Acyl Halides
Medchemexpress LLC Otilonium (bromide) | 26095-59-0 | 99.7% | 1 ML
Otilonium bromide is an orally active mAChR inhibitor and smooth muscle relaxant. It can interfere with the mobilization of calcium in intestinal smooth muscle and is used for research on irritable bowel syndrome.
- Inhibits acetylcholine-induced human colonic crypt calcium signals in a dose-dependent manner with an IC50 of 880 nM.
- Inhibits Ca2+ uptake in bovine chromaffin cells at 30 μM.
- Targets mAChR and is involved in GPCR/G Protein and Neuronal Signaling pathways.
Medchemexpress LLC Cyanine 3.5 bromide | 98.6% | 734.72 g·mol⁻1 | C42H44BrN3O4 | 10 MG
Cyanine 3.5 bromide is a red reactive fluorescent dye used for covalent labeling of primary amines on peptides, proteins, and oligonucleotides for fluorescence imaging and detection. It exhibits red fluorescence with excitation near 591 nm and emission near 604 nm, and is typically supplied as a small research-scale powdered quantity.
- Reactive NHS ester for covalent labeling of primary amines.
- Red fluorescence with typical excitation ~591 nm and emission ~604 nm.
- Molecular formula C42H44BrN3O4, molecular weight 734.72 g·mol-1.
- Purity reported around 98.6%.
- Supplied as a 10 mg powder; store at -20 °C and protect from light.
- Suitable for labeling peptides, proteins, and oligonucleotides in imaging applications.
- Stable in common organic solvents; handle with appropriate safety precautions.
Apexbio Technology LLC Otilonium Bromide 26095-59-0 10mM (in 1mL DMSO)
Otilonium Bromide (CAS 26095-59-0) is an orally-administered muscarinic acetylcholine receptor (mAChR) antagonist exhibiting smooth muscle relaxation properties Its mechanism involves inhibition of calcium mobilization within intestinal smooth muscle cells lowering intracellular free calcium levels and thus attenuating muscle contractile activity In research settings Otilonium Bromide is commonly employed to investigate pathophysiological processes in irritable bowel syndrome (IBS) and dysfunctions associated with intestinal smooth muscle motility
Apexbio Technology LLC Tiotropium Bromide 136310-93-5 10mM (in 1mL DMSO)
Tiotropium Bromide (CAS 136310-93-5) is a potent antagonist of muscarinic acetylcholine receptors (mAChRs) By competitively inhibiting acetylcholine binding at these receptors it prevents receptor activation and subsequent signaling cascades leading to decreased neuronal transmission and smooth muscle relaxation As a long-acting anticholinergic bronchodilator with activity lasting approximately 24 hours Tiotropium Bromide is widely studied in managing chronic obstructive pulmonary disease (COPD) including cases complicated by chronic heart failure
Medchemexpress LLC Umeclidinium (bromide) | 869113-09-7 | 508.49 | 5 G
Umeclidinium bromide is a novel muscarinic acetylcholine receptor (mAChR) antagonist. It exhibits high affinity for human M1-M5 mAChRs, with Ki values ranging from 0.05 to 0.16 nM. This compound demonstrates antagonist activity at the human cloned muscarinic M3 receptor and inhibits the human ether-a-go-go-related gene (hERG) channel tail current.
- Targets mAChR1 and mAChR5.
- Inhibits acetylcholine-induced calcium mobilization in CHO cells.
- Demonstrates slow functional reversibility at M3 mAChRs.
- Inhibits human ether-a-go-go-related gene channel tail current.
Medchemexpress LLC 1,3,5-Tri-O-benzoyl-a-D-ribofuranose | 22224-41-5 | 99.8% | 462.45 | 5 G
1,3,5-Tri-O-benzoyl-a-D-ribofuranose is a purine nucleoside analog that exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve inhibiting DNA synthesis and inducing apoptosis, among other processes.
- Purine nucleoside analog
- Exhibits broad antitumor activity
- Targets indolent lymphoid malignancies
- Inhibits DNA synthesis
- Induces apoptosis
- Useful for cancer research
Medchemexpress LLC N6-benzoyl-2'-deoxyadenosine monohydrate | 305808-19-9 | MFCD00149575 | >98.0% | 373.4 g/mol | C17H19N5O5 | 5 G
N6-Benzoyl-2'-deoxyadenosine monohydrate is a nucleoside analog of deoxyadenosine bearing an N6-benzoyl protecting group. It is provided as a monohydrate solid for research use (CAS 305808-19-9) with purity ≥98.0%, and is used as an intermediate in nucleoside chemistry, oligonucleotide synthesis, and studies of nucleoside analog activity.
