Organoheterocyclic compounds
2-Chlorophenothiazine 98.0+%, TCI America™
CAS: 92-39-7 Molecular Formula: C12H8ClNS Molecular Weight (g/mol): 233.713 MDL Number: MFCD00005016 InChI Key: KFZGLJSYQXZIGP-UHFFFAOYSA-N Synonym: 2-chlorophenothiazine,10h-phenothiazine, 2-chloro,phenothiazine, 2-chloro,2-chlorothiodiphenylamine,wln: t c666 bm isj eg,2-chloro-phenothiazine,2-chloropheno-thiazine,acmc-209rfl,2-chlorophenothizine,dsstox_cid_31643 PubChem CID: 7088 IUPAC Name: 2-chloro-10H-phenothiazine SMILES: C1=CC=C2C(=C1)NC3=C(S2)C=CC(=C3)Cl
2,5-Diphenyloxazole 99.0+%, TCI America™
CAS: 92-71-7 Molecular Formula: C15H11NO Molecular Weight (g/mol): 221.26 MDL Number: MFCD00005306 InChI Key: CNRNYORZJGVOSY-UHFFFAOYSA-N Synonym: 2,5-diphenyloxazole,oxazole, 2,5-diphenyl,tritosol,2,5-diphenyl-oxazole,ppo scintillator,dpo scintillator,usaf ek-6775,ppo van,ppo,ppo scintillator van PubChem CID: 7105 IUPAC Name: 2,5-diphenyl-1,3-oxazole SMILES: O1C(=CN=C1C1=CC=CC=C1)C1=CC=CC=C1
5,5‴-Dihexyl-2,2':5',2″:5″,2‴-quaterthio 98+%, TCI America™
CAS: 132814-92-7 Molecular Formula: C28H34S4 Molecular Weight (g/mol): 498.82 MDL Number: MFCD21396218 InChI Key: KGJQHEPGNCWZRN-UHFFFAOYSA-N Synonym: alpha,omega-Dihexylquaterthiophene PubChem CID: 10720155 IUPAC Name: 2-hexyl-5-[5-[5-(5-hexylthiophen-2-yl)thiophen-2-yl]thiophen-2-yl]thiophene SMILES: CCCCCCC1=CC=C(S1)C2=CC=C(S2)C3=CC=C(S3)C4=CC=C(S4)CCCCCC
5-Nitro-2-furaldehyde Diacetate 97.0+%, TCI America™
CAS: 92-55-7 Molecular Formula: C9H9NO7 Molecular Weight (g/mol): 243.171 MDL Number: MFCD00003244 InChI Key: HSXKWKJCZNRMJO-UHFFFAOYSA-N Synonym: 5-nitro-2-furaldehyde diacetate,2-diacetoxymethyl-5-nitrofuran,5-nitro-2-furanmethanediol diacetate,5-nitrofurfural diacetate,5-nitrofurfurylidene diacetate,5-nitrofuran-2-yl methylene diacetate,nitrofuraldehyde diacetate,5-nitro-2-furfural diacetate,5-nitrofuraldehyde diacetate,5-nitro-2-furfuraldehyde diacetate PubChem CID: 7097 IUPAC Name: [acetyloxy-(5-nitrofuran-2-yl)methyl] acetate SMILES: CC(=O)OC(C1=CC=C(O1)[N+](=O)[O-])OC(=O)C
![3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride 98.0+%, TCI America™](https://assets.fishersci.com/TFS-Assets/CCG/Chemical-Structures/chemical-structure-cas-762240-92-6.jpg-250.jpg)
3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride 98.0+%, TCI America™
CAS: 762240-92-6 Molecular Formula: C6H8ClF3N4 Molecular Weight (g/mol): 228.603 MDL Number: MFCD09817638 InChI Key: AQCSCRYRCRORET-UHFFFAOYSA-N Synonym: 3-trifluoromethyl-5,6,7,8-tetrahydro-1,2,4 triazolo 4,3-a pyrazine hydrochloride,3-trifluoromethyl-5h,6h,7h,8h-1,2,4 triazolo 4,3-a pyrazine hydrochloride,3-trifluoromethyl-5,6,7,8-tetrahydro-1,2,4-triazolo 4,3-a pyrazine hydrochloride,3-trifluoromethyl-1,2,4-triazolo 4,3-a piperazine hydrochloride,3-trifluoromethyl-5,6,7,8-tetrahydro-1,2,4 triazolo 4,3-a pyrazine hcl,3-trifluoromethyl-5,6,7,8-tetrahydro-1,2,4-triazolo-4,3-a pyrazine hydrochloride,3-trifluoromethyl-5,6,7,8-tetrahydro 1,2,4 triazolo 4,3-a pyrazine hydrochloride,5,6,7,8-tetrahydro-3-trifluormethyl-4,3-a-1,2,4-triazolopyrazine hydrochloride,pubchem18203 PubChem CID: 11961371 IUPAC Name: 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine;hydrochloride SMILES: C1CN2C(=NN=C2C(F)(F)F)CN1.Cl
9-n-Octyl-2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)carbazole 97.0+%, TCI America™
CAS: 406726-92-9 Molecular Formula: C32H47B2NO4 Molecular Weight (g/mol): 531.351 MDL Number: MFCD23703114 InChI Key: XVVSDGVWSRLSDI-UHFFFAOYSA-N Synonym: 9-n-Octyl-9H-carbazole-2,7-diboronic Acid Bis(pinacol) Ester PubChem CID: 11318555 IUPAC Name: 9-octyl-2,7-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)carbazole SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC3=C(C=C2)C4=C(N3CCCCCCCC)C=C(C=C4)B5OC(C(O5)(C)C)(C)C
