Choose the brand aligned with your industry so we can best serve your needs.
For researchers, scientists, and technical professionals: Your one-stop shop for the complete range of laboratory, production, and safety products and services.
Organic compounds that contain a carbon atom bonded to a halogen atom, and an oxygen atom via a double bond; commonly derived from an oxoacid by replacing a hydroxyl group with a halogen atom.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Mepenzolate bromide is an orally administered muscarinic receptor antagonist, with Kis of 0.68 and 2.6 nM for hM2R and hM3R, respectively. It can be used to suppress gastrointestinal hypermotility associated with irritable bowel syndrome, and is also identified as a GPR109A inhibitor.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
N3-Cho bromide (azido-choline bromide) is an azide-containing click chemistry reagent used to introduce an azido-choline moiety in the synthesis and labeling of cell membrane structures. It is supplied as a small research pack and is intended for use in chemical synthesis and biochemical labeling applications.
Contains an azide functional group for click chemistry conjugation.
Suitable for synthesis of membrane components and biochemical probes.
High purity (≈99.6%) for research applications.
Supplied as a 5 mg research pack for small-scale synthesis.
Store sealed at low temperature to minimize degradation.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Also available in 2mg 10mg 25mg 50mg 100mg 500mg and bulk. Please contact Fisher for quotes. KRN2 bromide is a potent selective inhibitor of nuclear factor of activated T cells (NFAT5 IC50= 0.1 μM). purity: 99%
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Aclidinium Bromide (CAS 320345-99-1) is a long-acting muscarinic antagonist (LAMA) that selectively inhibits muscarinic acetylcholine receptors In binding assays it demonstrates high affinity for M1 M5 receptor subtypes with Ki values of 0 10 0 21 nM Functional studies reveal greater potency at endogenous M2 and M3 receptors with EC50 values of 17 4 nM and 5 3 nM respectively In vivo aclidinium bromide produces a concentration-dependent inhibition of acetylcholine-induced bronchoconstriction (EC50 2 5 23 1 g/mL in anesthetized guinea pigs) and suppresses pilocarpine-induced salivation in rats (EC50 38 g/kg) This compound is widely utilized in respiratory research for evaluating airway smooth muscle modulation via muscarinic receptor antagonism
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Otilonium Bromide (CAS 26095-59-0) is an orally-administered muscarinic acetylcholine receptor (mAChR) antagonist exhibiting smooth muscle relaxation properties Its mechanism involves inhibition of calcium mobilization within intestinal smooth muscle cells lowering intracellular free calcium levels and thus attenuating muscle contractile activity In research settings Otilonium Bromide is commonly employed to investigate pathophysiological processes in irritable bowel syndrome (IBS) and dysfunctions associated with intestinal smooth muscle motility
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Tiotropium bromide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. It is a 24-hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease. It improves symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure.
Targets mAChR
Involved in GPCR/G Protein and neuronal signaling pathways
Long-acting, stops signaling between neurons and leads to muscle relaxation
Used in the management of chronic obstructive pulmonary disease
Improves symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Umeclidinium bromide (CAS 869113-09-7) is a potent and long-acting antagonist of muscarinic acetylcholine receptors (mAChRs) displaying high affinity for subtypes M1 M5 with Ki values of 0 16 nM 0 15 nM 0 06 nM 0 05 nM and 0 13 nM respectively It selectively targets mAChRs without observable activity at unrelated receptors or channels such as / opioid receptors sodium channels or dopamine transporters In cell-based assays using CHO cells expressing recombinant human mAChRs umeclidinium inhibits acetylcholine-induced calcium flux with pA2 values between 9 6 and 10 6 for M1 M3 receptors In murine models it reverses acetylcholine-driven bronchoconstriction Umeclidinium bromide is broadly applied in research focused on pulmonary disease mechanisms and drug development
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Umeclidinium bromide (CAS 869113-09-7) is a potent and long-acting antagonist of muscarinic acetylcholine receptors (mAChRs) displaying high affinity for subtypes M1 M5 with Ki values of 0 16 nM 0 15 nM 0 06 nM 0 05 nM and 0 13 nM respectively It selectively targets mAChRs without observable activity at unrelated receptors or channels such as / opioid receptors sodium channels or dopamine transporters In cell-based assays using CHO cells expressing recombinant human mAChRs umeclidinium inhibits acetylcholine-induced calcium flux with pA2 values between 9 6 and 10 6 for M1 M3 receptors In murine models it reverses acetylcholine-driven bronchoconstriction Umeclidinium bromide is broadly applied in research focused on pulmonary disease mechanisms and drug development
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Sepantronium bromide (YM-155) is a small-molecule survivin inhibitor used in research to suppress survivin expression and study apoptosis in cancer models. It shows potent activity in cellular assays and is supplied at high purity for biochemical and cell-based experiments.
Potent survivin inhibition (IC50 ~0.54 nM).
High purity: 98.9%.
Available as a solid or as a 10 mM solution for flexible dosing.
Chemical formula C20H19BrN4O3; mol wt 443.3 g/mol.
Intended for research use only.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More