 binding to ssDNA.
- Potent and selective RAD51-mediated D-loop formation inhibitor
- IC50 of 11.1 μM for D-loop formation
- Inhibits homologous recombination (HR) activity in human cells
- Does not influence RAD51 binding to ssDNA
- Stabilizes nucleoprotein filaments in a nonfunctional state
- Shielded from pathways promoting single-strand annealing
Medchemexpress LLC Glycyl-Exatecan TFA | 1883333-57-0 | 96.9% | 1 MG
Glycyl-Exatecan TFA is an anticancer agent derived from Exatecan. It exhibits significant antitumor activity and is suitable for research on cancers such as solid tumors.
- Anticancer agent
- Derivative of Exatecan
- Exhibits significant antitumor activity
- Utilized in research for various cancers, including solid tumors
- Store at -20°C, protected from light and under nitrogen
Medchemexpress LLC SETD2-IN-1 (TFA) | 2411759-92-5 | 97.2% | 514.51 | 100 MG
EZM0414 TFA is the TFA salt form of EZM0414. It is a potent, selective, and orally active inhibitor of SETD2, with an IC50 of 18 nM in a biochemical assay and 34 nM in a cellular assay. This product is intended for research related to relapsed or refractory multiple myeloma and diffuse large B-cell lymphoma.
- Potent, selective, and orally active inhibitor of SETD2.
- Inhibits proliferation of multiple myeloma and diffuse large B-cell lymphoma cell lines.
- Demonstrated robust tumor growth regressions in xenograft models.
- Correlated with reductions in intratumoral H3K36me3 levels.
- Well-tolerated in animal models.
- Exhibits high oral bioavailability in rats and mice.
eMolecules 76045-93-7 | 2,2,2-Trifluoroacetic acid- 2-bromoethyl ester | Oakwood Chemical | MFCD28396350 | 220.973 | C4H4BrF3O2 | 98.000 | FC(F)(F)C(=O)OCCBr | 1g | 537706582
2,2,2-Trifluoroacetic acid- 2-bromoethyl ester | Oakwood Chemical | 76045-93-7 | MFCD28396350 | 220.973 | C4H4BrF3O2 | 98.000 | FC(F)(F)C(=O)OCCBr | 1g | 537706582
Medchemexpress LLC Relamorelin (TFA) | 2863659-22-5 | 99.8% | 905.00 | 25 MG
Relamorelin TFA is a pentapeptide ghrelin analog and a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for the GHS-1a receptor. It is centrally penetrant, increases growth hormone levels, and accelerates gastric emptying. This compound has potential for research into cachexia, gastroparesis, and gastric/intestinal dysmobility disorders.
- Pentapeptide ghrelin analog
- Selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist
- Ki of 0.42 nM for GHS-1a receptor
- Centrally penetrant
- Increases growth hormone levels
- Accelerates gastric emptying
- Shows ~3 times greater affinity for GHS-1a (Ki=0.42 nM) than native ghrelin (Ki=1.12 nM)
- 6 times more potent (EC50=0.71 nM) in activating the GHS-1a receptor than native ghrelin (EC50=4.2 nM) in vitro by calcium mobilization
- Solid appearance, white to off-white color
- For research use only.
Medchemexpress LLC MtvkPabc-p5 TFA | 1190.22 | C54H74F3N11O16 | 5 MG
MTvkPABC-P5 TFA is a Toll-like receptor 7 (TLR7) agonist and immune stimulant used as a reagent for synthesizing immune-stimulating antibody conjugates (ISACs). It is supplied as the trifluoroacetic acid (TFA) salt in solid form. Molecular formula: C54H74F3N11O16; molecular weight: 1190.22.
- Acts as a TLR7 agonist and immune stimulant.
- Used to synthesize immune-stimulating antibody conjugates (ISACs).
- Supplied as the trifluoroacetic acid (TFA) salt in solid form.
- Storage: solid -20°C; protect from light; store under nitrogen.
- Available pack sizes: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.
Medchemexpress LLC 3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid | 909725-62-8 | 98.2% | 456.39 g/mol | C18H28F3N2O6P | 1 ML
W146 TFA is the trifluoroacetic acid salt of W146, a selective antagonist of the sphingosine-1-phosphate receptor 1 (S1PR1). It is supplied as a ready-to-use 10 mM solution in DMSO and as solid material for research applications, and is used in in vitro pharmacology and signaling studies to probe S1PR1-mediated pathways.
- Selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1).
- Reported EC50 of 398 nM.
- Supplied as 10 mM solution in DMSO (1 mL) and in multiple solid masses.
- Chemical identifiers: CAS 909725-62-8, formula C18H28F3N2O6P, MW 456.39 g/mol.
- Intended for research use only; not for human or clinical use.
TARGETMOL CHEMICALS INC LEVOROTATION NIMORAZOLE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Levorotation nimorazole phosphate ester TFA is an anti-anaerobic and anti-parasitic agent.