Apexbio Technology LLC Levodopa 59-92-7 200mg
Levodopa (59-92-7) is a small-molecule precursor of dopamine It modulates dopaminergic signaling pathways thereby influencing neurotransmission and associated neuronal functions Levodopa exerts its biological activity primarily through enzymatic decarboxylation by aromatic L-amino acid decarboxylase within dopaminergic neurons yielding dopamine In in vitro assays levodopa demonstrates cholinergic receptor antagonism with reported IC50 values typically ranging 10 30 M depending on specific cellular and experimental conditions Based on these pharmacological properties levodopa holds research potential in studies of dopaminergic signaling neuronal plasticity motor function modulation preclinical Parkinson s disease models and stroke recovery investigations
Apexbio Technology LLC MPEP 96206-92-7 10mg
MPEP (CAS 96206-92-7) is a highly selective and systemically active antagonist of the metabotropic glutamate receptor subtype 5 (mGlu5) It demonstrates potent inhibitory activity with an IC50 of 36 nM for mGlu5-mediated phosphoinositide (PI) hydrolysis in human mGlu1b-expressing L (tk-) cells and exhibits no detectable effect on mGlu1b or on group II and III mGlu receptor subtypes at concentrations up to 100 M MPEP also effectively inhibits DHPG-induced PI hydrolysis in hippocampal striatal and cortical slices (IC50 values of 8 nM 20 5 nM and 17 9 nM respectively) It is widely utilized as a pharmacological tool to investigate mGlu5 function and has demonstrated anxiolytic and antidepressant-like effects in animal behavioral models
Apexbio Technology LLC MPEP 96206-92-7 50mg
MPEP (CAS 96206-92-7) is a highly selective and systemically active antagonist of the metabotropic glutamate receptor subtype 5 (mGlu5) It demonstrates potent inhibitory activity with an IC50 of 36 nM for mGlu5-mediated phosphoinositide (PI) hydrolysis in human mGlu1b-expressing L (tk-) cells and exhibits no detectable effect on mGlu1b or on group II and III mGlu receptor subtypes at concentrations up to 100 M MPEP also effectively inhibits DHPG-induced PI hydrolysis in hippocampal striatal and cortical slices (IC50 values of 8 nM 20 5 nM and 17 9 nM respectively) It is widely utilized as a pharmacological tool to investigate mGlu5 function and has demonstrated anxiolytic and antidepressant-like effects in animal behavioral models
Apexbio Technology LLC Trimethobenzamide hydrochloride 554-92-7 200mg
Trimethobenzamide hydrochloride is a dopamine D2 receptor antagonist frequently utilized in biomedical research investigating mechanisms underlying emesis and anti-emetic responses The compound exerts pharmacological effects by inhibiting dopamine receptor-mediated neurotransmission within the chemoreceptor trigger zone (CTZ) of the central nervous system a key regulatory area implicated in nausea and vomiting reflexes Through selective receptor blockade trimethobenzamide hydrochloride allows researchers to elucidate dopamine-dependent molecular and physiological pathways contributing to vomiting in experimental animal models This compound is commonly applied in laboratory settings to characterize the pharmacodynamic profiles of novel anti-emetic agents and to evaluate dopamine receptor-involved emetic signaling The reported IC50 value for dopamine D2 receptor inhibition is approximately 320 nM
Medchemexpress LLC Cloprostenol | 40665-92-7 | 99.9% | 10 MG
Cloprostenol is a synthetic prostaglandin F2α (PGF2α) analogue used as a luteolytic agent in research. It acts as a prostaglandin receptor agonist and is used to induce luteolysis and to study reproductive conditions such as open-cervix pyometra. CAS number 40665-92-7; molecular weight 424.92; molecular formula C22H29ClO6.
