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Metformin Hydrochloride is is one of the biguanides It suppresses glyconeogenesis in the liver facilitates peripheral use of glucose and inhibits glucose absorption from the intestinal tract via activation of AMPK AMP-activated protein kinase resulting in hypoglycemic effects It has been widely used as a drug to treat type 2 diabetes mellitus in clinical practices as showing hypoglycemic effects independent of insulin secretion in the pancreatic b-cell
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