Phenylpropanoids and polyketides
Medchemexpress LLC BIIE-0246 | 246146-55-4 | 99.1% | 896.05 g/mol | C49H57N11O6 | 10 MG
BIIE-0246 is a non-peptide neuropeptide Y (NPY) Y2 receptor antagonist supplied for laboratory research use. The compound is provided as a high-purity research chemical (CAS 246146-55-4) for in vitro and in vivo pharmacological studies of NPY signaling and receptor pharmacology.
- Potent and selective NPY Y2 receptor antagonist suitable for receptor pharmacology studies.
- High purity (99.10%) appropriate for biochemical and cellular assays.
- Molecular weight 896.05 g/mol, convenient for mass-based preparations.
- Available in small research pack sizes to support pilot and exploratory studies.
- Intended for research use only; not for human or clinical applications.
Medchemexpress LLC Biie-0246 (AR-H 053591) | 246146-55-4 | 99.1% | 896.05 | C49H57N11O6 | 25 MG
BIIE-0246 is a selective, non-peptide antagonist of the neuropeptide Y Y2 receptor used in pharmacological research. It exhibits potent activity (IC50 ≈ 15 nM) and modulates NPY-mediated signaling pathways, including effects on p-AKT S473 and p44/42 MAPK; it has been used in disease models such as ADR nephropathy.
- High potency at NPY Y2 receptor (IC50 ≈ 15 nM).
- High purity suitable for research applications (99.1%).
- Available as solid and as DMSO solution for flexible dosing.
- Molecular formula C49H57N11O6 and molecular weight 896.05.
- Applicable for in vitro and in vivo studies of NPY signaling and renal pathology.
Apexbio Technology LLC BIIE 0246 246146-55-4 10mg
BIIE 0246 (CAS 246146-55-4) is a potent and selective antagonist of the neuropeptide Y Y2 receptor (Y2R) a G protein-coupled receptor involved in presynaptic inhibition within the central and peripheral nervous systems BIIE 0246 exhibits high affinity for Y2R with an IC50 of 3 3 nM in radioligand binding assays and Ki values between 8 15 nM in HEK293 cells expressing rat Y2 receptors In hippocampal slices BIIE 0246 (100 nM) reverses NPY-induced inhibition of excitatory postsynaptic potentials In vivo administration in rats attenuates PYY(3-36)-mediated suppression of food intake and increases feeding in satiated animals supporting its use in research on appetite regulation and anxiety-related behavior
Chem-Impex International, Inc. D-b-Phenyllactic acid | 7326-19-4 | MFCD00078062 | 25G
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Chem-Impex International, Inc. 1,3-Diphenyl-1,3-propanedione | 120-46-7 | MFCD00003085 | 25G
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This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.for further information and support please go to the website of the issuing Pharmacopoeia.
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