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Organic compounds that contain a carbon atom bonded to a halogen atom, and an oxygen atom via a double bond; commonly derived from an oxoacid by replacing a hydroxyl group with a halogen atom.
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Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that exhibits anticancer effects. It functions by binding to FAK, thereby disrupting the interaction between FAK and p53.
Decreases cancer cell viability and clonogenicity in a p53-dependent manner.
Increases p53 transcriptional activity, which is inhibited by FAK, using p21, Mdm-2, and Bax-promoter targets.
Leads to increased expression of p53 targets: p21, Mdm-2, and Bax proteins.
Significantly reduces tumor growth, disrupts the FAK and p53 complex, and up-regulates p21 in HCT116 p53+/+ xenografts (not in HCT116 p53-/- xenografts).
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Propionyl-DL-carnitine chloride is a carnitine derivative used as a biochemical research reagent, notably in studies of inflammation and energy metabolism. It is provided as a white to off-white solid with high purity and defined storage recommendations to preserve stability.
High purity (98.1%).
White to off-white solid appearance.
Molecular weight 253.72 g/mol.
CAS number 18828-58-5.
Powder storage: -20°C for long-term stability.
Suitable for biochemical and inflammation research applications.
Available in multiple research-scale quantities including 100 mg.
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N-(Chloroacetyl)-2-methoxybenzamide is a drug intermediate used for the synthesis of various active compounds. It is intended for research use only and is not sold to patients.
Drug intermediate
Intended for research use only
Not sold to patients
Solid appearance
Shipped at room temperature in continental US (may vary elsewhere)
Storage as powder: -20°C for 3 years, 4°C for 2 years
Storage in solvent: -80°C for 6 months, -20°C for 1 month
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Aclidinium Bromide (CAS 320345-99-1) is a long-acting muscarinic antagonist (LAMA) that selectively inhibits muscarinic acetylcholine receptors In binding assays it demonstrates high affinity for M1 M5 receptor subtypes with Ki values of 0 10 0 21 nM Functional studies reveal greater potency at endogenous M2 and M3 receptors with EC50 values of 17 4 nM and 5 3 nM respectively In vivo aclidinium bromide produces a concentration-dependent inhibition of acetylcholine-induced bronchoconstriction (EC50 2 5 23 1 g/mL in anesthetized guinea pigs) and suppresses pilocarpine-induced salivation in rats (EC50 38 g/kg) This compound is widely utilized in respiratory research for evaluating airway smooth muscle modulation via muscarinic receptor antagonism
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Propionyl-DL-carnitine chloride is a research-grade carnitine derivative supplied as a chloride salt for laboratory studies, including inflammation research. The compound is provided as a solid powder and must be handled and stored per safety and stability guidelines.
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