Benzenoids
Medchemexpress LLC A 779 | 159432-28-7 | 99.3% | 872.97 | 100 MG
A 779 is a specific antagonist of the G-protein coupled receptor (Mas receptor), which is an Ang1-7 receptor distinct from the classical AngII. It is for research use only.
- Inhibits the effect of Ang-(1-7)
- Suppresses PCNA protein expression up-regulated by Ang II
- Blocks Ang II-induced inflammatory responses of VSMCs
- Blocks Ang II-induced Akt and ERK1/2 phosphorylation
- Elevates serum BALP, CTX, TRAcP 5b, OC, and urinary DPD
- Abolishes Ang-(1-7)'s favorable effects on bone health by blocking the Mas receptor
- Erradicates captopril protective effects on bone metabolism, mineralization, and micro-structure
- Restores OVX effects on RANKL expression and ACE-1/AngII/AT1R cascade
- Down-regulates OPG expression and ACE-2/Ang1-7/Mas pathway
![Medchemexpress LLC 4H-1-Benzopyran-4-one, 3-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy- | 102067-84-5 | 99.9% | 284.26 | 10 MM 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000437343-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 4H-1-Benzopyran-4-one, 3-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy- | 102067-84-5 | 99.9% | 284.26 | 10 MM 1 ML
Sappanone A is an orally active homoisoflavone found in sappan L. It acts as a PDE4 and NF-κB inhibitor, demonstrating anti-inflammatory and antioxidant effects. This compound induces HO-1 expression through activation of the Nrf2 pathway and inhibits RANKL-induced osteoclastogenesis, making it a promising agent for research in inflammation-related and cardiovascular conditions.
- Inhibits PDE4 and NF-κB
- Exhibits anti-inflammatory and antioxidant properties
- Induces HO-1 expression via Nrf2 pathway
- Inhibits RANKL-induced osteoclastogenesis
- Suitable for research on inflammation-related and cardiovascular conditions
Enzo Life Sciences L-Thiocitrulline . dihydrochloride (50mg). CAS: 212051-53-1
Inhibitor of neuronal (nNOS; NOS I; Ki=60nM) and inducible (iNOS; NOS II) nitric oxide synthase. Formula: C6H13N3O2S . 2HCl. MW: 191.3 . 72.9. Purity: ≥97% (TLC). Appearance: White solid. Solubility: Soluble in water or DMSO. Long Term Storage: +4°C.
Apexbio Technology LLC HyperTrap Q FF Column 5ml
The HyperTrap Q FF Column is not a small molecule but a chromatography medium designed for the purification of biomolecules particularly proteins and nucleic acids It operates via strong anion exchange chromatography utilizing quaternary ammonium functional groups immobilized on a Fast Flow resin matrix to selectively bind negatively charged molecules under defined buffer conditions This allows for efficient separation and recovery of target biomolecules from complex mixtures The HyperTrap Q FF Column is applied in research settings for desalting buffer exchange and isolation of nucleic acids or proteins supporting downstream analyses and preparative workflows in the biomedical field
Selleck Chemical LLC IQ-1
IQ-1 enables Wnt/ -catenin-driven expansion of mouse ESCs and prevents spontaneous differentiation Maintains embryonic stem cell (ESC) pluripotency in Wnt3a-treated cells and prevents PP2A/Nkd interaction
Medchemexpress LLC Cabozantinib | Purity: 99.96 | Mol wt: 501.51 | 849217-68-1 | 200mg
Cabozantinib | Purity: 99.96 | Mol wt: 501.51 | 849217-68-1 | 200mg
Medchemexpress LLC Tetra-O-benzyl-δ-D-gluconolactone | 13096-62-3 | 538.63 | 10 G
Tetra-O-benzyl-δ-D-Gluconolactone is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is for research use only.
- Can be used as a biological material for life science research
- Can be used as an organic compound for life science research
- Appears as a colorless to light yellow viscous liquid
Matrix Scientific 4-BROMO-2,3-DIFLUOROPHENOL-5G
4-Bromo-2,3-difluorophenol, 97%; 5g,C6H3BrF2O, MFCD08061907, mw 209.00, [144292-32-0]
Medchemexpress LLC NY-ESO-1 (157-165) peptide TFA | 97.6% | 1208.37 | 10 MG
NY-ESO-1 (157-165) peptide (TFA) is a peptide fragment from the NY-ESO-1 protein. It can activate the immune system, particularly in HLA-A2 positive individuals, by being recognized by CD8+ T cells, thereby triggering an immune response. This peptide is expressed in various tumors and can be utilized as a target for tumor immunotherapy.
- Peptide fragment from NY-ESO-1 protein
- Activates the immune system in HLA-A2 positive individuals
- Recognized by CD8+ T cells, triggering an immune response
- Expressed in various tumors
- Can be used as a target for tumor immunotherapy
- Highly immunogenic epitope of NY-ESO-1
- Can induce spontaneous or vaccine-induced T cell immune responses
Medchemexpress LLC Benzaldehyde, 3-fluoro-4-methoxy- | 351-54-2 | 154.14 | 10 G
3-Fluoro-4-methoxybenzaldehyde is a drug intermediate used in the synthesis of fluorinated derivatives of Combretastatin A-4, which possesses anti-cancer activity. It has a molecular weight of 154.14 and a purity of 99.9% by GC.
- Used to synthesize fluorinated derivatives of Combretastatin A-4
- Demonstrates anti-cancer activity
- Molecular formula: C8H7FO2
- Appearance: Light yellow to yellow liquid
Medchemexpress LLC Hypidone hydrochloride | 1339058-04-6 | 99.7% | 334.84 g/mol | C18H23ClN2O2 | 100 MG
Hypidone hydrochloride is the hydrochloride salt of a research compound with potent serotonergic activity. It functions as a selective serotonin (5-HT) uptake inhibitor and a 5-HT1A receptor agonist, and has demonstrated oral activity in animal models of depression. Supplied as a powder for laboratory research use only; not for human or clinical use.
- High purity suitable for research applications.
- Dual mechanism: serotonin uptake inhibition and 5-HT1A receptor agonism.
- Demonstrated oral activity in animal depression models.
- Available in multiple pack sizes including small research quantities.
- Recommended sealed storage away from moisture; in solvent store at -80°C for long term.
Apexbio Technology LLC Ac-IETD-pNA 219138-21-3 25mg
Ac-IETD-pNA (CAS 219138-21-3) is a synthetic peptide substrate designed for colorimetric detection of caspase-8 activity as well as related cysteine proteases such as caspase-6 caspase-10 and granzyme B The IETD sequence within Ac-IETD-pNA corresponds to the canonical cleavage site recognized by caspase-8 enabling specific substrate hydrolysis during apoptosis Upon enzymatic cleavage p-nitroaniline (pNA) is released and quantified spectrophotometrically at 405 nm providing a direct measure of protease activity in cell lysates This compound is widely employed for the identification and quantification of caspase-8 activation and facilitates the study of downstream apoptotic signaling pathways in biomedical research