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Organic compounds with acidic properties, and will commonly have carboxylic acids or similar functional groups in their structure. Derived compounds are also included.
Agmatine sulfate (CAS 2482-00-0) is an endogenously produced guanidine compound recognized for its interaction with multiple molecular targets It functions as an endogenous agonist at imidazoline receptors and acts as an inhibitor of nitric oxide synthase (NOS) Additionally agmatine modulates the activity of various ion channels and influences several neurotransmitter signaling pathways These multifaceted mechanisms have established agmatine sulfate as a valuable tool in studies related to neurobiology pain modulation neurodegenerative disorders and nitric oxide-mediated physiological processes
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Phenelzine sulfate (CAS 156-51-4) is a small-molecule inhibitor of monoamine oxidase (MAO) targeting both MAO-A and MAO-B isoforms By blocking MAO activity phenelzine sulfate limits the enzymatic degradation of monoamine neurotransmitters including norepinephrine serotonin and dopamine resulting in elevated synaptic levels This modulation of neurotransmitter availability underpins its utility in neuropharmacological research on mood regulation neurochemical signaling and mechanistic studies of neurotransmitter dynamics Phenelzine sulfate is commonly utilized to investigate the molecular and cellular effects of altered monoaminergic transmission in neuroscience and psychiatric research models
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Demethylasterriquinone B1 (CAS 78860-34-1) is a selective insulin receptor (IR) agonist that acts by promoting tyrosine phosphorylation within the insulin receptor -subunit This phosphorylation event subsequently activates downstream signaling pathways particularly phosphatidylinositol 3-kinase (PI3K) and AKT Demethylasterriquinone B1 has utility as a research tool for investigating insulin signaling cascades glucose metabolism and related metabolic regulatory mechanisms thus facilitating studies aimed at understanding insulin sensitivity and metabolic diseases
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Bafilomycin B1 is a macrolide antibiotic isolated from the mycelium of Streptomyces gresuis. It is a structural analog of Bafilomycin A1 and functions as an inhibitor of V-ATPase. This compound has demonstrated neuroprotective properties against Chloroquine-induced cell death. Furthermore, Bafilomycin B1 significantly inhibits the accumulation of lipid droplets induced by oxidized low-density lipoprotein (LDL).
Macrolide antibiotic: derived from Streptomyces gresuis mycelium.
V-ATPase inhibitor: acts as an inhibitor of V-ATPase, a key enzyme involved in various cellular processes.
Neuroprotective effects: provides neuroprotection against Chloroquine-induced neuronal death.
Lipid accumulation inhibition: significantly reduces the accumulation of lipid droplets induced by oxidized LDL.
Structural analog: shares structural similarities with Bafilomycin A1.
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Carboxypeptidase B1/CPB1 protein is part of the PDGF/VEGF growth factor family and has the same structural and functional characteristics as proteins that affect cell growth proliferation and angiogenesis This family is critical for mediating endothelial cell responses and promoting blood vessel formation including VEGF-C which is involved in lymphangiogenesis Carboxypeptidase B1/CPB1 Protein Mouse (HEK293 His) is the recombinant mouse-derived Carboxypeptidase B1/CPB1 protein expressed by HEK293 with C-His labeled tag
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Procyanidin B1 is a polyphenolic flavonoid isolated from commonly eaten fruits. It binds to the TLR4/MD-2 complex and exhibits anti-inflammatory activity. It is for research use only.
Polyphenolic flavonoid isolated from fruits and fruit juices
Binds to TLR4/MD-2 complex
Possesses anti-inflammatory activity
Causes cellular toxicity at concentrations >100 μg/mL
Inhibits LPS-induced TNF-α production and expression of MD-2, TRAF6, NF-κB mRNA, phosphorylated p38 MAPK, and NF-κB protein in THP1 cells at 100 μg/mL
Protects against Aβ oligomer-induced neuronal death at 50-100 μM
Potently inhibits the activation of caspase-3 at 100 μM, caspase-8 at 30, 50, and 100 μM, and caspase-9 at 10, 30, 50, and 100 μM
Significantly and dose-dependently induces expression of ACO and CPT1 at 10, 20, 30 μM, with no obvious effect on mRNA expression of PPARα
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Ephrin-B1/EFNB1 proteins bind to Eph receptors on neighboring cells and promote bidirectional signaling in developing neurons blood vessels and epithelia It has high affinity for EPHB1/ELK also binds EPHB2 and EPHB3 and induces commissural axon/growth cone collapse Ephrin-B1/EFNB1 Protein Rat (HEK293 His) is the recombinant rat-derived Ephrin-B1/EFNB1 protein expressed by HEK293 with C-His labeled tag
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