- High purity suitable for research applications.
- Monohydrate solid form for stable handling and storage.
- Serves as an intermediate in nucleoside and oligonucleotide synthesis.
- Compatible with standard analytical and synthetic workflows.
- Supplied in small-scale laboratory pack sizes for bench use.
Medchemexpress LLC Oleyl bromide ((Z)-1-Bromooctadec-9-ene) | 6110-53-8 | 98.4% | 331.37 | 25 MG
Oleyl bromide is a hydrophobic compound that can carry out ring-opening reaction through a process called 'encapsulation.' It can also be used as the starting material in the synthesis of oleylphosphonates.
- Hydrophobic compound
- Can carry out ring-opening reactions
- Used as starting material in synthesis of oleylphosphonates
- For research use only
- Biochemical assay reagent
Medchemexpress LLC Tiotropium bromide | 136310-93-5 | 472.42 | 1 ML
Tiotropium bromide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. It is a 24-hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease. It improves symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure.
- Targets mAChR
- Involved in GPCR/G Protein and neuronal signaling pathways
- Long-acting, stops signaling between neurons and leads to muscle relaxation
- Used in the management of chronic obstructive pulmonary disease
- Improves symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure
Medchemexpress LLC N4-Benzoyl-2 -O-meth 10mM 1mL
N4-Benzoyl-2 -O-methylcytidine is a natural cytidine nucleoside analog Cytidine analogs have the mechanism of inhibiting DNA methyltransferase (such as Zebularine (HY-13420)) and have potential antimetabolite and antitumor activities[1][2]
Sigma Aldrich Fine Chemicals Biosciences Ipratropium bromide Relate5MG
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
eMolecules 1076199-21-7 | Ambeed | tert-Butyl (2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)ethyl)carbamate | 100mg | 552573626 | A138365 | MFCD09840081 | 356.257 | C13H26BrNO5
Ambeed | 2-Amino-3-bromobenzonitrile | 1g | 552746008 | A597346 | 114344-60-4 | MFCD05670539 | 197.035 | C7H5BrN2
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Apexbio Technology LLC Umeclidinium bromide 869113-09-7 5mg
Umeclidinium bromide (CAS 869113-09-7) is a potent and long-acting antagonist of muscarinic acetylcholine receptors (mAChRs) displaying high affinity for subtypes M1 M5 with Ki values of 0 16 nM 0 15 nM 0 06 nM 0 05 nM and 0 13 nM respectively It selectively targets mAChRs without observable activity at unrelated receptors or channels such as / opioid receptors sodium channels or dopamine transporters In cell-based assays using CHO cells expressing recombinant human mAChRs umeclidinium inhibits acetylcholine-induced calcium flux with pA2 values between 9 6 and 10 6 for M1 M3 receptors In murine models it reverses acetylcholine-driven bronchoconstriction Umeclidinium bromide is broadly applied in research focused on pulmonary disease mechanisms and drug development
Apexbio Technology LLC Umeclidinium bromide 869113-09-7 10mg
Umeclidinium bromide (CAS 869113-09-7) is a potent and long-acting antagonist of muscarinic acetylcholine receptors (mAChRs) displaying high affinity for subtypes M1 M5 with Ki values of 0 16 nM 0 15 nM 0 06 nM 0 05 nM and 0 13 nM respectively It selectively targets mAChRs without observable activity at unrelated receptors or channels such as / opioid receptors sodium channels or dopamine transporters In cell-based assays using CHO cells expressing recombinant human mAChRs umeclidinium inhibits acetylcholine-induced calcium flux with pA2 values between 9 6 and 10 6 for M1 M3 receptors In murine models it reverses acetylcholine-driven bronchoconstriction Umeclidinium bromide is broadly applied in research focused on pulmonary disease mechanisms and drug development
Medchemexpress LLC Sepantronium bromide | 781661-94-7 | MFCD11983133 | 98.9% | 443.3 g/mol | C20H19BrN4O3 | 100 MG
Sepantronium bromide (YM-155) is a small-molecule survivin inhibitor used in research to suppress survivin expression and study apoptosis in cancer models. It shows potent activity in cellular assays and is supplied at high purity for biochemical and cell-based experiments.
- Potent survivin inhibition (IC50 ~0.54 nM).
- High purity: 98.9%.
- Available as a solid or as a 10 mM solution for flexible dosing.
- Chemical formula C20H19BrN4O3; mol wt 443.3 g/mol.
- Intended for research use only.