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Organic compounds that are derived from or have a benzene group in their molecular structure. Benzene is an aromatic organic molecule composed of 6 carbon atoms and 6 hydrogen atoms that form a ring. Includes derivatives and substituted molecules.
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kb NB 142-70 (CAS 1233533-04-4) is a small molecule inhibitor that exhibits selectivity toward protein kinase D (PKD) isoforms with reported IC50 values of 28 3 nM for PKD1 58 7 nM for PKD2 and 53 2 nM for PKD3 By targeting PKD activity kb NB 142-70 has been shown to suppress prostate cancer cell migration and invasion as well as impair wound healing processes in vitro Additionally it demonstrates pronounced cytotoxic and anti-proliferative properties in cellular assays This compound is utilized in research to investigate PKD-related signaling pathways and to explore therapeutic strategies targeting cancer cell proliferation and metastatic behavior
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(+)-SHIN1 ((+)-RZ-2994) is an active (+) enantiomer of SHIN1. It is potent against cytosolic SHMT1 with an IC50 for blocking growth of less than 50 nM and 870 nM in SHMT2 deletion cells and HCT-116 cells, respectively. It is for research use only.
Active (+) enantiomer of SHIN1.
Potent against cytosolic SHMT1.
For research use only.
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8-CPT-Cyclic AMP sodium is a selective activator of cyclic AMP-dependent protein kinase (PKA). It is also a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA) with an IC50 of 0.9 μM, and it inhibits PDE III and PDE IV with IC50Epac, functioning as a potent Epac activator.
Delays TNF-α/CHX-induced and α-Fas-induced apoptosis in neutrophils.
More effective against apoptosis induced by TNF-α/CHX than by α-Fas.
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Bis-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins by containing two different ligands connected by a linker; one for an E3 ubiquitin ligase and the other for the target protein. It is for research use only.
PEG-based PROTAC linker
Used in the synthesis of PROTACs
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HRP Anti-Flag Tag Mouse Monoclonal Antibody is a monoclonal antibody targeting the Flag epitope (DYKDDDDK) a widely used fusion tag in recombinant protein studies Conjugated to horseradish peroxidase (HRP) this antibody enables direct detection and visualization of Flag-tagged proteins via colorimetric or chemiluminescent assays HRP Anti-Flag Tag Mouse Monoclonal Antibody exerts its biological activity primarily by specifically binding to the Flag tag sequence allowing selective recognition of Flag-tagged proteins in samples from various species Based on these properties HRP Anti-Flag Tag Mouse Monoclonal Antibody holds research potential in applications such as Western blotting (WB) immunocytochemistry (ICC) and enzyme-linked immunosorbent assay (ELISA)
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