Benzenoids
Medchemexpress LLC GDC-0339 | 1428569-85-0 | 99.9% | 465.50 | 100 MG
GDC-0339 is a potent, orally bioavailable, and well-tolerated pan-Pim kinase inhibitor, with Kis of 0.03 nM, 0.1 nM, and 0.02 nM for Pim1, Pim2, and Pim3, respectively. It is being explored as a potential treatment for multiple myeloma.
- Potent, orally bioavailable, and well-tolerated pan-Pim kinase inhibitor.
- Discovered as a potential treatment for multiple myeloma.
- Cytostatic with an IC50 of 0.1 μM for MM.1S cells.
- Induces a constellation of Pim downstream signaling events consistent with inhibition of Pim kinases.
- Efficacious in RPMI8226 and MM.1S human multiple myeloma xenograft mouse models.
Medchemexpress LLC Saxagliptin (hydrochloride) | 709031-78-7 | 99.71% | 351.87 | 1 ML
Saxagliptin hydrochloride is a potent, selective, reversible, competitive, and orally active dipeptidyl peptidase-4 (DPP-4) inhibitor. It has the potential for research in type 2 diabetes mellitus.
- It acts by preventing the degradation of glucagon-like peptide-1, which increases insulin secretion and decreases glucagon secretion.
- Studies have shown that saxagliptin can induce β-cell proliferation.
- It has been observed to increase p-AKT and active β-catenin protein levels, alongside increased c-myc and cyclin D1 protein expression.
- It dose-dependently inhibits plasma DPP-4 activity.
Medchemexpress LLC Agrin Human CHO H 100ug | 100ug
Agrin is critical for neuromuscular junction development and was discovered in mouse knockout studies It contains laminin G Kazal-type serpin and epidermal growth factor domains Agrin Protein Human (CHO His) is the recombinant human-derived Agrin protein expressed by CHO with N-6 His labeled tag
AdipoGen Glimepiride (250 mg)
Chemical. CAS: 93479-97-1. Formula: C24H34N4O5S. MW: 490.62. Glimepiride is a long-acting sulfonylurea antidiabetic agent inhibiting ATP-sensitive potassium (KATP) channels in pancreatic beta-cells, which leads to the release of insulin. In addition, Glimepiride increases the activity of intracellular insulin receptors. Studies conducted on adipocytes and skeletal muscle suggest that Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase and stimulates glucose transporter 1 and 4 (GLUT1/4) expression. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway and exhibits neuroprotective benefit, decreasing expression and activity of BACE1 and amyloid-beta (Abeta) in neurons in a PPARgamma-dependent manner.
Medchemexpress LLC GM-CSF Pig 5ug | 5ug
The GM-CSF protein acts as a potent cytokine that coordinates the growth and differentiation of hematopoietic precursor cells of different lineages including granulocytes macrophages eosinophils and erythrocytes Structurally GM-CSF exists as a monomer and its signaling is mediated through a dodecamer complex GM-CSF Protein Pig is the recombinant Porcine-derived GM-CSF protein expressed by E coli with tag free
Strem, An Ascensus Company CAS# 462-06-6. 25g. Fluorobenzene, 99%. MFCD00000280
CAS# 462-06-6. 25g. Fluorobenzene, 99%. MFCD00000280. Molecular Weight: 96.10. Molecular Formula: C6H5F. Color/form: colorless liq. Strem# 09-3480. http://www.strem.com/catalog/v/09-3480/
Aobchem 2-Bromo-4-(trifluoromethl)benzoic acid, AOBCHEM USA 15559-5G. 328-89-2. MFCD07368837
2-Bromo-4-(trifluoromethl)benzoic acid, AOBCHEM USA 15559-5G. 328-89-2. MFCD07368837
Medchemexpress LLC Acetic acid, 2-bromo-, 2,5-dioxo-1-pyrrolidinyl ester | 42014-51-7 | 99.2% | 236.02 | 1 G
N-Succinimidyl bromoacetate is a heterobifunctional cross-linking reagent that can be used to prepare peptide-protein immunogens.
- Acts as a heterobifunctional cross-linking reagent.
- Used to prepare peptide-protein immunogens.
Selleck Chemical LLC BI-0474-E1356-25MG
BI-0474 is a potent inhibitor of KRASG12C with an IC50 value of 7 0 nM It inhibits GDP-KRAS SOS1 protein-protein interactions It exhibits anti-proliferative and anti-tumour activity and can be used in cancer research