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Organic compounds that consists entirely of hydrogen and carbon elements usually organized in a chain; some may have a cyclic structure. Includes hydrocarbons that have additional functional groups such as aromatic rings.
ML162-yne (CAS No 2883115-46-4) is a compound predominantly used in biomedical research as a kinase inhibitor Originating in specialized laboratories focused on signal transduction pathways ML162-yne acts by targeting specific kinases involved in cellular signaling thereby modulating critical biochemical pathways Its in vitro activity is observed in the nanomolar to low micromolar range making it a potent agent for studies investigating kinase-mediated processes Researchers commonly utilize ML162-yne in both cellular and animal models to elucidate its effect on cell proliferation apoptosis and other vital cellular functions This compound is frequently used in drug screening assays to discover and optimize new therapeutic agents targeting kinase pathways Experimental concentrations of ML162-yne typically depend on the specific research design allowing flexibility in its application across various investigational contexts
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ML162-yne (CAS No 2883115-46-4) is a compound predominantly used in biomedical research as a kinase inhibitor Originating in specialized laboratories focused on signal transduction pathways ML162-yne acts by targeting specific kinases involved in cellular signaling thereby modulating critical biochemical pathways Its in vitro activity is observed in the nanomolar to low micromolar range making it a potent agent for studies investigating kinase-mediated processes Researchers commonly utilize ML162-yne in both cellular and animal models to elucidate its effect on cell proliferation apoptosis and other vital cellular functions This compound is frequently used in drug screening assays to discover and optimize new therapeutic agents targeting kinase pathways Experimental concentrations of ML162-yne typically depend on the specific research design allowing flexibility in its application across various investigational contexts
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ML162-yne is a potent GPX4-inhibitor affinity probe and a click chemistry reagent. It contains an Alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Potent GPX4-inhibitor affinity probe
Click chemistry reagent
Contains an Alkyne group for CuAAc reactions
High purity: 99.06%
Molecular weight: 501.42
Appearance: Solid, white to off-white
Soluble in DMSO (100 mg/mL)
Targets GPX4
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CAS# 12289-94-0. 5G. Bis(2-methylallyl)(1,5-cyclooctadiene)ruthenium(II), min. 97%. MFCD00216965. Molecular Formula: (C4H7)2(C8H12)Ru. Molecular Weight: 319.45. Color/Form: tan to brown pwdr. Stability: store cold (-18°C). Strem# 44-0046. www.strem.com/catalog/v3/44-0046/
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ML162-yne is a potent GPX4-inhibitor affinity probe and a click chemistry reagent. It contains an alkyne group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing azide groups.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
VE-821 is a potent ATP-competitive inhibitor of ATR with a Ki/IC50 of 13 nM/26 nM. It exhibits excellent selectivity for ATR with minimal cross-reactivity against related PIKKs. This compound significantly enhances the sensitivity of pancreatic cancer cells to radiation and Gemcitabine, making it suitable for studies on DNA damage response and cancer therapy.
Potent ATP-competitive inhibitor of ATR.
Exhibits excellent selectivity for ATR.
Enhances sensitivity of pancreatic cancer cells to radiation and Gemcitabine.
Inhibits radiation-induced G2/M arrest in cancer cells.
Soluble in DMSO (50 mg/mL).
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