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Phenylpropaniods are organic compounds characterized by having an aromatic ring and a three-carbon propene tail. Polyketides are compounds characterized by having two or more carbonyl functional groups connected with a single carbon atom.
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BLU 451 is a central nervous system (CNS)-penetrant wild-type EGFR-sparing covalent inhibitor of epidermal growth factor receptor (EGFR) exon 20 insertion (Ex20ins) with an IC50 of 7-78 nM It also exhibits a potent anti-tumor efficacy
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Chemical. CAS 27425-55-4. Formula C20H19N3O2. Molecular Weight 333.38. Coumarin 7 is a greenish yellow fluorescent dye. It has good heat resistance and light resistance, good migration resistance and high tinting strength with wide application. Coumarin 7 is a laser dye that is used as green phosphorescent dopant material for organic light-emitting diodes OLED. Its derivatives are used in medicine and chemistry. Spectral Data lambdaabs 438nm, lambdaem 266nm/355nm, lambdaex 490nm, lambdalaser 520nm.
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Cinnamyl Alcohol is an active component from chestnut flower inhibits increased PPAR expression exhibits anti-obesity antioxidant and anti-inflammatory activities[1]
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Chemical. CAS 55804-66-5. Formula C18H19NO4. Molecular Weight 313.35. Coumarin 314 is a rigidized aminocoumarin derivative used as a laser dye with an absorption maximum of 436nm. It can be used as starting material for the synthesis of fluorescent probes. Spectral data lambdamax 436nm in ethanol, epsilon extinction coefficient >39000 at 389-401 nm in ethanol, lambdalaser 504nm.
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An isoflavone glycoside with diverse biological activities; inhibits oleic acid-induced lipid accumulation in HepG2 cells and stimulates glucose uptake in C2C12 mouse skeletal muscle myoblasts at 10 µM; inhibits compound 48/80- or histamine-induced scratching behavior in mice at 2 mg/kg; reduces serum levels of IgE in a mouse model of atopic dermatitis; increases serum levels of osteocalcin and ALP and restores mechanical bone hardness in an ovariectomized rat model of osteoporosis; decreases hepatic cholesterol and triglyceride levels, serum LDL and apolipoprotein B levels, and hepatic injury in a mouse model of fructose-induced liver injury at 80 and 160 mg/kg
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A stable isomer of 15(S)-HETE that elicits contraction of isolated pulmonary arteries from rabbits and inhibits the proliferation and migration of PC-3 cells
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Palomid 529 is a small-molecule research inhibitor that targets both mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), modulating the PI3K/Akt/mTOR signaling pathway. It has been used in preclinical studies and early clinical research to reduce tumor growth, angiogenesis, and vascular permeability, and has been investigated for neovascular age-related macular degeneration.
Dual inhibition of mTORC1 and mTORC2.
Documented in peer-reviewed literature and public chemical databases.
High reported purity suitable for analytical use.
Suitable as an analytical standard and research reagent.
Provided with batch-specific certificate of analysis data.
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MRL-494 hydrochloride is an antibacterial agent and an inhibitor of β-barrel assembly machine A (BamA). It is impervious to efflux and the outer membrane permeability barrier, making it effective against both Gram-positive and Gram-negative bacteria. This agent lethally disrupts the cytoplasmic membrane and inhibits outer membrane protein biogenesis by targeting BamA.
Inhibits β-barrel assembly machine A (BamA)
Effective against Gram-positive bacteria
Effective against Gram-negative bacteria
Disrupts cytoplasmic membrane
Inhibits outer membrane protein biogenesis
White to off-white solid
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