- prostaglandin receptor agonist
- induces luteolysis in animal models
- suitable for reproductive and veterinary research
- high purity suitable for analytical and in vitro studies
- stable when stored per manufacturer recommendations
Medchemexpress LLC Ecopladib | 381683-92-7 | 748.11 | 1 MG
Ecopladib is a sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α), with IC50s of 0.15 μM in GLU micelle and 0.11 μM in rat whole blood assays. It inhibits cPLA2α in PAPE liposome assay at 73% at 37 nM and is inactive against COX-1 and COX-2. It also inhibits the production of prostaglandins and leukotrienes. In vivo, Ecopladib is orally efficacious for inhibiting COX-2 derived PGE2 formation and reducing carrageenan-induced paw swelling.
- Sub-micromolar inhibitor of cytosolic phospholipase A2α (cPLA2α)
- Inhibits cPLA2α in GLU micelle and rat whole blood assays
- Inactive against COX-1 and COX-2
- Inhibits production of prostaglandins and leukotrienes
- Orally efficacious for inhibiting COX-2 derived PGE2 formation
- Orally efficacious for reducing carrageenan-induced paw swelling
Medchemexpress LLC Rosavin | 84954-92-7 | 428.43 | 1 ML
Rosavin, an orally bioactive phenylpropanoid from Rhodiola rosea L. (RRL), is an adaptogen that enhances the body's response to environmental stress. It significantly influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation. Rosavin also demonstrates antidepressant, adaptogenic, and anxiolytic effects in mouse models. Additionally, it improves survival by reducing intestinal damage in irradiated rats and protects against Ischemia-reperfusion (I/R)-induced cerebral injury in vivo.
- Enhances the body's response to environmental stress.
- Influences bone tissue metabolism by inhibiting osteoclastogenesis and promoting osteoblast differentiation.
- Demonstrates antidepressant, adaptogenic, and anxiolytic effects.
- Improves survival, reducing intestinal damage in irradiated rats.
- Protects against Ischemia-reperfusion (I/R)-induced cerebral injury in vivo.
Apexbio Technology LLC Trimethobenzamide hydrochloride 554-92-7 500mg
Trimethobenzamide hydrochloride is a dopamine D2 receptor antagonist frequently utilized in biomedical research investigating mechanisms underlying emesis and anti-emetic responses The compound exerts pharmacological effects by inhibiting dopamine receptor-mediated neurotransmission within the chemoreceptor trigger zone (CTZ) of the central nervous system a key regulatory area implicated in nausea and vomiting reflexes Through selective receptor blockade trimethobenzamide hydrochloride allows researchers to elucidate dopamine-dependent molecular and physiological pathways contributing to vomiting in experimental animal models This compound is commonly applied in laboratory settings to characterize the pharmacodynamic profiles of novel anti-emetic agents and to evaluate dopamine receptor-involved emetic signaling The reported IC50 value for dopamine D2 receptor inhibition is approximately 320 nM
Medchemexpress LLC Cloprostenol | 40665-92-7 | 99.9% | 5 MG
Cloprostenol is a prostaglandin F2α (PGF2α) analogue used in research as a luteolytic agent and for studies such as open-cervix pyometra.
- acts as a prostaglandin F2α analogue and induces luteolysis.
- white to off-white solid appearance suitable for analytical use.
- characterized by HPLC, 1H NMR, and MS to confirm identity and purity.
- long-term storage stable at room temperature for the solid form; solvent storage conditions vary.