GW2580-d6 is a deuterium-labeled version of GW2580, an orally bioavailable and selective inhibitor of c-Fms kinase. It completely inhibits human cFMS kinase in vitro at a concentration of 0.06 μM. This compound acts as a competitive inhibitor of ATP binding to the cFMS kinase, thereby inhibiting colony-stimulating-factor-1 signaling. Intended for research use only, it appears as a white to off-white solid.
- Stable isotope: Contains deuterium labeling, useful as a tracer and internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- High purity: 98.36% purity ensures reliable experimental results.
- Selective inhibition: Potently inhibits c-Fms kinase, impacting colony-stimulating-factor-1 signaling.
- Orally bioavailable: The unlabeled compound, GW2580, is orally bioavailable.